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oxphos
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Thiamine+biotin can treat Huntington Disease (HD), by restoring glucose metabolism
Many carrot-salads ago, back in ancient pre-pandemic times, I posted a study on high-dose biotin (300mg daily) stopping the so-called primary-progressive multiple sclerosis (PPMS) - the most aggressive variant of this "autoimmune" illness. The proposed mechanism of action for the benefit seen in...- haidut
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- atp biotin huntington myelin oxphos thiamine vitamin b1
- Replies: 7
- Forum: Scientific Studies
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The "cancer metabolism" drives aging in humans
A truly monumental study, as it is perhaps the first one to demonstrate that "aging" in human cells is entirely under metabolic control. What can I say - Ray Peat right again! Unfortunately, the way the actual study has been worded has been, once again, criminally mis-represented by mainstream...- haidut
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- aging cancer glycolysis lifespan mitohondria oxphos
- Replies: 18
- Forum: Scientific Studies
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Neuron/brain growth depends on metabolism (OXPHOS)
As many of my readers know, the mainstream medical dogma is that the number of neurons in the human grain increases until early adulthood, after which it stops completely. Thus, medicine views the adult human brain as having a fixed number of neurons and any damage to them or complete loss of...- haidut
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- brain differentiation growth mitochondria neuron oxphos
- Replies: 1
- Forum: Scientific Studies
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Major depression likely driven by mitochondrial deterioration/dysfunction
This the latest study demonstrating that not only are various chronic diseases and aging essentially the same process, but that this process is fundamentally bioenergetic in nature. Namely, dysfunctional mitochondria, leading to low OXPHOS, is the direct cause of many physiological and "mental"...- haidut
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- aging bioenergetics depression gdf-15 mitochondria oxphos senescence senolytic
- Replies: 4
- Forum: Scientific Studies
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Harvard Psychiatrist: All Mental Disease is Metabolic/Bioenergetic Disease
It is always nice to see mainstream medicine plagiarize from Dr. Peat attempt to right its course after decades-long mistakes. While the genetic dogma still rules supreme in medicine's attitude towards most "physical" diseases, the utter failure of the "serotonin hypothesis" and its dear...- haidut
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- diet energy mental disease mental health mitochondria oxphos stress
- Replies: 32
- Forum: Scientific Studies
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Nice video on the electron transport chain!
View: https://www.youtube.com/watch?v=UyTto4Aegss Really enjoyed this video - there were some holes in my understanding that I wanted to fill up. I'm sure it's not perfect, but I still found it useful.- EnergeticLeo
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- oxphos
- Replies: 0
- Forum: Metabolism
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Diabetes, Alzheimer's, cancer are bioenergetic diseases; PUFA may be the cause
The bad news for PUFA (in this case linoleic acid) just keep piling on. At this point, there is hardly a chronic condition out there that has not been linked to elevated PUFA and/or their peroxidation products. The first study below makes the argument that PUFA peroxidation byproducts (created...- haidut
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- 4-hydroxynonenal alzheimer cancer diabetes mitochondria oxphos pufa ros
- Replies: 1
- Forum: Scientific Studies
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Impaired OXPHOS by high ketones drives heart failure
Just a few weeks after my post on how excessive fatty acid oxidation (FAO) drives cancer, below is another great new study, which corroborates once again the hypothesis that excessive FAO (and/or fatty acid supply into the mitochondria of the cell) result in impaired OXPHOS and organ damage...- haidut
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- fao fatty acid oxidation heart failure ketone krebs mitochondria oxphos succinate
- Replies: 4
- Forum: Scientific Studies
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Disrupting mitochondrial function can cause severe anemia
Most doctors consider anemia mostly an iron-related issue, despite the fact that iron supplementation often fails to correct the condition, even in people with true iron deficiency anemia (e.g. low iron saturation index, low ferritin, high transferin). The role of bioenergetics is rarely...- haidut
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- anemia hematopoiesis mitochondria oxphos rbc thyroid
- Replies: 1
- Forum: Scientific Studies
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B
Doxycycline Impairs Cardiac Mitochondrial and Contractile Function
Mice treated with doxycycline showed mitochondrial complex I dysfunction, reduced OXPHOS capacity and impaired diastolic function. Doxycycline exacerbated diastolic dysfunction and reduced ejection fraction in a diabetes mouse model vulnerable for metabolic derangements. We therefore conclude...- bobbity
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- cardiac doxycycline mitochondrial function oxphos
- Replies: 3
- Forum: Heart, Heart Rate, Blood Pressure
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Cancer relies on fat as fuel due to high reductive stress
One of the few studies out there that not only links cancer with impaired OXPHOS, but demonstrates directly the role of reductive stress (exemplified by the NAD/NADH ratio) in cancer's appetite for fats as fuel required for the cancer survival and proliferation/metastasis. It also once again...- haidut
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- cancer fat fatty acid oxidation nad nad/nadh oxphos oxygen redox
- Replies: 11
- Forum: Scientific Studies
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No evidence for rate-of-living theory of aging
Just a quick post, since this topic dominates anti-aging research - i.e. despite lack of concrete evidence for it, mainstream research (and finding agencies) continue to claim that longevity is tied to metabolism, but in an inverse relationship. The study below is on turtles - one of the longest...- haidut
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- aging endotherm lifespan longevity oxphos turtle
- Replies: 10
- Forum: Scientific Studies
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Reductive stress drives pathogenesis and progression of tuberculosis
I am posting this study b/c it is one of the few I have seen lately demonstrating that even infectious diseases are metabolic in origin. Of course, a pathogen is involved as well, but as it turns out it may not be able to cause an infection by itself. For that to happen, a metabolic dysfunction...- haidut
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- etc infection inflammation oxphos ros tnf-a tuberculosis
- Replies: 0
- Forum: Scientific Studies
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Vitamin B1 as a potential treatment for Alzheimer's Disease (AD)
After decades of denial that AD is a metabolic condition, Big Pharma and Big Govt, are silently doing an 180-degree turn by secretly funding university clinical trials for metabolic interventions in that disease. The study below will evaluate the effects of benfotiamine - a lipophilic analog of...- haidut
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- alzheimer benfotiamine dementia diabetes glucose oxphos thiamine
- Replies: 27
- Forum: Scientific Studies
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BOMBSHELL: Serotonin High in Depression, Not a "Happy" Chemical, Lowers Energy, Depression Self-Resolves
When I first saw the article pop up in my feed, I could hardly believe my eyes that a mainstream mouthpiece of Big Pharma will publish such frank admission of psychiatry's utter failure - i.e. the claims in regards to serotonin (5-HT), its role in mental illness, and even its social "label". In...- haidut
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- 5-ht depression energy oxphos serotonin ssri suicide
- Replies: 32
- Forum: Scientific Studies
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Low-dose niacinamide has striking anti-obesity effects
It looks like the medical world has firmly set its sights on the bioenergetic wave/target, as the number of scientific papers focusing on niacinamide, NAD/NADH ratio and OXPHOS in general has been steadily climbing since 2010. That would be good news, despite the attempts of companies such as...- haidut
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- co2 nad nampt niacinamide nicotinamide obesity oxphos vitamin b3
- Replies: 189
- Forum: Scientific Studies
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Hypogonadism in older males due to low OXPHOS
I suspect many readers will simply say "duh!", but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the...- haidut
- Thread
- aging co2 hypogonadism male oxphos precursor testosterone
- Replies: 9
- Forum: Scientific Studies
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Stem cells availability, and their differentiation, depend on metabolism
Once again, the master controller role metabolism plays in human life is revealed in yet another experiment. The study below demonstrated that the degree of cell "stemness", as well as its differentiation into a specific organ/tissue depends entirely on the metabolic rate of the cell, and thus...- haidut
- Thread
- cancer differentiation mitochondria mitosis morphogenesis oxphos stem cell
- Replies: 1
- Forum: Scientific Studies
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PUFA cause obesity, diabetes, autism, Alzheimer's disease, anxiety, and depression
The title is an actual quote from the article, so there is no editorializing on my part and it speaks volumes about how the authors feel about their findings. In addition, opposite effects were found for saturated fats, in this case coconut oil, which leads the authors to once again remind...- haidut
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- alzheimer autism depression diabetes oxphos pufa soybean oil
- Replies: 3
- Forum: Scientific Studies
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Epilepsy/seizures caused by energetic deficit leading to calcium overload
Yet another study demonstrating that not only is a chronic, "incurable" disease of unknown origin treatable but that its main cause is energetic/metabolic and linked to impaired glucose metabolism. Specifically, the study demonstrated that impaired pyruvate transport into the mitochondria is...- haidut
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- calcium epilepsy glucose ketogenic mitochondria oxphos pyruvate seizure
- Replies: 3
- Forum: Scientific Studies