Spermidine, Found In Cheese And Semen, Extends Lifespan Of Mice And May Work For Humans


Jan 6, 2015


Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.


Aug 2, 2017
Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions.
Ramot Y , et al.

Rapidly regenerating tissues need sufficient polyamine synthesis. Since the hair follicle (HF) is a highly proliferative mini-organ, polyamines may also be important for normal hair growth. However, the role of polyamines in human HF biology and their effect on HF epithelial stem cells in situ remains largely unknown.

We have studied the effects of the prototypic polyamine, spermidine (0.1-1 µM), on human scalp HFs and human HF epithelial stem cells in serum-free organ culture. Under these conditions, spermidine promoted hair shaft elongation and prolonged hair growth (anagen). Spermidine also upregulated expression of the epithelial stem cell-associated keratins K15 and K19, and dose-dependently modulated K15 promoter activity in situ and the colony forming efficiency, proliferation and K15 expression of isolated human K15-GFP+ cells in vitro. Inhibiting the rate-limiting enzyme of polyamine synthesis, ornithine decarboyxlase (ODC), downregulated intrafollicular K15 expression. In primary human epidermal keratinocytes, spermidine slightly promoted entry into the S/G2-M phases of the cell cycle. By microarray analysis of human HF mRNA extracts, spermidine upregulated several key target genes implicated e.g. in the control of cell adherence and migration (POP3), or endoplasmic reticulum and mitochondrial functions (SYVN1, NACA and SLC25A3). Excess spermidine may restrict further intrafollicular polyamine synthesis by inhibiting ODC gene and protein expression in the HF's companion layer in situ.

These physiologically and clinically relevant data provide the first direct evidence that spermidine is a potent stimulator of human hair growth and a previously unknown modulator of human epithelial stem cell biology.


Sep 19, 2016
Great. Ill let my girlfriend know.


Jan 26, 2021
I use it for about 2 months, powder form (Raab vitalfood, from wheat germ). Taste is quite...disgusting, I mix it with about 8-9g glycine and 4g taurine pre-bed with a big glass of water +lemon juice.
No noticeable effects, but it's for the long term.
I eat also lots of raw cheese each day (french here, my weakness with dark chocolate), so my total daily spermidine income should be quite high...
Similar threads
Thread starter Title Forum Replies Date
meatbag Venus flytraps found to produce magnetic fields Scientific Studies 0
J I think i've found the best dental filling product Oral Health 8
J Found the best non toxic mattresses in the UK Insomnia, Sleep Issues 1
Hugh Johnson French professor who found links between the Pasteur institute and covid19 forced into a mental asylum. Society 4
H R.I.P ex-Merck rep Brandy Vaughn found dead Viruses, Parasites, Fungus, Vaccines 9
A i've found an online seller of thyroid Synthetic Thyroid 19
joshquintanilla Found A Way To Block ALL Blue Light On IPhone Easily Light 36
K Found A Gem For Starters - Prevention Of Arachidonic Acid‑induced Liver Injury With Garlic Extracts Meet & Greet 5
S What Have You Found Most Helpful For Your Libido And Sexual Function? Ask For Help or Advice 102
S Found The Safest Soap To Use During Shower Body Care 33
Dino D Covid Cure Found In Bosnien Breaking News 1
mayweatherking Pathologist Found Blood Clots In ‘almost Every Organ’ During Autopsies On COVID-19 Patients Viruses, Parasites, Fungus, Vaccines 46
S Think I've Found The Cause Of My Premature Ejaculation! Male Issues 35
S Think I May Have Found The Cause Of My Erectile Dysfunction/potentially My Premature Ejaculation Male Issues 23
Jake sullivan Iron Bits Found In Refined Sugar? Sugar, Honey 12
jzeno I Finally Found A Food That STRENGTHENS Nails! FRESH PLUM JUICE! Experiments 3
haidut Emulsifiers Found In Most Commercial Foods Cause Brain Tumors, Hemorrhage, And Stroke Scientific Studies 2
B You Have No Idea How Glad I Am To Have Found This Forum K 10
Xisca Oxalate Found In Thyroid In 79% Of Adults Thyroid and Hormones 6
L This Coq10 Supplement I Found In The Mainstream Supermarket Has Coconut Oil In It Supplements, Pharmaceutical Drugs 1
C Has Anyone Found Anything That Regrows Hair? Hair & Nails 21
ScurveDream Is This Mold? Found This Right Above My Bed! Ask For Help or Advice 7
A The Most Androgenic Herbs That I Have Found Supplements, Pharmaceutical Drugs 48
C I Found The Cheap MK-4. Is It Reliable? Vitamins 1
RobertJM A New Peat Inspired Blog Found Blogs 0
johnwester130 Found Marmalade Without Pectin In The UK Beverages, Fruits, Sugars 8
T Salvestrols, Nutrients Missing In Our Food, Activate Enzyme Found Only In Cancer Cells For Apoptosis Cancer 10
Beefcake Man Spent 35 Years Studying The Brains Of Serial Killers. Found Increased Serotonin Scientific Studies 34
meatbag PFAS Forever Chemicals Found In Food Supply By FDA Breaking News 8
ecstatichamster Molecular Biology What We Know And How We Found It Book Recommendations 1
D Lower Ceruloplasmin Found In Parkinson’s Scientific Studies 44
W After Much Research, I Have Finally Found A Way To Get Very Low PUFA Goat Milk Milk 71
cyclops Found This Clip Of Peat When Considering A New Supplement Supplements, Pharmaceutical Drugs 0
charlie A Statistically Strong Relationship Has Been Found Between The MMR Vaccine & Autism Vaccines 2
D Study Found Positive Correlation Between Iron And Total +free Testosterone, Higher T3, DHT Scientific Studies 17
T Glyphosate Found In All 5 Major Orange Juice Brands Fruit Juice 56
Hugh Johnson Microplastics Found In 90 Percent Of Table Salt Health 29
debored13 Protein Found Conducting Electricity For The First Time Articles & Scientific Studies 2
T Consuming High-fat Dairy Products Found To Make Lung Function In Smokers Even Worse Scientific Studies 1
T Unusually High Levels Of Herpesviruses Found In The Alzheimer’s Disease Brain Scientific Studies 0
D Possible Link Found Between Diabetes And Titanium Dioxide Scientific Studies 3
Badger Type Of Sugar Often Found In Ice Cream Leads To Deadly Gut Infection Ice Cream 16
H Found The Root Cause Of My Hairloss And Now Im Pissed Hair & Nails 27
Mito Scientists Think They Found A New Human Organ—a Fluid-filled “shock Absorber” Miscellaneous Health Discussions 0
D Where Is Good Reliable Glycine To Be Found ? Supplements, Pharmaceutical Drugs 9
Brian fitusi Found Pleny Of Info On This, No Need To Respond. Diet 0
haidut US Government Study Found Cellphones (EMF) Cause Brain And Heart Cancer Scientific Studies 0
pimpnamedraypeat Human Footprints Found In 5.7 Million Year Old Rock Political Talk, Alternative World Theories 2
haidut Alien Life May Have Been Found On The International Space Station (ISS) Scientific Studies 18
A Has Anyone Found A Decent (talk) Therapist? Stress 13

Similar threads