This study is quite timely given the other recent one showing that stopping brain inflammation reverses aging in the brain.
viewtopic.php?f=155&t=8269
Both of the studies are also important because they highlight the primary role PUFA play in both processes. Both studies looked at the effects of antagonizing the leukotrienes - inflammatory mediators derived from arachidonic acid (omega-6 PUFA).
This study showed that inhibiting 5-LOX, an enzyme which synthesizes the leukotrienes, blocks the progression/spreading of cancer. Well known 5-LOX inhibitors in Peat-world include minocycline, vitamin E, caffeic acid, and curcumin. Less known ones are meclofenamate, and zileuton. Leukotriene antagonists include montelukast, zafirlukast and of course cyproheptadine.
http://www.nature.com/nature/journal/va ... 16140.html
http://www.cancerresearchuk.org/about-u ... cer-spread
"...Researchers found that chemical messengers - made by immune cells called neutrophils - can help spreading cancer cells to grow in a new environment. When the scientists looked at breast cancer in mice, they found that these messengers – known as leukotrienes – helped the disease to spread to the lungs."
"...The messengers helped make the lungs more welcoming to cancer by homing in on cancer cells with the highest potential to form a secondary tumour and helping them to multiply. The research showed that using an inhibitor drug** to block these messengers from being produced reduced cancer spread in mice."
viewtopic.php?f=155&t=8269
Both of the studies are also important because they highlight the primary role PUFA play in both processes. Both studies looked at the effects of antagonizing the leukotrienes - inflammatory mediators derived from arachidonic acid (omega-6 PUFA).
This study showed that inhibiting 5-LOX, an enzyme which synthesizes the leukotrienes, blocks the progression/spreading of cancer. Well known 5-LOX inhibitors in Peat-world include minocycline, vitamin E, caffeic acid, and curcumin. Less known ones are meclofenamate, and zileuton. Leukotriene antagonists include montelukast, zafirlukast and of course cyproheptadine.
http://www.nature.com/nature/journal/va ... 16140.html
http://www.cancerresearchuk.org/about-u ... cer-spread
"...Researchers found that chemical messengers - made by immune cells called neutrophils - can help spreading cancer cells to grow in a new environment. When the scientists looked at breast cancer in mice, they found that these messengers – known as leukotrienes – helped the disease to spread to the lungs."
"...The messengers helped make the lungs more welcoming to cancer by homing in on cancer cells with the highest potential to form a secondary tumour and helping them to multiply. The research showed that using an inhibitor drug** to block these messengers from being produced reduced cancer spread in mice."