Dairy Fat May Protect Against Type II Diabetes

Discussion in 'Scientific Studies' started by DaveFoster, Jun 17, 2019.

  1. DaveFoster

    DaveFoster Member

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    "BACKGROUND:
    We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15:0 and 17:0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D).

    METHODS AND FINDINGS:
    Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, triglycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men (pinteraction < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist.

    CONCLUSIONS:
    In a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D."

    Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies. - PubMed - NCBI
     
  2. ecstatichamster

    ecstatichamster Member

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  3. OP
    DaveFoster

    DaveFoster Member

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    You're welcome!
     
  4. rei

    rei Member

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    This fits in well with the previous correlational data of skim-milk drinkers dying prematurely compared to whole milk drinkers.
     
  5. yerrag

    yerrag Member

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    Didn't know dairy fat has odd-chained sfas. What was that said about even-chained being better than odd-chained sfas?

    Good to know dairy fat is good. I prefer whole milk over low-fat or skim. Now that it's also long life milk, even better!
     
  6. Birdie

    Birdie Member

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    When I was a kid, about 12, the doctor put me on skim milk for allergies. I guess it helped with that.
    But, by the time I was 16 and reading Adele Davis, I insisted on raw milk. So, I got the fat in it from then on.

    Now, I drink 1% which is what I think RP drinks. He says he likes cheese and ice cream, so just uses 1% milk.
    That made sense to me since I eat cheese and a lot of ice cream these days.
     
  7. Birdie

    Birdie Member

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    "Long life milk." !!
     
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