Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression

[tasfarelel]

I only read the abstract, but it sounds good than longterm amoxicillin use downregulates some immunoglobulin gene and may lead to long lasting changes trough methylation (whatever those changes are): Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes - PubMed

 

[xeliex]

Synchronistically to your post, I started taking amoxi last week for ear pain. Seems like a mid ear infection or something.
I was taking about 1000mg daily. I did feel psychologically better and started having ghost wipes. Temperatures went up. I tolerated milk with no issues. Bloat resolved. Etc... It was good. But I just stopped because I started getting diarrhea.

The nagging ear pain is still there though.

 

[Smitty]

Synchronistically to your post, I started taking amoxi last week for ear pain. Seems like a mid ear infection or something.
I was taking about 1000mg daily. I did feel psychologically better and started having ghost wipes. Temperatures went up. I tolerated milk with no issues. Bloat resolved. Etc... It was good. But I just stopped because I started getting diarrhea.

The nagging ear pain is still there though.

S. boulardii is safe and effective at stopping antibiotic induced diarrhea. Letting an infection fester is less than ideal!

 

[Elie]

I wonder how long is it safe to use amoxicillin, It has been a life saver in terms of teeth infections and pan. I can have the worse pain and a 7-10 day course (500 mg three times daily) will provide relief for months.
it is kills both gram positive and negative bacteria

 

[David PS]

Here is the full text.

Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes

Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients (n = 100) receiving amoxicillin treatment...

www.mdpi.com

 

[tasfarelel]

@Elie - I cannot answer your question - but try a mouthwash with any antibiotic instead. This will provide faster relief. Antibiotics don't reach effective concentrations in the saliva. I crush usually a penicillin tab with an aspirin add minimal water and rotate for 30min. Any pain/inflammation is gone over night.

 

[xeliex]

@Elie - I cannot answer your question - but try a mouthwash with any antibiotic instead. This will provide faster relief. Antibiotics don't reach effective concentrations in the saliva. I crush usually a penicillin tab with an aspirin add minimal water and rotate for 30min. Any pain/inflammation is gone over night.

That's brilliant.

 

[Elie]

@Elie - I cannot answer your question - but try a mouthwash with any antibiotic instead. This will provide faster relief. Antibiotics don't reach effective concentrations in the saliva. I crush usually a penicillin tab with an aspirin add minimal water and rotate for 30min. Any pain/inflammation is gone over night.

Interesting.
Here are a few questions.

What do you mean by rotate for 30 min? Swish for 30 min?
How often do you do this?

the amoxicillin I have is encapsulated.

Do you think that emptying the capsule's content will work the same?

 

[Elie]

I only read the abstract, but it sounds good than longterm amoxicillin use downregulates some immunoglobulin gene and may lead to long lasting changes trough methylation (whatever those changes are): Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes - PubMed

increased methylation is associated with increased risk for cancer, isn't it?

 

[tasfarelel]

Yes, swish I guess (rarely use such wording) and emptying the capsule will work. Sometimes I need to do this 2 - 3 times until the inflation is gone / depends how fast I realized something is going on.

Re. methylation - I saw in the forum here a knowledgeable seeming post that I didn't manage to read to the end - may you try to find it. Else, methylation cannot be seen back/white, in reality it depends which regions are targeted.

 

[Explorer]

Anyone knows where to buy amoxicilin and antibiotics/antifungals like fluconazole generally in EU online without prescription? I felt a lot better and also erections were harder (usually they are a bit less hard the next day after ejaculating but on Amoxicilin even if I ejaculated I could get as strong erections as usually before only on days of nofap/semen retention, even if 24 hours hadn't passed since the last ejaculation also the POIS post orgasmic illness syndrome symptoms improved - less brain fog, felt more energized, less inflamed and better gut health overall)

There must be some online store that ships from within EU antibiotics/antifungals or gets them into EU without it getting seized or something

I'd be very grateful if someone can send a link that has been used by many with good success, it would help me a lot especially getting Fluconazole (did I spell it right?) as many with POIS post orgasmic illness syndrome on POIS forums like /r/POIS and POISCenter.com have 100% fully cured themselves with antibiotics or antifungals especially Amoxicilin and Fluconazole