Is Mucuna Pruriens seeds high in 5-HTP? Is Mucuna Pruriens serotonergic?

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Enhanced

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Potential Anti-Anxiety Effect of Mucuna pruriens in Experimental Model of Swiss Albino Mice. | PTB Reports

www.ptbreports.org www.ptbreports.org

Previous studies reported that, MP contains L-DOPA and 5-hydroxy tryptophan (5-HTP) as a major constituent with higher concentration in seeds [21,22].
Click to expand...
There are many similar studies with the above quote that cites this 1971 study that you can't seem to find anymore (if anyone knows how I would be happy) Seeds as sources of L-dopa - PubMed
I can't seem to find anywhere about how much 5-HTP there is in the seeds. If it would be significant enough to cause an effect.

link.springer.com

Investigation of noradrenaline and serotonin mediated antidepressant action of Mucuna pruriens (L) D.C seeds using various experimental models - Advances in Traditional Medicine

The effect of antidepressant treatments have traditionally been discussed primarily in terms of effects on noradrenergic and serotonergic systems. Mucuna Pruriens L (D.C) (Leguminoseae) is widely used in Indian folk medicine in variety of disease conditions. Based on nervous protective action of...
link.springer.com link.springer.com
As shown in Table 6, significant (p<0.001) increase in brain serotonin concentration was observed with 14 days MPE (200 mg/kg, p.o.) treatment as compared to control.
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There was another study that showed increased dopamine, serotonin and norepinephrine levels after chronic treatment, and that study linked the increase with neuroprotective properties of MP. 14 days in this study kind of seems short for such an effect to take place, it was done on mice though. Anyone wanna chime in? Do you guys think a Mucuna Pruriens seed extract will directly increase serotonin?
 
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mostlylurking

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Enhanced said:

Potential Anti-Anxiety Effect of Mucuna pruriens in Experimental Model of Swiss Albino Mice. | PTB Reports

www.ptbreports.org www.ptbreports.org


There are many similar studies with the above quote that cites this 1971 study that you can't seem to find anymore (if anyone knows how I would be happy) Seeds as sources of L-dopa - PubMed
I can't seem to find anywhere about how much 5-HTP there is in the seeds. If it would be significant enough to cause an effect.

link.springer.com

Investigation of noradrenaline and serotonin mediated antidepressant action of Mucuna pruriens (L) D.C seeds using various experimental models - Advances in Traditional Medicine

The effect of antidepressant treatments have traditionally been discussed primarily in terms of effects on noradrenergic and serotonergic systems. Mucuna Pruriens L (D.C) (Leguminoseae) is widely used in Indian folk medicine in variety of disease conditions. Based on nervous protective action of...
link.springer.com link.springer.com

There was another study that showed increased dopamine, serotonin and norepinephrine levels after chronic treatment, and that study linked the increase with neuroprotective properties of MP. 14 days in this study kind of seems short for such an effect to take place, it was done on mice though. Anyone wanna chime in? Do you guys think a Mucuna Pruriens seed extract will directly increase serotonin?
Click to expand...
Are you trying to increase serotonin? If yes, can you explain why?
 
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mostlylurking

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Enhanced said:
I was worried about it, I'm thinking of supplementing it.
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I'd like to suggest you learn about serotonin first. It's not something you want to increase.
suggested reading:

Serotonin: Effects in disease, aging and inflammation

In the early 1950s, several people recognized that the symptoms produced by administering an excess of serotonin were similar to those experienced by people with intestinal tumors called argentaffinomas or carcinoid tumors, which are usually in the small intestine or appendix.
raypeat.com

Serotonin, depression, and aggression - The problem of brain energy.

Serotonin research is relatively new, but it rivals estrogen research for the level of incompetence and apparent fraudulent intent that can be found in professional publications. This is partly because of the involvement of the drug industry, but the U.S. government also played a role in setting...
raypeat.com

Tryptophan, serotonin, and aging

Beginning with the industrial production of glutamic acid (sold as MSG, monosodium glutamate), the public has been systematically misinformed about the effects of amino acids in the diet.
raypeat.com
 
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E

Enhanced

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Joined
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Messages
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Location
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mostlylurking said:
I'd like to suggest you learn about serotonin first. It's not something you want to increase.
suggested reading:

Serotonin: Effects in disease, aging and inflammation

In the early 1950s, several people recognized that the symptoms produced by administering an excess of serotonin were similar to those experienced by people with intestinal tumors called argentaffinomas or carcinoid tumors, which are usually in the small intestine or appendix.
raypeat.com

Serotonin, depression, and aggression - The problem of brain energy.

Serotonin research is relatively new, but it rivals estrogen research for the level of incompetence and apparent fraudulent intent that can be found in professional publications. This is partly because of the involvement of the drug industry, but the U.S. government also played a role in setting...
raypeat.com

Tryptophan, serotonin, and aging

Beginning with the industrial production of glutamic acid (sold as MSG, monosodium glutamate), the public has been systematically misinformed about the effects of amino acids in the diet.
raypeat.com
Click to expand...
Oh I meant it the opposite way. I was worried about Mucuna Pruriens potentially increasing serotonin as an adverse effect, as I'm thinking of supplementing it. I already have first-hand experience with serotonin reuptake inhibitors affecting me very badly.
 
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mostlylurking

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Messages
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Enhanced said:
Oh I meant it the opposite way. I was worried about Mucuna Pruriens potentially increasing serotonin as an adverse effect, as I'm thinking of supplementing it. I already have first-hand experience with serotonin reuptake inhibitors affecting me very badly.
Click to expand...
Why do you want to take Mucuna Pruriens?
 
M

mostlylurking

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Joined
May 13, 2015
Messages
3,078
Location
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Enhanced said:
Oh I meant it the opposite way. I was worried about Mucuna Pruriens potentially increasing serotonin as an adverse effect, as I'm thinking of supplementing it. I already have first-hand experience with serotonin reuptake inhibitors affecting me very badly.
Click to expand...
I also have first hand experience with serotonin reuptake inhibitors that affected me very badly. I learned that I had a thiamine deficiency. Thiamine is needed to clear serotonin from the brain; if you are low in thiamine, the serotonin cannot clear as it is supposed to. I found great improvement in many health issues from taking high dose thiamine.

pubmed.ncbi.nlm.nih.gov

Effect of thiamine deficiency on brain serotonin turnover - PubMed

Serotonin turnover has been investigated in regional brain areas of rats made thiamine deficient by pyrithiamine (PT). Following intracisternal injection of [14C]5-hydroxytryptamine ([14C]5-HT), a marked increase in the accumulation of [14C]5-hydroxyindoleacetic acid ([14C]5-HIAA) was found in...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
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