5α-reductase 2 Deficiency Leads To Reduced Dominance-related And Impulse-control Behaviors

[Lokzo]

Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors - ScienceDirect


Highlights
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5α-reductase 2 (5αR2) catalyzes the conversion of testosterone into DHT.

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We found that 5αR2 knockout (KO) mice have reduced dominance-related behaviors.

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These deficits are accompanied by lower novelty-seeking and risk-taking.

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5αR2 KO mice exhibit reduced D2-like receptor binding in the nucleus accumbens.

 

[postman]

I think it's a mistake to conflate low inhibition with low impulse control, I think those are two separate things.

 

[Mauritio]

Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors - ScienceDirect


Highlights
•
5α-reductase 2 (5αR2) catalyzes the conversion of testosterone into DHT.

•
We found that 5αR2 knockout (KO) mice have reduced dominance-related behaviors.

•
These deficits are accompanied by lower novelty-seeking and risk-taking.

•
5αR2 KO mice exhibit reduced D2-like receptor binding in the nucleus accumbens.

Interesting study. Cistanche increases 5a reductase2, 12 fold ! But inhibites 5a reductase1 a little .
So cistanche has pro dominance effect. And the D2 agonism is good for insulin sensitivity and prolactin lowering .

Do you have any knowledge on effects of 5aR1 vs. 5aR2 ?