tlr4

  1. haidut

    Parkinson Disease (PD) akin to infectious disease - driven by endotoxin, damaged mitochondria

    Yet another study demonstrating that there is no need for genes or any other hereditary mechanism to explain the cause and development of PD. The study below demonstrated that the presence of damaged mitochondrial DNA in the bloodstream is sufficient to cause all symptoms of PD, and the effects...
    • haidut
    • Thread
    • endotoxin lps mitochondria mtdna parkinson prion tlr4 tlr9
    • Replies: 3
    • Forum: Scientific Studies
  2. haidut

    Blocking endotoxin (TLR4) may prevent death from viral infections (COVID-19/ARDS)

    Almost a decade ago I posted about a "rogue" study which had the audacity to suggest that most of so-called viral infections (including HIV) produce most of their most severe symptoms not through the virus or its direct effects, but through synergism with the bacterial endotoxin (LPS) that we...
    • haidut
    • Thread
    • ards covid-19 endotoxin flu inflammation influenza lps tlr4
    • Replies: 6
    • Forum: Scientific Studies
  3. haidut

    Serum endotoxin level is a reliable biomarker of liver disease

    It looks like the interest in gut-derived pathogenic substances is steadily increasing in the medical field. After claiming for decades (and still doing so) that liver disease is either genetic in origin or driven mostly by sugar (especially fructose) consumption, now studies like the one below...
    • haidut
    • Thread
    • endotoxin fibrosis inflammation liver lps nafld nash tlr4
    • Replies: 16
    • Forum: Scientific Studies
  4. NewACC

    Serotonin antagonists fail to prevent endotoxin lethality in healthy mice

    https://www.karger.com/Article/Abstract/162500 Very scary article. I'd be glad if @haidut and @Hans commented it
  5. haidut

    Endotoxin (LPS) - a reliable biomarker of cardiovascular disease (CVD)

    It looks like more and more medical groups are waking up to the important role LPS plays in many chronic diseases. In the body, LPS is transported back to the liver for processing/excretion by the so-called lipopolysaccharide binding protein (LBP) and by measuring serum levels of LBP, one can...
  6. haidut

    Endotoxin (LPS) may drive kidney damage in diabetes type II

    Not much of a news, but I like adding to the, already big, pile of evidence that endotoxin/LPS is a major causal factor in virtually all chronic conditions that continue to mystify medicine. Since the study below mentions the compromised intestinal barrier in diabetes patients, interventions...
    • haidut
    • Thread
    • ckd diabetes endotoxin gut barrier kidney damage lps microalbumineria tlr4
    • Replies: 3
    • Forum: Scientific Studies
  7. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
    • haidut
    • Thread
    • cortisol endotoxin glucocorticoid inflammation insulin lps tlr tlr4
    • Replies: 4
    • Forum: Scientific Studies
  8. haidut

    Endotoxin (LPS) causes Alzheimer Disease (AD)

    I have made posts on this topic in the past, but it seems this most recent study directly states that endotoxin/LPS is a major cause of AD. All other studies have been either animal models or did not directly implicate LPS. The study below claims to be the first that integrates all available...
    • haidut
    • Thread
    • alzheimer dementia endotoxin fiber inflammation lps tlr4
    • Replies: 6
    • Forum: Scientific Studies
  9. haidut

    Blocking endotoxin may reverse cognitive decline of aging

    Another study implicating endotoxin (LPS) and its associated receptor (TLR4) in a phenotype of aging considered "normal" by mainstream medicine, though it almost universally progresses into dementia territory with advancing age, to the point where 90%+ of people over 85 have at least moderate...
    • haidut
    • Thread
    • brain cognitive dementia endotoxin inflammation lps memory tlr4
    • Replies: 5
    • Forum: Scientific Studies
  10. haidut

    Endotoxin (LPS) drives obesity, diabetes and CVD in young people

    It looks like medicine is starting to change course on its attitude to endotoxin (LPS). After claiming that LPS is not an issue at all for any human with a functioning liver, a number of high profile studies have come out recently demonstrating chronic endotoxemia (even low-grade) is a causal...
  11. Mauritio

    SARS-cov-2 spike protein activates endotoxin receptor TLR4

    Many people die of sepsis when they get covid . This study shows that the SARS-cov-2 spike protein activates the endotoxin receptor TLR4. Interestingly this was completely unrelated to its abilty to bind to ACE2 . So the spike protein induces inflammation in at least two ways: inhibition of...
  12. Kvothe

    Compared to soybean oil and olive oil coconut oil results in endotoxemia and fatty liver

    Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil Author links open overlay panelValeriaLópez-Salazarab1 Mónica...
    • Kvothe
    • Thread
    • coconut oil endotoxin soybean oil tlr4
    • Replies: 23
    • Forum: Debate
  13. haidut

    Endotoxin (LPS) may directly cause cancerization of normal cells

    A very interesting new study, which confirms the direct causal role LPS has in chronic inflammatory diseases, and especially in cancer. In addition, the study may answer one of the long-standing critiques the medical establishment has always had against the hypothesis that LPS causes cancer (and...
    • haidut
    • Thread
    • cancer cancerization chronic endotoxin inflammation low-grade lps tlr4
    • Replies: 2
    • Forum: Scientific Studies
  14. haidut

    Endotoxin (LPS) causes rheumatoid arthritis...and COVID-19

    A great new study, which is perhaps the first to directly point the finger at endotoxin as perhaps the main cause of rheumatoid arthritis (RA). RA is an "autoimmune" condition and not only shares symptoms with other similar conditions such as Lupus, psoriasis, MS, etc, but now all of them are...
    • haidut
    • Thread
    • autoimmune covid-19 endotoxin lps microbiome rheumatoid arthritis tlr4
    • Replies: 14
    • Forum: Scientific Studies
  15. haidut

    Endotoxin (LPS) as a cause of liver disease, obesity and diabetes

    The first article below is actually about praising fermented foods, which I don't really agree with. So, I am posting it mostly because of the quote on endotoxin/LPS, which is a very rare finding in published medical literature since medicine does not recognize chronic, low-grade endotoxemia as...
    • haidut
    • Thread
    • diabetes endotoxin hdl hepatitis liver disease lps obesity tlr4
    • Replies: 17
    • Forum: Scientific Studies
  16. haidut

    Blocking the endotoxin receptor (TLR4) may prevent / treat hearing loss

    I did a post a few months ago on the connection between tinnitus and serotonin - i.e. using anti-serotonin drugs may treat tinnitus. Since tinnitus is almost always a precursor state to hearing loss (and eventually deafness), the two conditions obviously go hand-in-hand and are likely caused by...
    • haidut
    • Thread
    • 5-ht deafness endotoxin hearing loss inflammation lps tinnitus tlr4
    • Replies: 8
    • Forum: Scientific Studies
  17. haidut

    Endotoxin (LPS) may be the cause of fatal lung damage in COVID-19

    Yet another study, which demonstrates that there is virtually no disease (acute of chronic, infections or not) where the infamous LPS does not play a causative role. As it turns out, the often fatal inflammatory reaction (cytokine storm) that usually kills patients with COVID-19 in ICU, is...
    • haidut
    • Thread
    • covid-19 endotoxin iatrogenic inflammation lps lung damage mortality tlr4
    • Replies: 0
    • Forum: Scientific Studies
  18. haidut

    Silica, present in most supplements/food, activates the endotoxin receptor (TLR4)

    Many of my readers know about the health risks of silica - a substance doctors and pundits call completely "benign, present in virtually all commercially sold dietary supplements and also in most commercially sold food (even organic ones!). The most commonly used form commercially is silicon...
    • haidut
    • Thread
    • bones endotoxin inflammation lps lung silica silicon dioxide tlr4
    • Replies: 78
    • Forum: Scientific Studies
  19. haidut

    Endotoxin (LPS) as a cause of systemic inflammation seen in obesity

    Yet another study implicating the great villain of systemic health - endotoxin / LPS. It is well-known that most people with obesity have high levels of inflammatory biomarkers both in their tissues and bloodstream. The study below demonstrates that the inflammation seen in adipose tissue of...
  20. haidut

    Activation Of The Endotoxin Receptor (TLR4) May Cause Hearing Loss

    There is currently an epidemic of tinnitus (ear ringing) and hearing loss in virtually all developed countries. Experts are scratching heads and are failing to come up with a reason/explanation for this epidemic. As it often happens, the cause is often hidden in plain sight and if one follows...
    • haidut
    • Thread
    • endotoxin hearing loss inflammation lps serotonin tinnitus tlr4
    • Replies: 20
    • Forum: Scientific Studies
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