tlr4

  1. haidut

    Aspirin As A Cure For Sepsis

    If the truly wonder-drug properties of aspirin were considered lacking by some medical authorities, now we can add curing sepsis to that list. Sepsis is the leading cause of death in hospitalized patients, regardless of age, condition, treatment, etc. It is largely considered a lost cause once...
    • haidut
    • Thread
    • aspirin caspase inflammation nsaid organ failure sepsis tlr4 treatment
    • Replies: 54
    • Forum: Scientific Studies
  2. haidut

    Bladder Dysfunction And Incontinence Likely Due To Endotoxin (TLR4)

    Ray has mentioned a few times over email to people that bladder irritation or even kidney problems are likely due to increased endotoxin load. My urologists friends laugh so hard when I mention this in our discussions, but lately they seem more gloomy than amused. I suspect that this new study...
    • haidut
    • Thread
    • bladder diabetes dysfunction endotoxin incontinence inflammation tlr4
    • Replies: 6
    • Forum: Scientific Studies
  3. P

    Saturated Fatty Acids,including Lauric Acid Activates TLR4

    Some studies showing coconut oil has anti stress effects,but this one surprised me! Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner The saturated fatty acids...
  4. haidut

    Endotoxin (LPS) Is A Probable Cause For Chronic Fatigue Syndrome (CFS / ME)

    It seems like the bad news about endotoxin (LPS) just don't stop. After the recent studies implicating in many degenerative conditions, and especially Alzheimer, systemic sclerosis, ALS, etc not this study links it to the so-called chronic fatigue syndrome (CFS / ME), which the medical...
    • haidut
    • Thread
    • cfs chronic fatigue syndrome endotoxin lps me myalgic encephalopathy pge2 prostaglandins tlr4
    • Replies: 6
    • Forum: Scientific Studies
  5. haidut

    Endotoxin (LPS) May Be A Causative Factor In Alzheimer Disease (AD)

    I posted recently about a study that found many of the chronic degenerative diseases can be traced back to endotoxin and excess iron. Endotoxin And Iron Finally Recognized As Potential Causes Of Many Diseases This study went a step further and identified endotoxin (LPS) in the brains of AD...
    • haidut
    • Thread
    • alzheimer's bacteria brain endotoxin lps neurodegenerative tlr4
    • Replies: 17
    • Forum: Scientific Studies
  6. haidut

    Low Social Status Damages The Immune System

    I have posted before on the link between status and health and I think user @Such_Saturation also posted a study on reversal of dominant social status leading to serotonergic dominance. This latest study shows that it is the relative difference of social status that matters. So, even though a...
    • haidut
    • Thread
    • chronic stress endotoxin immune system immunity inflammation lps social isolation social status tlr4
    • Replies: 27
    • Forum: Scientific Studies
  7. haidut

    Systemic Sclerosis (scleroderma) May Be Due To Endotoxin; Blocking TLR4 Can Treat It

    In a recent interview Peat explained the connection between endotoxin, hypothyroidism, and rheumatoid arthritis. I recently posted a study claiming that chronic activation of the endotoxin receptor TLR4 synergizes greatly with iron and is probably a causative factor in many degenerative...
    • haidut
    • Thread
    • antagonist endotoxin lps reverse scleroderma systemic sclerosis tlr4 treatment
    • Replies: 5
    • Forum: Scientific Studies
  8. haidut

    Blocking Endotoxin (TLR4) Can Prevent Pre-term Birth

    The number of so-called preemies has been steadily rising over the last 2 decades. The official explanation is that the cause is unknown, but the only officially approved treatment is progesterone. This study sheds a bit more light and claims that endotoxin is behind the majority of cases of...
    • haidut
    • Thread
    • article endotoxin naloxone pre-term labor preemie prevention tlr4
    • Replies: 5
    • Forum: Scientific Studies
  9. haidut

    Glycine Is An Endotoxin (TLR4) Antagonist

    We can now add glycine to the substances that inhibit endotoxin or its effects. The endotoxin antagonism probably explains a good deal of glycine's protective effects on the liver from all sorts of assaults, but especially ethanol/alcohol (which is a known TLR4 agonist). The in-vivo study used a...
    • haidut
    • Thread
    • antagonist endotoxin glycine lipopolysaccharide liver lps study tlr4 tnf
    • Replies: 37
    • Forum: Scientific Studies
  10. haidut

    Vitamin A (retinol) Is Endotoxin (LPS / TLR4) Antagonist

    Another one in the series of endotoxin antagonism featuring so far vitamins D and B2. Vitamin B2 (riboflavin) Is Endotoxin Antagonist Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections Vitamin D Is Endotoxin (LPS / TLR4) Antagonist, May Treat LPS-linked...
    • haidut
    • Thread
    • antagonist endotoxin fibrosis inflammation lps retinol tlr4 vitamin a
    • Replies: 19
    • Forum: Scientific Studies
  11. haidut

    Vitamin B2 (riboflavin) Is Endotoxin (LPS / TLR4) Antagonist

    This is just a follow up on the recent post on both riboflavin and vitamin D. Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections https://raypeatforum.com/community/threads/vitamin-d-is-endotoxin-lps-tlr4-antagonist-may-treat-lps-linked-conditions.12060/...
  12. haidut

    Vitamin D Is Endotoxin (LPS / TLR4) Antagonist, May Treat LPS-linked Conditions

    The activation of TLR by various substances like endotoxin, ethanol / alcohol, opioids, SSRI, etc is involved in the pathogenesis of many conditions, especially IBD, colon cancer, periodontal disease, etc. There are very few effective endotoxin antagonists in clinical use, which is unfortunate...
    • haidut
    • Thread
    • antagonist calcitriol cancer cholecalciferol endotoxin fibrosis inflammation liver disease lps periodontal disease periodontitis tlr4 tnf vitamin d
    • Replies: 27
    • Forum: Scientific Studies
  13. haidut

    Acute Colon / Lung Damage May Be Due To Endotoxin; Breast Milk Stops It

    The study was done to mimic the condition necrotizing enterocolitis in premature babies, but if you look at the actual study the scientists think the mechanism is probably the same for most cases of acute colon and lung damage. Once again, our old "friend" endotoxin rears its ugly head and acts...
    • haidut
    • Thread
    • antagonist breast milk c34 colitis edema endotoxin lung lung damage sugar tlr4
    • Replies: 2
    • Forum: Scientific Studies
  14. haidut

    Opioids Increase Pain Through Endotoxin Receptor, Minocycline Reverses The Effect

    Most people here know Peat's opinion about opioids due to their effects on histamine, estrogen, and promoting tissue growth. A few weeks ago I posted a link in regards to the so-called "endotoxin receptor" known as TLR4, and how opioids are the main class of substances that activate that...
    • haidut
    • Thread
    • endotoxin inflammation minocycline narcotics opioid opioids pain salt sodium tlr4
    • Replies: 18
    • Forum: Scientific Studies
  15. haidut

    Prostate Enlargement (BPH) May Be Due To Endotoxin

    BPH is a very common problem, apparently affecting more than 70%of men over 50. Ray has said in some email exchanges that prostatitis and BPH are linked with endotoxin. I was not able to find much published research on the topic but this new study finally makes that claim. What is more...
    • haidut
    • Thread
    • bmi bph endotoxin inflammation lps prostate prostate enlargement psa study tlr4
    • Replies: 43
    • Forum: Scientific Studies
  16. haidut

    Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections

    Peat said in one of his interviews that vitamin B2, together with vitamin B1, selenium, vitamin K and CoQ10 are the most important substances for optimal mitochondrial function. I have been researching vitamin B2 and continue to be amazed at how underestimated this nutrient is both in...
    • haidut
    • Thread
    • bacteria bcaa endotoxin fad flavin mononucleotide flavine adenine dinucleotide fmn infection lps riboflavin riboflavin-5-phosphate sepsis survival tlr4 valine vitamin b2
    • Replies: 73
    • Forum: Scientific Studies
  17. haidut

    Endotoxin Can Cause Inflammation Independently Of PUFA

    As many people on the forum know, the primary driver of inflammation in humans is the metabolism of arachidonic acid into various inflammatory mediators like prostaglandins, leukotrienes, and tromboxanes. If you remove arachidonic acid, about 90% of the inflammatory response goes away. However...
  18. haidut

    Dengue Fever/shock May Be Simply An Endotoxin-driven Symptom

    I have been studying endotoxin and its mechanisms lately, so I will post more on that soon. For now, I will just say that endotoxin seems to mediate most of its effects through the so-called TLR4 "receptor". In agreement with Peat's writings about flu and its connection to endotoxin, this study...
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