Which of these would be the most dopaminergic and least serotonergic simultaneously?

[lateralus]

So between 10-Methoxy-Harmalan, Mirtazapine, Nortriptyline, Metergoline, Cyproheptadine and Lisuride, which is the best serotonin antagonist to run indefinitely for maximum disinhibition of dopamine release?

 

[liam183]

So between 10-Methoxy-Harmalan, Mirtazapine, Nortriptyline, Metergoline, Cyproheptadine and Lisuride, which is the best serotonin antagonist to run indefinitely for maximum disinhibition of dopamine release?

Don't do drugs kids

 

[lateralus]

Don't do drugs kids

Am I supposed to laugh? None of these are recreational bud

 

[mostlylurking]

So between 10-Methoxy-Harmalan, Mirtazapine, Nortriptyline, Metergoline, Cyproheptadine and Lisuride, which is the best serotonin antagonist to run indefinitely for maximum disinhibition of dopamine release?

Thiamine.

The Beneficial Role of Thiamine in Parkinson Disease

Parkinson disease () is the second most common form of neurodegeneration among elderly individuals. is clinically characterized by tremors, rigidity, slowness of movement, and postural imbalance. In this paper, we review the evidence for an association ...

www.ncbi.nlm.nih.gov

Studies have suggested a relationship gbetween dopamine and thiamine, dopamine has been shown to suppress the mouse‐killing aggression (muricide) induced by a thiamine‐deficient (TD) diet 1, and this suppressive effect can be potentiated by carbidopa 2. Patients with PD who have undergone levodopa (L‐dopa) therapy show significantly higher cerebrospinal fluid (CSF) levels of thiamine diphosphate (TDP) and total thiamine than do patients who are not treated with this drug 3. Moreover, thiamine deficiency can decrease the concentration of dopamine in the striatum, whereas animals that are fed a diet containing 5% ethanol show increased dopamine turnover 4. In an animal experimental study of thiamine deficiency, region‐specific vesicular dysfunction, that is, a decreased level of dopamine metabolite, was observed posttreatment 5. Intrastriatal administration of thiamin triphosphate (TTP) or TDP has been shown to induce dopamine release 6, and thiamine derivatives are known to be present in high concentrations in the human SN 7. Dopamine release can be induced by the intrastriatal administration of TPP or TDP, reaching levels that are as high as 1400% and 249% of the basal levels, respectively, whereas reduced levels of dopamine in the striatum can occur in thiamine deficiency 6. Furthermore, decreased CSF‐free thiamine levels were noted in patients with PD as compared to controls 3. In parkinsonism‐dementia patients, thiamine pyrophosphatase activity was found to be significantly reduced in the frontal cortex 8. In addition, Gold et al. 9 reported that 70% and 33% of their patients with PD had low plasma thiamine and low RBC thiamine levels, respectively. Starvation‐induced TD encephalopathy may also cause symmetrical lesions in the SN 10. Together, these findings suggest that thiamine may play a role in DA neuron activity. Interestingly, parental thiamine administration was used successfully in 9 nonalcoholic patients who presented with acute neurological disorders 11
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Thiamine is needed to lower serotonin in the brain.

Effect of thiamine deficiency on brain serotonin turnover - PubMed

Serotonin turnover has been investigated in regional brain areas of rats made thiamine deficient by pyrithiamine (PT). Following intracisternal injection of [14C]5-hydroxytryptamine ([14C]5-HT), a marked increase in the accumulation of [14C]5-hydroxyindoleacetic acid ([14C]5-HIAA) was found in...

pubmed.ncbi.nlm.nih.gov

also:

Serotonin Syndrome and Thiamine: Is There a Connection? - Hormones Matter

A mild deficiency of thiamine is responsible for the large number of the polysymptomatic illnesses reported.

www.hormonesmatter.com

also:

Thiamine Deficiency Increases Serotonin Synthesis, Inhibits Uptake

I recently had a great experience with thiamine with regards to mental energy, and got curious as to why and how. Found some cool studies on the thiamine-serotonin connection; Thiamine deficiency: selective impairment of the cerebellar serotonergic system. - PubMed - NCBI To explore the role...

raypeatforum.com

 

[Logan-]

So between 10-Methoxy-Harmalan, Mirtazapine, Nortriptyline, Metergoline, Cyproheptadine and Lisuride, which is the best serotonin antagonist to run indefinitely for maximum disinhibition of dopamine release?

Of these, cypro is a dopamine antagonist.

Bromocriptine is a strong dopaminergic, though it isn’t on your list.

You can also research Deprenyl.

Deprenyl – Peatarian-Safe?

Has anyone asked Ray Peat his opinion about this drug? Would he think it is safe for long term usage? Do you think it is safe, and good to use as a nootropic?

raypeatforum.com

Personally, I wouldn’t consider taking any of these drugs lightly.

Meditation has been shown to be dopaminergic in studies.

Vitamin B6, calcium, salt, vitamin D, sunlight, bright incandescent light are pro-dopaminergic. Thyroid has a regulatory, balancing effect.

 

[max93]

Does anyone have experience with nortriptyline? A friend is taking it for migraines, and I'm trying to understand it from a bioenergetic point of view. Any insight would be appreciated!

 

[Logan-]

Does anyone have experience with nortriptyline? A friend is taking it for migraines, and I'm trying to understand it from a bioenergetic point of view. Any insight would be appreciated!

Does it work?

 

[max93]

Does it work?

He just started. Too early to tell, but not feeling very good right off the bat, so I'm skeptical.

Seems that it's recommended for migraine treatment by many doctors, so I'm trying to do some research and see if anyone else has experiences.