Methylene Blue For The Brain: Sustained-attention, Short-term Memory, Enhanced Memory Retrieval


Nov 21, 2015
London, UK
New reference for Methylene Blue.

Press coverage: Old drug may offer new answers in the fight against Alzheimer's

Purpose: To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain.

Results: Administration of methylene blue increased response in the bilateral insular cortex during a psychomotor vigilance task (Z = 2.9–3.4, P = .01–.008) and functional MR imaging response during a short-term memory task involving the prefrontal, parietal, and occipital cortex (Z = 2.9–4.2, P = .03–.0003). Methylene blue was also associated with a 7% increase in correct responses during memory retrieval (P = .01).

Conclusion: Low-dose methylene blue can increase functional MR imaging activity during sustained attention and short-term memory tasks and enhance memory retrieval.

Pubmed: Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain. - PubMed - NCBI

Source: RSNA Publications Online


Mar 18, 2013
USA / Europe
@haidut - For your review to add to the Oxidal reference list if relevant.

Thanks, it's good to see others are also keeping up with the news on MB :):


Feb 21, 2016
@ejalrp, it's on page 3 of the PDF: "Then, 13 participants (the methylene blue group) were randomized to receive 280 mg (approximately 4 mg/kg) of oral U.S. Pharmacopeia-grade methylene blue (methylthioninium chloride USP; PCCA, Houston Tex), [...]"


Jul 22, 2012
@ejalrp, it's on page 3 of the PDF: "Then, 13 participants (the methylene blue group) were randomized to receive 280 mg (approximately 4 mg/kg) of oral U.S. Pharmacopeia-grade methylene blue (methylthioninium chloride USP; PCCA, Houston Tex), [...]"

Hardly low-dose :>)


Feb 21, 2016
Hardly low-dose :>)

Yes, Haidut has commented on that in the other thread discussing the study. ;)

Rodriguez et al. contrast low- vs. high doses as follows:

"The 280-mg dose selection was estimated as 4 mg/kg for an average body weight of 70 kg. Methylene blue is a memory-enhancing drug in animals and humans after a single dose in the low-dose range of 0.5-4 mg/kg, but it has opposite effects at doses greater than 10 mg/kg and displays a hormetic dose response (15)."
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