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randle cycle

  1. haidut

    Alzheimer's patients have lower metabolic rate and higher fatty acid oxidation

    Just a quick post in regards to a study that found the drug donepezil - commonly used to "treat" Alzheimer's Disease (AD) - may improve mitochondrial function in muscles. While the findings of the study in regards to donepezil are debatable and not particularly interesting, buried inside the...
    • haidut
    • Thread
    • alzheimer alzheimer disease fatty acid oxidation metabolic rate metabolism randle cycle rer
    • Replies: 1
    • Forum: Scientific Studies
  2. A

    When should I eat my fat,

    I have heard information about the negative effects of free fatty acids and also mixing carbs and fats causing insulin resistance via the randle cycle. My fat intake is 76 grams and my carb intake 450 grams. I normally have a big breakfast consisting of carbs fat and protein altogether with...
    • AndrogenicJB
    • Thread
    • diet free fatty acids randle cycle
    • Replies: 10
    • Forum: Diet
  3. haidut

    Lipolysis / FFA Drive Breast Cancer By Promoting Estrogen Signalling

    The evidence for the fat-loving nature of cancer just keeps on accumulating. During the last podcast with Danny and Ray, I mentioned that in cancer cells the enzyme fatty acid synthase (FAS) is actually part of the estrogen receptor (ER) complex. As such, anything that increases the...
    • haidut
    • Thread
    • breast cancer estrogen fao fatty acid oxidation ffa lipolysis nefa randle cycle
    • Replies: 0
    • Forum: Scientific Studies
  4. L

    Anti-Peat I Think Eating A Ray Peat Style Diet Messed Me Up

    Hi, So this style of eating, helped me go from a cold insomniac. To warm and able to sleep. But then eventually to something like a completely overactive nervous system. And it's kind of like it caused me to burn through all my energy and reserves. Theres metabolism types called fast and...
  5. haidut

    Increased Fatty Acid Synthesis (FAS) Is Simply A Sign Of Oxygen Deficiency / Low Metabolism

    Just a quick post on a study that provides insight as to how increased fatty acid oxidation (FAO) can "paradoxically" result in increased FAS as well, thus leading to a vicious cycle most commonly seen in diabetes and cancer. One of my recent posts discussed a much more recent study that...
    • haidut
    • Thread
    • cancer diabetes electron flow fao fas fasn nad nadh oxidation oxphos oxygen randle cycle terminal electron acceptor
    • Replies: 3
    • Forum: Scientific Studies
  6. haidut

    Acidosis (Warburg Effect) Drives Cancer Through Increased Fat Oxidation (Randle Cycle)

    The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an "effect" is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg "Effect" term was coined, the evidence rapidly...
    • haidut
    • Thread
    • acidosis aspirin cancer cause drive fao fas fasn lactate metabolic disease niacinamide randle cycle sirt sirt1 sirt6 warburg effect warburg-randle warburg-randle cycle
    • Replies: 7
    • Forum: Scientific Studies
  7. haidut

    Inhibiting Fatty Acid Synthesis (FAS) Dramatically Improves Sepsis Survival Rate

    Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...
    • haidut
    • Thread
    • endotoxin energy fao fas fasn fatty acid oxidation fatty acid synthase infection inhibit inhibitor randle cycle sepsis tlr tlr4
    • Replies: 6
    • Forum: Scientific Studies
  8. haidut

    MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

    Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS - i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology...
    • haidut
    • Thread
    • ceramides fao fatty acid oxidation glucose insulin resistance lps mitochondria mitochondrial function ms multiple sclerosis randle cycle tlr tlr4
    • Replies: 45
    • Forum: Scientific Studies
  9. haidut

    Increased Fat Oxidation (FAO) Does Not Lead To Weight / Fat Loss

    The study below directly contradicts a mantra commonly repeated in nutrition circles - restrict glucose and increase fat oxidation in order to lose body fat. In fact, this idea is so ingrained into the minds of most people that I often get hate mail from people all over the world angrily...
    • haidut
    • Thread
    • deleterious diabetes energy fao fat fatty acid oxidation harmful homeostasis insulin sensitivity metabolism negative oxidation randle cycle weight
    • Replies: 34
    • Forum: Scientific Studies
  10. haidut

    Saturated Fats (SFA) Increase Glucose Oxidation While PUFA Decrease It

    This is great human study that addresses two key questions people have often asked Peat in regards to SFA vs. PUFA. As Peat has mentioned several times, during stress (exercise in this case) PUFA is preferentially oxidized while SFA is stored. The preferential oxidization of PUFA during stress...
    • haidut
    • Thread
    • differential effects fatty acid oxidation glucose metabolism glucose oxidation metabolism pdh pufa randle cycle saturated fat sfa
    • Replies: 82
    • Forum: Scientific Studies
  11. haidut

    Estrogen As The Main Cause Of Cancer And Its Progression

    I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...
    • haidut
    • Thread
    • cancer estrogen estrogen receptor fatty acid oxidation glycolysis hif hif-1 hypoxia lactate lactic acid mitochondria nad/nadh pdh pdk pyruvate randle cycle redox homeostasis warburg cause warburg cycle warburg effect
    • Replies: 18
    • Forum: Scientific Studies
  12. Westside PUFAs

    Natalie Zimmerman: "The Woefully Misguided War On Carbohydrates"

    Natalie Zimmerman of McCarbthyism: "A channel devoted to promoting a scientific understanding of carbohydrates and their essential role in the human diet. We don't practice McCarbthyism, the irrational fear mongering that views our natural desire to eat carbohydrates as the primary reason for...
  13. haidut

    The Fatty Acid Syndrome (Randle Cycle)

    This is the original study that postulated the existence of the Randle Cycle. I strongly recommend that everyone reads it as it will likely dispell whatever doubts you may have had about Peat and his ideas. I have posted many other studies that directly support the role of the Randle Cycle in...
  14. haidut

    The Randle Effect In Action (human Study)

    This was a human study and it directly confirms Peat's views on what causes insulin resistance - elevated fatty acids, through the Randle effect, block oxidation of sugar. It would have been really helpful if the study looked at what happened after restoration of "normal" diet - i.e. how long...
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