Antioxidant Effect Of Lidocaine And Procaine On Reactive Oxygen Species-induced Endothelial Dysfunct

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  1. paymanz

    paymanz Member

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    Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta

    Korean J Anesthesiol. 2010 Aug; 59(2): 104–110.
    Published online 2010 Aug 20. doi: 10.4097/kjae.2010.59.2.104
    PMCID: PMC2926425
    Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta
    Jae Myeong Lee,2 Jung Kook Suh,[​IMG]1 Ji Seon Jeong,1 Sang Yun Cho,1 and Dong Won Kim1
    Author information ► Article notes ► Copyright and License information ►
    This article has been cited by other articles in PMC.

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    Abstract
    Background
    Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in the endothelium. We tested the antioxidant effect of lidocaine and procaine on ROS-induced endothelial damage in the rabbit aorta.

    Methods
    Aortic rings isolated from rabbits were suspended in an organ bath filled with Krebs-Henseleit (K-H) solution bubbled with 5% CO2 and 95% O2 at 37.5℃. After precontraction with phenylephrine (PE, 10-6 M), changes in tension were recorded following a cumulative administration of acetylcholine (ACh 3 × 10-8 to 10-6 M). Differences were measured as percentages of ACh-induced relaxation of aortic rings before and after exposure to ROS as generated by electrolysis of the K-H solution. The aortic rings were pretreated with lidocaine or procaine (10-5 M to 3 × 10-3 M) to compare their effects, as well as ROS scavengers, catalase, mannitol, sodium salicylate, and deferoxamine, and a catalase inhibitor, 3-amino-1,2,4-triazole (3AT).

    Results
    Lidocaine and procaine dose-dependently maintained endothelium-dependent relaxation induced by ACh despite ROS activity (P < 0.05 vs control value). The 3AT pretreated procaine (3 × 10-3 M) group decreased more significantly than the un-pretreated procaine group (P < 0.05).

    Conclusions
    These findings suggest that lidocaine and procaine dose-dependently preserve endothelium-dependent vasorelaxation against ROS attack, potentially via hydrogen peroxide scavenging.
     
  2. aarfai

    aarfai Member

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    I use lidocaine 5% cream 1-2x week and it warms me up nicely. I asked ray about this and he replied 'absorption through the skin from the 5% can have good regional and systemic effects'
     
  3. danishispsychic

    danishispsychic Member

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    I had a session of prolotherapy with that junk and it made me so depressed. hated it .
     
  4. OP
    paymanz

    paymanz Member

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    Interesting, its around one week i take 100-400 mg lido a day(divided small dosages every few hours,orally) and it improved my energy ,especially im become more physically active when i take it, and also my sleep is improved i think.

    There is also one study using it for chronic fatigue syndrome with good results.

    But everyone must be careful,higher doses are dangerous.

    For me it was opposite, it made my mood better, but maybe it to soon to judge it, what was the dosage you used?it was injectio right?
     
  5. syncronicity

    syncronicity Member

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    Couple Qs: do you make the 5% solution or purchase?
    Where do you source (purchase), and/or ingredeients for homemade?
    Where do you apply it and how much per application?

    Any additional observations on effect?
     
  6. ecstatichamster

    ecstatichamster Member

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    Lidocaineforless.com
     
  7. aarfai

    aarfai Member

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    lidocaineforless.com I've dosed 50mg maybe 5x in the past year
     
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