New Study: Vitamin D causes melanoma

[ysdj]

Circulating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study​

...The MR analysis showed no causal relationship between circulating vitamin D concentrations and most types of cancer, except for a causal relationship with melanoma skin cancer (MSC) (odds ratio [OR]IVW = 1.003, 95% confidence intervals [CI] 1.001–1.005, P = 0.004).
...Our findings provide support for a causal relationship between circulating vitamin D concentration and risk of MSC.

Circulating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study - Journal of Cancer Research and Clinical Oncology

Causal association between serum 25-Hydroxyvitamin D levels and cutaneous melanoma: a two-sample Mendelian randomization study​

...The MR analysis provided substantial evidence of a positive causal relationship between serum 25-Hydroxyvitamin D levels and the incidence of cutaneous melanoma, suggesting that each unit increase in serum 25-Hydroxyvitamin D levels corresponds with an increased risk of melanoma.
...The findings indicated a potentially causal positive association between serum 25-Hydroxyvitamin D levels and melanoma risk, challenging traditional beliefs about vitamin D’s role in melanoma.

Causal association between serum 25-Hydroxyvitamin D levels and cutaneous melanoma: a two-sample Mendelian randomization study

 

[mosaic01]

Read: Sun makes PUFA-saturated and iron-toxic people develop melanoma while also increasing the storage form of vitamin D as a side effect of sun exposure.

 

[ysdj]

Read: Sun makes PUFA-saturated and iron-toxic people develop melanoma while also increasing the storage form of vitamin D as a side effect of sun exposure.

This is a Mendelian randomization study, eliminating the confounding factor of sunlight.

 

[GTW]

Lies, damn lies, statistics.
"Potentially causal"
"Relatively small association"
Assuming a linear relationship. (I was suspicious of this already, since it implies that increase in vitamin D even at deficiency level promotes melanoma.)
>Additionally, our study did not account for individual-level confounders, nor did it explore potential non-linear relationships between serum 25-Hydroxyvitamin D levels and melanoma risk. The study also overlooked the modulatory roles of factors like age, sex, and environmental UV exposure, given its reliance on summarized population-level data. Moreover, our analysis assumes a linear relationship between exposure and outcome, which may oversimplify the biological reality.

 

[lamassu]

This is a Mendelian randomization study, eliminating the confounding factor of sunlight.

Can you elaborate on why Mendelian randomization eliminates environmental confounders like sunlight?

 

[Ras]

They're really getting desperate.

 

[Sitaruîm]

Circulating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study​

...The MR analysis showed no causal relationship between circulating vitamin D concentrations and most types of cancer, except for a causal relationship with melanoma skin cancer (MSC) (odds ratio [OR]IVW = 1.003, 95% confidence intervals [CI] 1.001–1.005, P = 0.004).
...Our findings provide support for a causal relationship between circulating vitamin D concentration and risk of MSC.

Circulating vitamin D concentration and risk of 14 cancers: a bidirectional Mendelian randomization study - Journal of Cancer Research and Clinical Oncology

Causal association between serum 25-Hydroxyvitamin D levels and cutaneous melanoma: a two-sample Mendelian randomization study​

...The MR analysis provided substantial evidence of a positive causal relationship between serum 25-Hydroxyvitamin D levels and the incidence of cutaneous melanoma, suggesting that each unit increase in serum 25-Hydroxyvitamin D levels corresponds with an increased risk of melanoma.
...The findings indicated a potentially causal positive association between serum 25-Hydroxyvitamin D levels and melanoma risk, challenging traditional beliefs about vitamin D’s role in melanoma.

Causal association between serum 25-Hydroxyvitamin D levels and cutaneous melanoma: a two-sample Mendelian randomization study

These odd ratios are essentially 1. This study proves, essentially, that vitamin D does not increase the risk of cancer.

 

[ysdj]

Can you elaborate on why Mendelian randomization eliminates environmental confounders like sunlight?

MR is a genetics study showing that genetically determined high vitamin D is causally linked to increased risk of melanoma, apparently independent of sunlight

 

[Snicky]

Interesting. My boss just had her first patch of melanoma removed from her back. She works in an office, and lives in a dark upper floor apartment with no terrace, is definitely not a sunbather but does like the Mediterranean landscape we live in.

She also has terrible teeth and joints, both of which are always getting surgical interventions.

I don’t know why, but I suspect she has a lot of endotoxin issues…

I thought the melanoma might be related to the

 

[TheSir]

I believe it. Vitamin D is the most shilled supplement. It's too popular to be beneficial. In a society of lies, popularity is the hallmark of harmfulness.

 

[lamassu]

MR is a genetics study showing that genetically determined high vitamin D is causally linked to increased risk of melanoma, apparently independent of sunlight

Thank you. I guess then my question is how to determine that the variation in vitamin D levels are genetically determined? How does the vitamin D level vary by allele? Is it a good correlation? Genuine question here so if you have anything I could read on this subject I'd be grateful.

 

[ysdj]

You can calculate the effects of different genes on vitamin D concentrations from large biological databases such as UK Biobank

Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci

Thank you. I guess then my question is how to determine that the variation in vitamin D levels are genetically determined? How does the vitamin D level vary by allele? Is it a good correlation? Genuine question here so if you have anything I could read on this subject I'd be grateful.

 

[GTW]

>Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.

 

[LLight]

I haven't fully understood MR methodology but apparently there are some necessary hypotheses that should be verified for MR to work and it's not always the case.

 

[GTW]

Given the authors' own disclaimers it's not worth discussing the relevance to you, me, or any other individual person.

 

[lamassu]

You can calculate the effects of different genes on vitamin D concentrations from large biological databases such as UK Biobank

Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci

Thanks I'll check this out. I'm also curious in how they discriminate between environmental and genetic factors ie. what is the contribution of each