Mucuna Pruriens induced crash, need advice

Don Quixote

Member
Joined
Apr 26, 2020
Messages
62
I am pretty sure I crashed from a pre-workout that had mucuna pruriens in it. It also had some other stimulants but I believe the mucuna is the cause of the crash due to the L-Dopa. Right now i am experiencing some severe low symptoms, like depression, anhedonia, insane brain fog/depersonalization, and fatigue. Could be low epinephrine/serotonin as well.

I am thinking my dopamine/serotonin system is messed up now. Perhaps my brain down-regulated the dopamine or the 5-HTP receptors were damaged.

How can I "reset" or normalize my receptors? I read about uridine but am afraid it will cause cancer or fatty liver...
 

magnesiumania

Member
Joined
Jul 17, 2018
Messages
461
Uridine short term is rather safe i think.

Remember tyrosine and tryptophan has benzene rings. They are photon traps and are being programmed by natural light. Go outside to make your neurotransmitters work.

L-dopa can be neurotoxic, i wouldent fool around with it unless you know what youre doing....
 

dukesbobby777

Member
Joined
Sep 22, 2020
Messages
276
What were the other ingredients in the drink? I’ve never heard of mucunã being neurotóxic. It’s a herb that’s been used for centuries without links (AFAIK) to brain damage.

L-dopa, by itself, as an isolated compound, has been linked with neurotoxicity.
 

shine

Member
Joined
Sep 27, 2018
Messages
476
A few days ago I read an article about a doctor who treated Parkinson's patients with gram doses of thiamine/b1. In one part of the article it said that thiamine in high doses protected from the dyskinesias associated with L-dopa treatment.

Uridine increases your dopamine receptor turnover rate. So if you have damaged dopamine receptors, they will be replaced faster by fresh, functioning ones. Taking uridine for 1-2 days can help a lot in my experience. I wouldn't take it chronically though, more like every couple months for a short period.

Also, what pre-workout were you taking? Would be interesting to know what else is in it.
 

Perry Staltic

Member
Joined
Dec 14, 2020
Messages
1,456
L-dopa according to this article is serotonergic (increases serotonin) and can trigger serotonin syndrome.

Perhaps adding to the diagnostic challenge is the fact that a huge number of drugs — prescription, over the counter, recreational and herbal — can trigger the syndrome. In addition to selective serotonin reuptake inhibitors like Zoloft, Prozac and Paxil and serotonin/norepinephrine reuptake inhibitors like Effexor, the list includes tricyclic antidepressants and MAOIs (for monoamine oxidase inhibitors); narcotic painkillers like fentanyl and tramadol; over-the-counter cough and cold remedies containing dextromethorphan; the anticonvulsant valproate; triptans like Imitrex used to treat and prevent migraines; the antibiotic Zyvox (linezolide); antinausea drugs; the anti-Parkinson’s drug L-dopa; the weight-loss drug Meridia (sibutramine); lithium; the dietary supplements tryptophan, St. John’s wort and ginseng; and several drugs of abuse, including ecstasy, LSD, amphetamines, the hallucinogens foxy methoxy and Syrian rue.


 

Don Quixote

Member
Thread starter
Joined
Apr 26, 2020
Messages
62
A few days ago I read an article about a doctor who treated Parkinson's patients with gram doses of thiamine/b1. In one part of the article it said that thiamine in high doses protected from the dyskinesias associated with L-dopa treatment.

Uridine increases your dopamine receptor turnover rate. So if you have damaged dopamine receptors, they will be replaced faster by fresh, functioning ones. Taking uridine for 1-2 days can help a lot in my experience. I wouldn't take it chronically though, more like every couple months for a short period.

Also, what pre-workout were you taking? Would be interesting to know what else is in it.
I'll try to find uridine for a short term, it's quite hard to get unless shipped. What about SAM-e? Was thinking maybe trying that... Here is the ingredients for the pre-workout. I only took it three times but the last time I had a cup of coffee before and then took it on an empty stomach and lifted. I had insane energy from it.

. 1609365535107.png
 

Don Quixote

Member
Thread starter
Joined
Apr 26, 2020
Messages
62
Uridine short term is rather safe i think.

Remember tyrosine and tryptophan has benzene rings. They are photon traps and are being programmed by natural light. Go outside to make your neurotransmitters work.

L-dopa can be neurotoxic, i wouldent fool around with it unless you know what youre doing....
I do not get enough sunlight, no doubt about that... will continue to search for uridine.

I did read L-Dopa is neurotoxic to 5HT1(A) receptors because those receptors are the ones secreting dopamine and they can't handle it. So honestly I am wondering if i caused brain damage. Is there anything that heals/restores or increases turnover of serotonin receptors in the same way that uridine does for dopamine?
 
Last edited:

dukesbobby777

Member
Joined
Sep 22, 2020
Messages
276
L-dopa, if taken by itself, won’t even reach the brain to make dopamine. It will just turn into dopamine in the tissues instead, so you’d get annoying periphery side effects instead (nausea, etc). It needs to be taken with a decarboxylase inhibitor to ensure it gets past the blood brain barrier to make dopamine in the brain.

So if they’ve just used L-dopa in that product it’s likely not had any effect in your brain. If it’s actually the mucunã herb, then you likely don’t have anything to worry about (if you believe that taking the whole herb is protective).

Looking at that list of ingredients you have a long list of stimulating/awakening (and cholinergic) compounds, which more likely explains your negative reaction to the drink.

N-acetyl-tyrosine (from that list) is one supplement that I personally reacted very bad to (wired, edgy, etc).
 
Last edited:

Don Quixote

Member
Thread starter
Joined
Apr 26, 2020
Messages
62
L-dopa, if taken by itself, won’t even reach the brain to make dopamine. It will just turn into dopamine in the tissues instead, so you’d get annoying periphery side effects instead (nausea, etc). It needs to be taken with a decarboxylase inhibitor to ensure it gets past the blood brain barrier to make dopamine in the brain.

So if they’ve just used L-dopa in that product it’s likely not had any effect in your brain. If it’s actually the mucunã herb, then you likely don’t have anything to worry about (if you believe that taking the whole herb is protective).

Looking at that list of ingredients you have a long list of stimulating/awakening (and cholinergic) compounds, which more likely explains your negative reaction to the drink.

N-acetyl-tyrosine (from that list) is one supplement that I personally reacted very bad to (wired, edgy, etc).
Thanks for the input.

If it’s actually the mucunã herb, then you likely don’t have anything to worry about
I read somewhere that mucuna whole herb does reach the brain... but you think that somehow it is non-toxic as a whole herb?

N-acetyl-tyrosine (from that list) is one supplement that I personally reacted very bad to (wired, edgy, etc).
i did get very wired from it for sure, but the withdrawal snap-back effect feels like brain damage or autism, I am fixating on things and am distracted from whatever is going on around me. I can't find correct words, my eyes are staring into space without blinking, my speech is slurred, etc. Possibly this is from something totally different like some iron or copper deficiency which I will test soon but idk why it would come on so suddenly after that pre-workout, it is the only thing that changed in my diet.

I did read as well somewhere that mucuna is an effective iron and copper chelator and chelates divalent atoms, so could also have chelated mercury...who knows.
 
Similar threads
Thread starter Title Forum Replies Date
F Mucuna Pruriens Helps So Much Supplements 10
T Boosting Dopamine While Using Dopamine Antagonist With Mucuna Pruriens Please Help Ask For Help or Advice 18
J Mucuna Pruriens Supplements 7
B Nitric Oxide Linked To PD, Mucuna Pruriens Works Through Reducing It Scientific Studies 1
B Peaters - Opinion On Mucuna Pruriens Supplementation? Supplements 19
Gadreel Safed Musli Vs. Mucuna Supplements, Pharmaceutical Drugs 13
M Zinc induced copper deficiency/ Excess zinc blocks copper absorption for long time Ask For Help or Advice 0
S S-allyl-l-cysteine for mild Ashwagandha induced pssd? Male Issues 2
Mito Carnosine improves aging-induced cognitive impairment Articles & Scientific Studies 0
haidut Sugar (sucrose) lowers stress-induced cortisol Scientific Studies 2
Sam321 Covid Induced Health Issues Ask For Help or Advice 10
Lokzo Systemic inflammation enhances stimulant-induced dopamine levels [2017] Scientific Studies 0
Q Is Vitamin D induced serotonin syndrome possible? Please hear me out... Ask For Help or Advice 60
Mauritio What you can do about quarantine induced social isolation and depression : Allopregnanolone! Scientific Studies 79
Diokine LLLT may treat or prevent COVID-19 induced endothelial dysfunction Red Light, Infrared, LLLT 1
S Low dose aspirin to treat inflamation induced insulin resisitance? Blood Sugar 1
R Verbascoside (from cistanche) reduces hypoxia-induced memory impairment in rat model Scientific Studies 0
R Echinacoside (from cistanche) attenuates ethanol-induced oxidative stress in rat model Scientific Studies 0
R Echinacoside (from cistanche) attenuates kainic acid induced excitotoxicity in rat model Scientific Studies 0
Broken man Taurine prevents tamoxifen-induced mitochondrial oxidative damage in mice Scientific Studies 4
R Bixin carotenoide from annatto bean is anti-inflammatory, reduces carrageenan-induced paw edema in rats Scientific Studies 0
haidut Vitamin D prevents cortisol-induced depression and...inflammation Scientific Studies 0
E Wooshing blurring sounds induced temporary few second hearing loss in the left ear Eyes, Ears, Nose and Headaches/Migraines 5
Lokzo Cyproheptadine Prevents High Altitude-Induced Testicular Disturbances Scientific Studies 0
E Past Left Arm Elbow Area Minifracture Induced Difference In Pressure During Exercising Ask For Help or Advice 0
noqcks Help - Chemotherapy Induced Male Infertility Male Issues 2
K Found A Gem For Starters - Prevention Of Arachidonic Acid‑induced Liver Injury With Garlic Extracts Meet & Greet 5
A Hypothyroidism Is Naturally Induced Chemo Therapy. Every Metabolic Stressor Is A Carcinogenic Miscellaneous Health Discussions 23
Doludolu Neuroprotection By DHT In LPS-induced Neuroinflammation Thyroid and Hormones 2
E β-glucan Attenuates Cognitive Impairment Via The Gut-brain Axis In Diet-induced Obese Mice [10- 2020 Scientific Studies 0
GorillaHead Salt Loading Induced Acute Hyperhidrosis And Cold Hands Why! Ask For Help or Advice 27
LLight Hepatic Injury Induced By Radio Frequency Waves Emitted From Conventional Wi-Fi Devices Scientific Studies 15
ScurveDream DHEA Or Pregnenolone To Combat Possible Caffeine-induced Stress? Ask For Help or Advice 9
Sefton10 Fruit Supplementation Reduces Indices Of Exercise-induced Muscle Damage: A Systematic Review And Met Exercise 0
B Carrageenan Induced Ankle Edema Testimonials 15
Mito Biotin, Coenzyme Q10, And Their Combination Ameliorate Aluminium Chloride-induced Alzheimer's Alzheimer's 2
bzmazu Covid-19 Being Driven By Diet Induced Destruction Viruses, Parasites, Fungus, Vaccines 1
S Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated By Sodium Butyrate Via Inhibitin Scientific Studies 0
G Winter Induced Symptoms Thyroid and Hormones 4
R Gut Microbiota Mediates Intermittent-fasting Alleviation Of Diabetes-induced Cognitive Impairment Scientific Studies 0
M Supplemental Cellulose Ameliorates LPS Induced Intestinal Permeability Scientific Studies 12
Hans Succinic Acid For Metformin Induced Lactic Acidosis Scientific Studies 19
Mito Are Lipid Peroxidation Processes Induced By Changes In The Cell Wall Structure Scientific Studies 0
meatbag DHEA Inhibits The Activation And Dysfunction Of Endothelial Cells Induced By High Scientific Studies 0
K Taurine-induced Prolactin Secretion? Amino Acids 8
GutFeeling Severe Serotonin Syndrome Induced By Mirtazapine Monotherapy Scientific Studies 1
allblues Stress-induced Anhedonia Correlated With Lower Serotonin Transporter Expression Scientific Studies 0
LucyL DCA The Solution To Metformin Induced Lactate? Cancer 3
jzeno Branched-chain Amino Acid Plus Glucose Supplement Reduces Exercise-induced Delayed Onset Muscle Sore Scientific Studies 0
L Caffeine Protects Dopaminergic Neurons From Dopamine-Induced Neurodegeneration Via Synergistic Adeno Scientific Studies 2

Similar threads

Top