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EMBO Rep. 2011 Apr;12(4):321-6. doi: 10.1038/embor.2011.7. Epub 2011 Feb 25.
CO2 exacerbates oxygen toxicity.
Ezraty B1, Chabalier M, Ducret A, Maisonneuve E, Dukan S.
Author information
Abstract
Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO(2) (concentration range studied: 40-1,000 p.p.m.) increases death rates due to H(2)O(2) stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H(2)O(2)-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions (Hpx(-) dps and recA fur), presumably because of their inability to tolerate ROS, seems to depend on CO(2) concentration. Thus, CO(2) exacerbates ROS toxicity by increasing oxidative cellular lesions.
CO2 exacerbates oxygen toxicity. - PubMed - NCBI
EMBO Rep. 2011 Apr;12(4):321-6. doi: 10.1038/embor.2011.7. Epub 2011 Feb 25.
CO2 exacerbates oxygen toxicity.
Ezraty B1, Chabalier M, Ducret A, Maisonneuve E, Dukan S.
Author information
Abstract
Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO(2) (concentration range studied: 40-1,000 p.p.m.) increases death rates due to H(2)O(2) stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H(2)O(2)-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions (Hpx(-) dps and recA fur), presumably because of their inability to tolerate ROS, seems to depend on CO(2) concentration. Thus, CO(2) exacerbates ROS toxicity by increasing oxidative cellular lesions.
CO2 exacerbates oxygen toxicity. - PubMed - NCBI