Aspirin As A Suppressor Of Cancer-related Epigenetic Aging

Kvothe

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Great find, thanks. There is already good evidence showing that aspirin prevents excess methylation, probably via the acetylation of histones. Seeing such a striking difference in this study is really remarkable. Meanwhile, they treat colon cancer patients with highly expensive, toxic chemo mixtures when the most effective drug is available OTC for a few cents.

The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice

"In conclusion, we used an AOM/DSS-induced CAC model to demonstrate the preventive effect of the chronic use of low-dose ASA, suggesting that the in vivo mechanism of ASA appear to involve epigenetic modifications. Specifically, ASA at the dose of 0.02% inhibited the protein expression and activity of HDACs (histone deacetylase), as well as restoring the global H3K27ac level."​
 
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