randle cycle

The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the...

Hi, So this style of eating, helped me go from a cold insomniac. To warm and able to sleep. But then eventually to something like a completely overactive nervous system. And it's kind of like it caused me to burn through all my energy and reserves. Theres metabolism types called fast and...

Just a quick post on a study that provides insight as to how increased fatty acid oxidation (FAO) can "paradoxically" result in increased FAS as well, thus leading to a vicious cycle most commonly seen in diabetes and cancer. One of my recent posts discussed a much more recent study that...

The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an "effect" is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg "Effect" term was coined, the evidence rapidly...

Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...

Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS - i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology...

The study below directly contradicts a mantra commonly repeated in nutrition circles - restrict glucose and increase fat oxidation in order to lose body fat. In fact, this idea is so ingrained into the minds of most people that I often get hate mail from people all over the world angrily...

This is great human study that addresses two key questions people have often asked Peat in regards to SFA vs. PUFA. As Peat has mentioned several times, during stress (exercise in this case) PUFA is preferentially oxidized while SFA is stored. The preferential oxidization of PUFA during stress...

I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...

Natalie Zimmerman of McCarbthyism: "A channel devoted to promoting a scientific understanding of carbohydrates and their essential role in the human diet. We don't practice McCarbthyism, the irrational fear mongering that views our natural desire to eat carbohydrates as the primary reason for...

This is the original study that postulated the existence of the Randle Cycle. I strongly recommend that everyone reads it as it will likely dispell whatever doubts you may have had about Peat and his ideas. I have posted many other studies that directly support the role of the Randle Cycle in...

This was a human study and it directly confirms Peat's views on what causes insulin resistance - elevated fatty acids, through the Randle effect, block oxidation of sugar. It would have been really helpful if the study looked at what happened after restoration of "normal" diet - i.e. how long...