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Silica, present in most supplements/food, activates the endotoxin receptor (TLR4)

haidut

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Many of my readers know about the health risks of silica - a substance doctors and pundits call completely "benign, present in virtually all commercially sold dietary supplements and also in most commercially sold food (even organic ones!). The most commonly used form commercially is silicon dioxide, which is essentially powdered glass! However, despite its ubiquity, the risks of silica have not been widely studied and warning people about its dangers usually elicits accusations of "conspiracy theories" and/or "fearmongering". However, the dangers of endotoxin (LPS) and of other substances capable of activating its receptor (TLR4) are now becoming publicly known to the point where even general practitioners (GP) and family doctors are starting to advise their patients to not consume foods that result in elevation of LPS in the bloodstream. In light of that knowledge, perhaps the study below will change people's perception on silica being "benign", as it demonstrates that simply inhaling silica (which is an amount much smaller than what is ingested through food/supplements) is capable of activating TLR4 and triggering a systemic inflammatory reaction that not only damaged lungs (duh) but also negatively affected bone metabolism and led to bone loss.

Anti-inflammatory effects of Ac-SDKP on lung macrophages | JIR

"...Results: The data indicated that silica inhalation might activate the RANKL and TLR4 signaling pathways in lung macrophages, thus inducing the lung inflammatory and proteolytic phenotype of macrophages and osteoclasts in lung and bone. Ac-SDKP maintained the lung elastin level by inhibiting lung inflammation and macrophage activation via the RANKL and TLR4 signaling pathways. Ac-SDKP also attenuated the reduction in femoral bone mineral density in silicotic rats by inhibiting osteoclast differentiation via the RANKL signaling pathway. Conclusion: Our findings support the hypothesis that inhalation of crystalline silica induces activation of lung macrophages and bone osteoclasts via the RANKL and TLR4 signaling pathways. Ac-SDKP has the potential to stabilize lung homeostasis and bone metabolism."
 
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Peatness

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The stuff is everywhere it seems. I’m surprised that companies like Life Extension insist on adding silica to a lot of there supplements. Before ray peat I had no idea of the potential harm of this supplement.

 

michael94

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At least the macrophages seem to be helping cleaning up the silica, which should be promising to people with past silica exposure
 

haidut

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The stuff is everywhere it seems. I’m surprised that companies like Life Extension insist on adding silica to a lot of there supplements. Before ray peat I had no idea of the potential harm of this supplement.


Great study, as it confirms the endotoxin angle. Scleroderma is now known to be caused/driven by TLR4 activation and antagonists at that receptor have been shown to treat it (in animal models).
Yeah, I have no idea what justification vendors come up with to put powdered glass into their products. Like, who cares if the powder in a supplement cakes considering it is usually in a capsule and the person ingests the whole capsule and cares none if the powder inside is caked.
 

michael94

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Great study, as it confirms the endotoxin angle. Scleroderma is now known to be caused/driven by TLR4 activation and antagonists at that receptor have been shown to treat it (in animal models).
Yeah, I have no idea what justification vendors come up with to put powdered glass into their products. Like, who cares if the powder in a supplement cakes considering it is usually in a capsule and the person ingests the whole capsule and cares none if the powder inside is caked.
Its not anti clumping for the consumer, but their pill machines
 

haidut

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Its not anti clumping for the consumer, but their pill machines

Lol, silly me! I thought they actually cared about the consumer, even if it was just on paper.
 

Sitaruîm

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I just found Silica is used as an anti caking agent in table salt in Argentina. Let me tell you thag this country is a mine field when it comes to food fortification and odd ingredients
 

Perry Staltic

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I would think there's probably a big difference between ingesting and inhaling silica. And I doubt it's a biochemical activation of TL4, but rather mechanotransduction, i.e., turning a physical force into a biochemical response. The lungs are probably a lot more sensitive to that kind of thing than the digestive system is.
 
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Peatness

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Dr. B

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Many of my readers know about the health risks of silica - a substance doctors and pundits call completely "benign, present in virtually all commercially sold dietary supplements and also in most commercially sold food (even organic ones!). The most commonly used form commercially is silicon dioxide, which is essentially powdered glass! However, despite its ubiquity, the risks of silica have not been widely studied and warning people about its dangers usually elicits accusations of "conspiracy theories" and/or "fearmongering". However, the dangers of endotoxin (LPS) and of other substances capable of activating its receptor (TLR4) are now becoming publicly known to the point where even general practitioners (GP) and family doctors are starting to advise their patients to not consume foods that result in elevation of LPS in the bloodstream. In light of that knowledge, perhaps the study below will change people's perception on silica being "benign", as it demonstrates that simply inhaling silica (which is an amount much smaller than what is ingested through food/supplements) is capable of activating TLR4 and triggering a systemic inflammatory reaction that not only damaged lungs (duh) but also negatively affected bone metabolism and led to bone loss.

Anti-inflammatory effects of Ac-SDKP on lung macrophages | JIR

"...Results: The data indicated that silica inhalation might activate the RANKL and TLR4 signaling pathways in lung macrophages, thus inducing the lung inflammatory and proteolytic phenotype of macrophages and osteoclasts in lung and bone. Ac-SDKP maintained the lung elastin level by inhibiting lung inflammation and macrophage activation via the RANKL and TLR4 signaling pathways. Ac-SDKP also attenuated the reduction in femoral bone mineral density in silicotic rats by inhibiting osteoclast differentiation via the RANKL signaling pathway. Conclusion: Our findings support the hypothesis that inhalation of crystalline silica induces activation of lung macrophages and bone osteoclasts via the RANKL and TLR4 signaling pathways. Ac-SDKP has the potential to stabilize lung homeostasis and bone metabolism."
mate what about Palmitic acid activating the TLR4 receptor and omega 3 having anti endotoxin effects? why would a SFA apparently increase endotoxin while omega 3 reduces?
also what was that word Ray used regarding silica and other nano particles, he even used it in reference to charcoal supplements. was it perfusion, perforation? some word like that.
 

Lilac

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what was that word Ray used regarding silica and other nano particles, he even used it in reference to charcoal supplements. was it perfusion, perforation? some word like that.

Persorption.
 

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