Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

[bobbity]

Mice treated with doxycycline showed mitochondrial complex I dysfunction, reduced OXPHOS capacity and impaired diastolic function. Doxycycline exacerbated diastolic dysfunction and reduced ejection fraction in a diabetes mouse model vulnerable for metabolic derangements. We therefore conclude that doxycycline impairs mitochondrial function and causes cardiac dysfunction.

The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and ...

www.ncbi.nlm.nih.gov

Contradicted by,

Protecting mitochondria from oxidative stress, and the regulation of mitochondrial dynamics by drugs that shift the balance toward fusion, could be a novel therapeutic approach for heart failure. On the basis of our findings, we raise the possibility that DOX could be a novel therapeutic agent in the future treatment of heart failure.

Doxycycline protects against ROS-induced mitochondrial fragmentation and ISO-induced heart failure

In addition to their anti-bacterial action, tetracyclines also have complex biological effects, including the modification of mitochondrial protein synthesis, metabolism and gene-expression. Long-term clinical studies have been performed using tetracyclines, without significant side effects...

journals.plos.org

I am rather dubious about the former study, I wonder any forum members might have some insights regarding this issue (looking at you @haidut )

 

[Perry Staltic]

in a diabetes mouse model vulnerable for metabolic derangements

This statement in the first study makes me not pay much attention to it

 

[yerrag]

Considering that the mitochondria used to be a bacteria that developed from two prokaryotic cells into a eukaryotic cell, and that tetracycline a class antibiotics suppress bacterial multiplication, and bacteria are prokaryotic cells, one cannot discount the negative effect of using doxycycline on the mitochondria. So I think caution is warranted.

 

[bobbity]

Considering that the mitochondria used to be a bacteria that developed from two prokaryotic cells into a eukaryotic cell, and that tetracycline a class antibiotics suppress bacterial multiplication, and bacteria are prokaryotic cells, one cannot discount the negative effect of using doxycycline on the mitochondria. So I think caution is warranted.

Thank you for this reply!