Thymus growth inhibited by Test/Estrogen but not by DHT

[Jamsey]

I was reading this post

6-keto P4 - Liquid 6-ketoprogesterone For Lab/R&D

As many forum users know, preventing tissue destruction as a result of hypothyroidism and stress is one of the main topics the pro-metabolic approach focuses on. While tissue catabolism can be drive by a number of mediators working in tandem, the main catabolic steriod in the human organism is...

raypeatforum.com

Haidut talks about thymus suppression by AAS. I started thinking about whether this was applicable to DHT and found this study

Effects of an aromatase inhibitor on testosterone-induced inhibition of thymus growth in immature female rats - PubMed

The hypothesis was tested that the inhibitory action of testosterone on thymus growth is mediated by its metabolism to oestradiol. Immature female rats were given s.c. implants of silicone elastomer tubing containing 5 or 20 mg testosterone alone, or together with 25 or 50 mg of an aromatase...

pubmed.ncbi.nlm.nih.gov

“Thymus growth was inhibited by both doses of testosterone and by oestradiol, but not by DHT.”

“The inhibitory action of testosterone on the growing thymus may be due, at least in part, to its conversion to oestradiol.”

 

[brightside]

Makes sense. Therefore, not only cortisol, but excess estrogen is bad for the thymus.
Actually, I just saw this in the “Similar threads” section

Estrogen And Cortisol, Not Androgens, Suppress Immunity

There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the...

raypeatforum.com

Seems haidut was already on top of that haha

 

[Jamsey]

Makes sense. Therefore, not only cortisol, but excess estrogen is bad for the thymus.
Actually, I just saw this in the “Similar threads” section

Estrogen And Cortisol, Not Androgens, Suppress Immunity

There is a very famous theory in reproductive biology still considered the dominant one in its field. Namely, males have to accept a trade-off between androgen levels and immunity. It is known as the immunocompetence handicap hypothesis (ICHH). Higher androgen levels, the theory goes, allow the...

raypeatforum.com

Seems haidut was already on top of that haha

Ah ***t hahah it hard to find things that haidut hasn’t already found. Yeah as far as I understand estrogen stimulates cortisol release so it makes sense. Dht is supposedly anti cortisol as well.

 

[brightside]

Ah ***t hahah it hard to find things that haidut hasn’t already found. Yeah as far as I understand estrogen stimulates cortisol release so it makes sense. Dht is supposedly anti cortisol as well.

Haha I don’t know how he manages to cover everything.

Yep, good stuff!

 

[golder]

What would be some good restorative methods for building the thymus for those of us that are slowly rebuilding from a hypothyroid and high cortisol state for decades?

 

[Jamsey]

What would be some good restorative methods for building the thymus for those of us that are slowly rebuilding from a hypothyroid and high cortisol state for decades?

Haidut to the rescue

Reducing Estrogen Synthesis Regenerates Thymus Destroyed By Aging

Recently, I posted a thread showing that immune dysfunction (thymus shrinkage) which developed with aging (and excess of PUFA, estrogen, cortisol) explains cancer incidence much better than any genetic model. Immune Dysfunction (cortisol/estrogen/PUFA), Not Genetics, Causes Cancer The quote...

raypeatforum.com

Glucose Is Anabolic For Thymus, Opposes Catabolic Effects Of Cortisol

As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone, and even DHT (but not by testosterone). The...

raypeatforum.com

Seems that main methods include reducing/blocking cortisol and cortisol stimulation(estrogen/pufa). Protective chemicals such as pregnenolone/dhea/dht/thyroid/glucose that block or inhibit cortisol release should help the thymus rebuild.