Relation Of Total Sugars, Fructose And Sucrose With Incident Type 2 Diabetes

[Mito]

BACKGROUND: Sugar-sweetened beverages are associated with type 2 diabetes. To assess whether this association holds for the fructose-containing sugars they contain, we conducted a systematic review and meta-analysis of prospective cohort studies.

INTERPRETATION: Current evidence does not allow us to conclude that fructose-containing sugars independent of food form are associated with increased risk of type 2 diabetes. Further research is likely to affect our estimates.

Relation of total sugars, fructose and sucrose with incident type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies

 

[Wagner83]

Fat-enriched rather than high-fructose diets promote whitening of adipose tissue in a sex-dependent manner. - PubMed - NCBI


J Nutr Biochem. 2017 Nov;49:22-29. doi: 10.1016/j.jnutbio.2017.07.009. Epub 2017 Jul 24.
Fat-enriched rather than high-fructose diets promote whitening of adipose tissue in a sex-dependent manner.
Dobner J1, Ress C2, Rufinatscha K1, Salzmann K2, Salvenmoser W3, Folie S1, Wieser V4, Moser P5, Weiss G6, Goebel G7, Tilg H4, Kaser S8.
Author information
Abstract
Adipose tissue is a critical regulator of energy metabolism and an effector organ of excessive caloric intake. We studied the effects of high-fructose (HFruD), high-fat (HFD) and mixed high-sucrose and high-fat diet (HFHSD) on adipocyte morphology and biology and consecutive metabolic effects in male and female C57BL/6 mice. Forty male and 40 female mice were randomly assigned to one of four dietary groups and fed for 10 weeks ad libitum. After 10 weeks of feeding, mice were analyzed in regard to glucose metabolism, insulin sensitivity and alteration in adipocyte morphology and function. Weight gain and diminished insulin sensitivity in HFD- and HFHSD-fed mice were accompanied by increased adipocyte size and a shift in size distribution towards larger adipocytes in all mice. The latter effect was also found but less pronounced in HFruD-fed mice, while insulin sensitivity and body weight remained unaffected. In male mice, expansion of white adipocytes along with decreased uncoupling protein 1 (UCP-1) expression and alterations of mitochondrial biogenesis was found after HFD and HFHSD feeding, while in female mice, UCP-1 expression was also reduced in the HFruD dietary group. Diet-induced cellular alterations were less pronounced in female mice. Our data demonstrate that high-fat rather than high fructose consumption drives metabolically disadvantageous alterations of adipocyte differentiation involving whitening and insulin resistance in a sex-dependent manner with most deleterious effects seen upon administration of combined sucrose and fat-enriched diet in male mice.

 

[vulture]

What would be the effects of more white fat stored vs brown fat?
I remember that when animals feed more "wildly" in a farm (using no industrial foods in them) their fat looked more brown-yellow, and also seemed to dissolve easier, while animals fed on industrial products tend to have a white fat, and there was no way to make a good oil out of them (porn skin + fat was heat and oil was stored, white fat oil tends to be thicker and disgusting to cook with)