tlr4

  1. haidut

    Blocking the endotoxin receptor (TLR4) may prevent / treat hearing loss

    I did a post a few months ago on the connection between tinnitus and serotonin - i.e. using anti-serotonin drugs may treat tinnitus. Since tinnitus is almost always a precursor state to hearing loss (and eventually deafness), the two conditions obviously go hand-in-hand and are likely caused by...
  2. haidut

    Endotoxin (LPS) may be the cause of fatal lung damage in COVID-19

    Yet another study, which demonstrates that there is virtually no disease (acute of chronic, infections or not) where the infamous LPS does not play a causative role. As it turns out, the often fatal inflammatory reaction (cytokine storm) that usually kills patients with COVID-19 in ICU, is...
  3. haidut

    Silica, present in most supplements/food, activates the endotoxin receptor (TLR4)

    Many of my readers know about the health risks of silica - a substance doctors and pundits call completely "benign, present in virtually all commercially sold dietary supplements and also in most commercially sold food (even organic ones!). The most commonly used form commercially is silicon...
  4. haidut

    Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

    Yet another study implicating the great villain of systemic health - endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of...
  5. haidut

    Activation Of The Endotoxin Receptor (TLR4) May Cause Hearing Loss

    There is currently an epidemic of tinnitus (ear ringing) and hearing loss in virtually all developed countries. Experts are scratching heads and are failing to come up with a reason/explanation for this epidemic. As it often happens, the cause is often hidden in plain sight and if one follows...
  6. haidut

    Pregnenolone Safe And Effective In Big Human Trial For Back Pain

    About 2 years ago I posted about a study that suggested pregnenolone may relieve low-back pain in humans. Pregnenolone Relieves Chronic Low Back Pain (human Study) At the time, a bigger human clinical trial was planned and the results of that trial were just released. Pregnenolone, slowly...
  7. haidut

    Asthma Is Driven By Endotoxin And Its Receptors (TLR4, TLR5)

    Yet another study demonstrating the crucial role of the endotoxin/LPS (and its sentinel receptors) in a chronic idiopathic condition - in this case asthma. The cause of asthma is, as usual, officially claimed to be unknown but it is known that asthma can be exacerbated by environmental pollution...
  8. haidut

    Epilepsy, As A Result Of Brain Injury (TBI), Is Caused By Endotoxin Receptor (TLR4)

    Traumatic brain injury (TBI) is a pathology affecting most often military staff exposed to explosions, competitive athletes in contact sports (especially in the NFL), accident victims, etc but lately has also been shown to occur in more benign situations such as repeated low-grade impacts such...
  9. Mauritio

    Serotonin Causes Obesity, Diabetes, Fibrosis,liver Damage ,increases Endotoxin And NO

    Inspired by this thread Serotonin/endotoxin/PUFA As Primary Causes Of Depression And Diabetes; Can Be Easily Blocked I was reading a few more recent studies on the detrimental effect of serotonin on ones health. It seems clear that by now it is known in medicine, that blocking it is highly...
  10. haidut

    Emulsifiers Found In Most Commercial Foods Cause Brain Tumors, Hemorrhage, And Stroke

    A really interesting study that demonstrates how emulsifiers considered "benign" by the FDA/USDA and present in virtually all commercial food can actually cause quite a bit of damage to health. The study demonstrates that even a low-dose of a common commercial emulsifier Polysorbate 80 (P80)...
  11. haidut

    Endotoxin Has A G.E.L.D.I.N.G Effect, Causes Obesity And Hypogonadism

    A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable...
  12. haidut

    Supplementation With (long Chain) Saturated Fats Protects Liver From Alcohol

    As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver...
  13. haidut

    Allopregnanolone As A Treatment Of Alzheimer Disease (AD)

    It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...
  14. haidut

    Chronic Nerve Pain May Be Caused By Endotoxin, Commercial Food, And Pharma Drugs

    I posted a few threads last year demonstrating that some cases of chronic nerve pain may be caused by a side effects of opioids - activation of TLR4. However, that study only looked at why certain patients using opioids for severe pain go on to develop chronic pain of phantom origin. As such...
  15. haidut

    Inhibiting Fatty Acid Synthesis (FAS) Dramatically Improves Sepsis Survival Rate

    Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...
  16. haidut

    Progesterone May Bind And Deactivate Endotoxin (LPS) Directly

    I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation...
  17. haidut

    MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

    Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS - i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology...
  18. haidut

    Endotoxin (LPS) Linked To Lower Survival In Cancer

    Another study about endotoxin, this time linking higher sensitivity to endotoxin to lower survival chance for people with lymphoma. While the study below looked at only one cancer, there are multiple studies with other cancer that have found similar link. Endotoxin and cancer go hand in hand...
  19. haidut

    Blocking Endotoxin (LPS) May Reverse/cure Diabetes Type I

    Yet another study demonstrating the key role of endotoxin in the pathology of perhaps the most widespread chronic disease - diabetes. The study below discovered that the proliferation of the insulin-producing beta-cells in the pancreas is controlled almost entirely by the TLR4/TLR2 receptor...
  20. haidut

    Endotoxin (LPS) May Cause Depression / Anhedonia

    As many readers know, anhedonia is one of the most pernicious aspects of clinical depression. It is present in other mental health conditions but is most pronounced and severe in clinical unipolar depression. It is also especially resistant to treatment and many doctors simply accept it as...
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