GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life

[Mito]

Abstract​

Determinants of length of life are not well understood, and therefore increasing lifespan is a challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial dysfunction contribute to the aging process, but it is unclear if they could also impact lifespan. Glutathione (GSH), the most abundant intracellular antioxidant, protects cells from OxS and is necessary for maintaining mitochondrial health, but GSH levels decline with aging. Based on published human studies where we found that supplementing glycine and N-acetylcysteine (GlyNAC) improved/corrected GSH deficiency, OxS and mitochondrial dysfunction, we hypothesized that GlyNAC supplementation could increase longevity. We tested our hypothesis by evaluating the effect of supplementing GlyNAC vs. placebo in C57BL/6J mice on (a) length of life; and (b) age-associated GSH deficiency, OxS, mitochondrial dysfunction, abnormal mitophagy and nutrient-sensing, and genomic-damage in the heart, liver and kidneys. Results showed that mice receiving GlyNAC supplementation (1) lived 24% longer than control mice; (2) improved/corrected impaired GSH synthesis, GSH deficiency, OxS, mitochondrial dysfunction, abnormal mitophagy and nutrient-sensing, and genomic-damage. These studies provide proof-of-concept that GlyNAC supplementation can increase lifespan and improve multiple age-associated defects. GlyNAC could be a novel and simple nutritional supplement to improve lifespan and healthspan, and warrants additional investigation.

Conclusions
The results of these rodent studies indicate that supplementing GlyNAC increases length of life. GlyNAC supplementation also corrects GSH deficiency, OxS, and multiple aging hallmarks (mitochondrial dysfunction, abnormalities in mitophagy and nutrient sensing, and genomic damage) in vital organs such as the heart, liver and kidneys. GlyNAC supplementation could have important implications for promoting healthy aging and improving both healthspan and lifespan in humans.

https://mdpi-res.com/d_attachment/nutrients/nutrients-14-01114/article_deploy/nutrients-14-01114.pdf?version=1646633366

 

[Mito]

View: https://www.youtube.com/watch?v=i_w_DYKvlBM

 

[frannybananny]

View: https://www.youtube.com/watch?v=i_w_DYKvlBM

Interesting !Thanks! But those high dosages are a little frightening. Do you supplement with glycine and NAC? What dosages do you take?

 

[area51puy]

Is GlyNAC something they created by bonding glycine and nac or did the just give them the two supplements. And does it matter either way?

 

[Mito]

Is GlyNAC something they created by bonding glycine and nac or did the just give them the two supplements. And does it matter either way?

I think two separate supplements.

Do you supplement with glycine and NAC?

No