I have limited access to some AI technology that has the ability to read and analyse thousands of studies within seconds and give me a response based on what it has learnt. I'm not an expert in biology or anything and I'm mainly here to learn how I can help treat my dog with transitional cell carcinoma through diet and re-purposed drugs like fenbendazole and cyproheptadine etc.
Anyway, I hear that Gelatine was something I should add to my dogs diet due to it having the ability to offer some protection to the liver and kidneys as well as offering some protection to the stomach lining from NSAIDs like Meloxicam or Aspirin for example. So I decided to ask the AI about the metabolic pathways of TCC and it came back with this...
''Transitional cell carcinoma, like other types of cancer, is characterized by metabolic reprogramming [1], including increased glycolysis, glutaminolysis, lipid metabolism, and the pentose phosphate pathway [2]. Additionally, research has shown that the hexosamine biosynthetic pathway (HBP) is altered in cancer cells and is heavily reliant on nutrients [3]. This pathway is important for cell signaling, and altered nutrient uptake is a hallmark of cancer. It is believed that the HBP plays a role in the development and progression of Transitional cell carcinoma.''
I have very basic understanding of what it's on about so I then ask the AI what nutrients does HBP rely on and can fenbendazole block the hexosamine biosynthetic pathway? (since I'm giving my dog fenbendazole I thought I'd see how and if it can help) and it said this...
''The hexosamine biosynthetic pathway (HBP) relies on a variety of nutrients and substrates for its activity, including glucose, glutamine, and glycine. Additionally, recent studies suggest that folate, fat, and sulfur-containing amino acids (methionine and cysteine) are important for HBP activity [4]. Fenbendazole has also been reported to block the activity of the hexosamine biosynthetic pathway by inhibiting the activity of key enzymes involved in the pathway, such as glutamine:fructose-6-phosphate amidotransferase (GFAT) [5]. Fenbendazole works by binding to the active site of the enzyme, preventing it from catalyzing the reaction. In addition, fenbendazole has been reported to inhibit the activity of other enzymes involved in HBP, such as xylulose-5-phosphate phosphoketolase, ketoglutarate dehydrogenase, and glucosamine-6-phosphate synthase, further blocking the pathway and resulting in reduced glucose uptake in cancer cells [6].''
So the HBP pathway is an important pathway in transitional cell carcinoma and one of the main fuel sources it mentions is glycine which is mentioned a lot of this forum for a number of different benefits including it's anti cancer properties. So I ask it about what to avoid with regards to the diet etc with this type of cancer and it said this...
''Transitional cell carcinoma needs specific nutrients in order to facilitate its growth and survival. Specifically, TCC needs glucose, glutamine, and glycine for its metabolic reprogramming [1]. Additionally, folate, fat, and sulfur-containing amino acids such as methionine and cysteine are important for the activity of the hexosamine biosynthetic pathway, which is believed to play a role in the development and progression of TCC [2].
When it comes to reversing the cancer cells into healthy cells, the best course of action is to avoid the nutrients that fuel cancer cell growth. This includes glucose, glutamine, and glycine, as well as folate, fat, and sulfur-containing amino acids. Additionally, it is important to focus on consuming a healthy and balanced diet that is rich in antioxidants and other essential nutrients to support optimal health.''
I then asked it specifically about glycine and TCC and it said this...
''Glycine has been suggested as a potential method of preventing and treating cancer, as it has been shown to inhibit the activity of the vascular endothelial growth factor (VEGF), which is a key driver of tumor growth. Additionally, glycine has been found to oppose the effects of pro-inflammatory polyunsaturated fatty acids (PUFAs) and estrogen, two compounds that are central to tumor progression.
However, glycine is also believed to be beneficial for the growth of transitional cell carcinoma (TCC). Glycine is an important component of the hexosamine biosynthetic pathway, which is involved in TCC metabolism and is heavily reliant on glycine for its activity. Additionally, glycine has been found to help increase the uptake of glucose in TCC cells, which is essential for their growth and survival. Finally, glycine has also been found to reduce the pro-inflammatory effects of lipopolysaccharide (LPS) in TCC cells, further promoting their survival and growth.
Furthermore, one of the main effects of glycine is the depletion of glutamine, as well as the lowering of excessive glycolysis. This can have a positive impact on TCC cell metabolism, as glycine helps reduce high levels of glucose metabolism that can lead to oxidative stress and impaired cell cycle progression. Additionally, the depletion of glutamine can also help to reduce the levels of inflammation associated with TCC, which can further reduce tumor growth. Ultimately, these studies demonstrate the potential of glycine to support the growth of TCC cells, while also potentially reducing the growth of malignant tumors.''
I decided to throw in a copy of Ray Peats email response to glycine and cancer and this is how it responded...
''The studies referenced in the question provide evidence that glycine may be beneficial for the growth of transitional cell carcinoma (TCC). Glycine is an important component of the hexosamine biosynthetic pathway, which is involved in TCC metabolism and is heavily reliant on glycine for its activity. Additionally, glycine has been found to help increase the uptake of glucose, a key nutrient for TCC cell survival and growth. Furthermore, glycine has also been found to reduce the pro-inflammatory effects of lipopolysaccharide (LPS), further promoting TCC cell survival and growth.
The question also raises the importance of considering the organism and the liver in regards to glycine’s potential benefits for TCC. Glycine is a glucogenic amino acid, meaning it can be used by the body as an energy source. Additionally, glycine has been found to activate the enzyme phosphofructokinase (PFKFB4), which is involved in the glycolysis process and is normally increased by oxygen deprivation and the hypoxia inducible factor (HIF). Furthermore, glycine has also been found to reduce the levels of inflammation associated with TCC, which can further reduce tumor growth. Finally, glycine can help to reduce high levels of glucose metabolism, which can lead to oxidative stress and impaired cell cycle progression.
In summary, the studies referenced in the question provide evidence that glycine can be beneficial for the growth of TCC, due to its role in promoting glucose uptake, reducing inflammation, and reducing excessive glucose metabolism. Additionally, glycine can also help to activate PFKFB4, a key enzyme involved in the glycolysis process, and reduce the levels of inflammation associated with TCC.''
What do you guys think to these responses, is the AI way off or is glycine actually useful when it comes to cancer?
Anyway, I hear that Gelatine was something I should add to my dogs diet due to it having the ability to offer some protection to the liver and kidneys as well as offering some protection to the stomach lining from NSAIDs like Meloxicam or Aspirin for example. So I decided to ask the AI about the metabolic pathways of TCC and it came back with this...
''Transitional cell carcinoma, like other types of cancer, is characterized by metabolic reprogramming [1], including increased glycolysis, glutaminolysis, lipid metabolism, and the pentose phosphate pathway [2]. Additionally, research has shown that the hexosamine biosynthetic pathway (HBP) is altered in cancer cells and is heavily reliant on nutrients [3]. This pathway is important for cell signaling, and altered nutrient uptake is a hallmark of cancer. It is believed that the HBP plays a role in the development and progression of Transitional cell carcinoma.''
I have very basic understanding of what it's on about so I then ask the AI what nutrients does HBP rely on and can fenbendazole block the hexosamine biosynthetic pathway? (since I'm giving my dog fenbendazole I thought I'd see how and if it can help) and it said this...
''The hexosamine biosynthetic pathway (HBP) relies on a variety of nutrients and substrates for its activity, including glucose, glutamine, and glycine. Additionally, recent studies suggest that folate, fat, and sulfur-containing amino acids (methionine and cysteine) are important for HBP activity [4]. Fenbendazole has also been reported to block the activity of the hexosamine biosynthetic pathway by inhibiting the activity of key enzymes involved in the pathway, such as glutamine:fructose-6-phosphate amidotransferase (GFAT) [5]. Fenbendazole works by binding to the active site of the enzyme, preventing it from catalyzing the reaction. In addition, fenbendazole has been reported to inhibit the activity of other enzymes involved in HBP, such as xylulose-5-phosphate phosphoketolase, ketoglutarate dehydrogenase, and glucosamine-6-phosphate synthase, further blocking the pathway and resulting in reduced glucose uptake in cancer cells [6].''
So the HBP pathway is an important pathway in transitional cell carcinoma and one of the main fuel sources it mentions is glycine which is mentioned a lot of this forum for a number of different benefits including it's anti cancer properties. So I ask it about what to avoid with regards to the diet etc with this type of cancer and it said this...
''Transitional cell carcinoma needs specific nutrients in order to facilitate its growth and survival. Specifically, TCC needs glucose, glutamine, and glycine for its metabolic reprogramming [1]. Additionally, folate, fat, and sulfur-containing amino acids such as methionine and cysteine are important for the activity of the hexosamine biosynthetic pathway, which is believed to play a role in the development and progression of TCC [2].
When it comes to reversing the cancer cells into healthy cells, the best course of action is to avoid the nutrients that fuel cancer cell growth. This includes glucose, glutamine, and glycine, as well as folate, fat, and sulfur-containing amino acids. Additionally, it is important to focus on consuming a healthy and balanced diet that is rich in antioxidants and other essential nutrients to support optimal health.''
I then asked it specifically about glycine and TCC and it said this...
''Glycine has been suggested as a potential method of preventing and treating cancer, as it has been shown to inhibit the activity of the vascular endothelial growth factor (VEGF), which is a key driver of tumor growth. Additionally, glycine has been found to oppose the effects of pro-inflammatory polyunsaturated fatty acids (PUFAs) and estrogen, two compounds that are central to tumor progression.
However, glycine is also believed to be beneficial for the growth of transitional cell carcinoma (TCC). Glycine is an important component of the hexosamine biosynthetic pathway, which is involved in TCC metabolism and is heavily reliant on glycine for its activity. Additionally, glycine has been found to help increase the uptake of glucose in TCC cells, which is essential for their growth and survival. Finally, glycine has also been found to reduce the pro-inflammatory effects of lipopolysaccharide (LPS) in TCC cells, further promoting their survival and growth.
Furthermore, one of the main effects of glycine is the depletion of glutamine, as well as the lowering of excessive glycolysis. This can have a positive impact on TCC cell metabolism, as glycine helps reduce high levels of glucose metabolism that can lead to oxidative stress and impaired cell cycle progression. Additionally, the depletion of glutamine can also help to reduce the levels of inflammation associated with TCC, which can further reduce tumor growth. Ultimately, these studies demonstrate the potential of glycine to support the growth of TCC cells, while also potentially reducing the growth of malignant tumors.''
I decided to throw in a copy of Ray Peats email response to glycine and cancer and this is how it responded...
''The studies referenced in the question provide evidence that glycine may be beneficial for the growth of transitional cell carcinoma (TCC). Glycine is an important component of the hexosamine biosynthetic pathway, which is involved in TCC metabolism and is heavily reliant on glycine for its activity. Additionally, glycine has been found to help increase the uptake of glucose, a key nutrient for TCC cell survival and growth. Furthermore, glycine has also been found to reduce the pro-inflammatory effects of lipopolysaccharide (LPS), further promoting TCC cell survival and growth.
The question also raises the importance of considering the organism and the liver in regards to glycine’s potential benefits for TCC. Glycine is a glucogenic amino acid, meaning it can be used by the body as an energy source. Additionally, glycine has been found to activate the enzyme phosphofructokinase (PFKFB4), which is involved in the glycolysis process and is normally increased by oxygen deprivation and the hypoxia inducible factor (HIF). Furthermore, glycine has also been found to reduce the levels of inflammation associated with TCC, which can further reduce tumor growth. Finally, glycine can help to reduce high levels of glucose metabolism, which can lead to oxidative stress and impaired cell cycle progression.
In summary, the studies referenced in the question provide evidence that glycine can be beneficial for the growth of TCC, due to its role in promoting glucose uptake, reducing inflammation, and reducing excessive glucose metabolism. Additionally, glycine can also help to activate PFKFB4, a key enzyme involved in the glycolysis process, and reduce the levels of inflammation associated with TCC.''
What do you guys think to these responses, is the AI way off or is glycine actually useful when it comes to cancer?