tlr4

  1. NewACC

    Serotonin antagonists fail to prevent endotoxin lethality in healthy mice

    https://www.karger.com/Article/Abstract/162500 Very scary article. I'd be glad if @haidut and @Hans commented it
  2. haidut

    Endotoxin (LPS) - a reliable biomarker of cardiovascular disease (CVD)

    It looks like more and more medical groups are waking up to the important role LPS plays in many chronic diseases. In the body, LPS is transported back to the liver for processing/excretion by the so-called lipopolysaccharide binding protein (LBP) and by measuring serum levels of LBP, one can...
  3. haidut

    Endotoxin (LPS) may drive kidney damage in diabetes type II

    Not much of a news, but I like adding to the, already big, pile of evidence that endotoxin/LPS is a major causal factor in virtually all chronic conditions that continue to mystify medicine. Since the study below mentions the compromised intestinal barrier in diabetes patients, interventions...
  4. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
  5. haidut

    Endotoxin (LPS) causes Alzheimer Disease (AD)

    I have made posts on this topic in the past, but it seems this most recent study directly states that endotoxin/LPS is a major cause of AD. All other studies have been either animal models or did not directly implicate LPS. The study below claims to be the first that integrates all available...
  6. haidut

    Blocking endotoxin may reverse cognitive decline of aging

    Another study implicating endotoxin (LPS) and its associated receptor (TLR4) in a phenotype of aging considered "normal" by mainstream medicine, though it almost universally progresses into dementia territory with advancing age, to the point where 90%+ of people over 85 have at least moderate...
  7. haidut

    Endotoxin (LPS) drives obesity, diabetes and CVD in young people

    It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming that LPS is not an issue at all for any human with a functioning liver, a number of high profile studies have come out recently demonstrating chronic endotoxemia (even low-grade) is a causal...
  8. Mauritio

    SARS-cov-2 spike protein activates endotoxin receptor TLR4

    Many people die of sepsis when they get covid . This study shows that the SARS-cov-2 spike protein activates the endotoxin receptor TLR4. Interestingly this was completely unrelated to its abilty to bind to ACE2 . So the spike protein induces inflammation in at least two ways: inhibition of...
  9. Kvothe

    Anti-Peat Compared to soybean oil and olive oil coconut oil results in endotoxemia and fatty liver

    Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil Author links open overlay panelValeriaLópez-Salazarab1 Mónica...
  10. haidut

    Endotoxin (LPS) may directly cause cancerization of normal cells

    A very interesting new study, which confirms the direct causal role LPS has in chronic inflammatory diseases, and especially in cancer. In addition, the study may answer one of the long-standing critiques the medical establishment has always had against the hypothesis that LPS causes cancer (and...
  11. haidut

    Endotoxin (LPS) causes rheumatoid arthritis...and COVID-19

    A great new study, which is perhaps the first to directly point the finger at endotoxin as perhaps the main cause of rheumatoid arthritis (RA). RA is an "autoimmune" condition and not only shares symptoms with other similar conditions such as Lupus, psoriasis, MS, etc, but now all of them are...
  12. haidut

    Endotoxin (LPS) as a cause of liver disease, obesity and diabetes

    The first article below is actually about praising fermented foods, which I don't really agree with. So, I am posting it mostly because of the quote on endotoxin/LPS, which is a very rare finding in published medical literature since medicine does not recognize chronic, low-grade endotoxemia as...
  13. haidut

    Blocking the endotoxin receptor (TLR4) may prevent / treat hearing loss

    I did a post a few months ago on the connection between tinnitus and serotonin - i.e. using anti-serotonin drugs may treat tinnitus. Since tinnitus is almost always a precursor state to hearing loss (and eventually deafness), the two conditions obviously go hand-in-hand and are likely caused by...
  14. haidut

    Endotoxin (LPS) may be the cause of fatal lung damage in COVID-19

    Yet another study, which demonstrates that there is virtually no disease (acute of chronic, infections or not) where the infamous LPS does not play a causative role. As it turns out, the often fatal inflammatory reaction (cytokine storm) that usually kills patients with COVID-19 in ICU, is...
  15. haidut

    Silica, present in most supplements/food, activates the endotoxin receptor (TLR4)

    Many of my readers know about the health risks of silica - a substance doctors and pundits call completely "benign, present in virtually all commercially sold dietary supplements and also in most commercially sold food (even organic ones!). The most commonly used form commercially is silicon...
  16. haidut

    Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

    Yet another study implicating the great villain of systemic health - endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of...
  17. haidut

    Activation Of The Endotoxin Receptor (TLR4) May Cause Hearing Loss

    There is currently an epidemic of tinnitus (ear ringing) and hearing loss in virtually all developed countries. Experts are scratching heads and are failing to come up with a reason/explanation for this epidemic. As it often happens, the cause is often hidden in plain sight and if one follows...
  18. haidut

    Pregnenolone Safe And Effective In Big Human Trial For Back Pain

    About 2 years ago I posted about a study that suggested pregnenolone may relieve low-back pain in humans. Pregnenolone Relieves Chronic Low Back Pain (human Study) At the time, a bigger human clinical trial was planned and the results of that trial were just released. Pregnenolone, slowly...
  19. haidut

    Asthma Is Driven By Endotoxin And Its Receptors (TLR4, TLR5)

    Yet another study demonstrating the crucial role of the endotoxin/LPS (and its sentinel receptors) in a chronic idiopathic condition - in this case asthma. The cause of asthma is, as usual, officially claimed to be unknown but it is known that asthma can be exacerbated by environmental pollution...
  20. haidut

    Epilepsy, As A Result Of Brain Injury (TBI), Is Caused By Endotoxin Receptor (TLR4)

    Traumatic brain injury (TBI) is a pathology affecting most often military staff exposed to explosions, competitive athletes in contact sports (especially in the NFL), accident victims, etc but lately has also been shown to occur in more benign situations such as repeated low-grade impacts such...
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