Endogenous fructose production and metabolism in the liver c

[Edward]

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

Carbohydrates with high glycaemic index are proposed to promote the development of obesity, insulin resistance and fatty liver, but the mechanism by which this occurs remains unknown. High serum glucose concentrations are known to induce the polyol pathway and increase fructose generation in the liver. Here we show that this hepatic, endogenously produced fructose causes systemic metabolic changes. We demonstrate that mice unable to metabolize fructose are protected from an increase in energy intake and body weight, visceral obesity, fatty liver, elevated insulin levels and hyperleptinaemia after exposure to 10% glucose for 14 weeks. In normal mice, glucose consumption is accompanied by aldose reductase and polyol pathway activation in steatotic areas. In this regard, we show that aldose reductase-deficient mice are protected against glucose-induced fatty liver. We conclude that endogenous fructose generation and metabolism in the liver represents an important mechanism by which glucose promotes the development of metabolic syndrome.

Lanaspa, M. A., Ishimoto, T., Li, N., Cicerchi, C., Orlicky, D. J., Ruzicky, P., … Johnson, R. J. (2013). Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nature communications, 4, 2434. doi:10.1038/ncomms3434

 

[GorillaHead]

Bump. I would like to understand if there are ways we can reduce our aldose reductase

 

[Motorneuron]

@Hans

 

[Hans]

The way we control out fructose production is by controlling our blood sugar. The problem is high blood sugar (insulin resistance), not fructose production.

 

[Andy316]

Is the polyol pathway a genetic issue? If this is the case any glucose source can convert to fructose eventually. I read on this forum somewhere that fructose antagonizes copper. So could people on this polyol pathway be copper deficient forever?

 

[Roni123@]

The way we control out fructose production is by controlling our blood sugar. The problem is high blood sugar (insulin resistance), not fructose production.

hey Hans, in your opinion low fat ( <50 grams) and high carb are good to improve insulin sensivity? but its take a months?

 

[Hans]

hey Hans, in your opinion low fat ( <50 grams) and high carb are good to improve insulin sensivity? but its take a months?

Not overeating and getting all your micros are a really good place to start.