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  1. A

    If estrogen is a paracrine hormone, how do we lower it?

    I know that Aromatase Inhibitors (AI) lower estrogen in serum, but how do we lower the overall estrogenic activity if estrogen is a paracrine hormone?
  2. Gûs80

    Could aromatase inhibitors be useful in autoimmune diseases?

    Dr Ray Peat mentions in some articles that the cause of autoimmune diseases is high estrogen. Considering this, has anyone seen benefits from using a pharmaceutical aromatase inhibitor? I have a positive ANA marker for Lupus/Sjogren's, and even though it's low, I have several of the symptoms of...
  3. A

    Dual use of artificial-intelligence-powered drug discovery

    https://www.science.org/content/blog-post/deliberately-optimizing-harm This new paper is worrying but not surprising. It describes a recent effort to (mis)use computational drug design software (especially as applied to avoid compounds with predicted toxicity), flipping the signs to have the...
  4. Drareg

    Analog computers making a comeback?

    Many of you will already know Peats thoughts on analog, its closer to how we function as humans than digital, it turns out big tech are starting to realise this now, AI works better with analog, this video is worth your time, this guys channel isn't bad, he's a bit "mainstreamy". I think in the...
  5. P

    Estrogen and SERMs - Post SERM Syndrome?

    Could the SERMs I took two years ago after taking steroids permanently crash my E2? I simultaneously have high and very low E2 symptoms combined after I took Nolvadex in a PCT. Testicles hang very high and gyno is as puffy as ever and half-working penis for a few years now. When I started...
  6. haidut

    The Fed - The Old Economy, As We Know It, Is Probably Gone

    If there was any doubt left that we are indeed in the middle of an unprecedented social and economic experiment/shift, and nothing about this pandemic is random or even natural - here are the comments from the Fed Chairman. They sound as if he just got off the phone with Mr. Klaus from the WEF...