insulin resistance

  1. haidut

    Elevated PUFA In Blood Drive Metabolic Syndrome And Diabetes

    Some good evidence on the role of PUFA and inflammation in obesity and diabetes. The findings that FFA are elevated in obese people is not surprising and even mainstream medicine has wisened up to that fact. The surprising (for the authors) part was that unsaturated fats were involved in the...
    • haidut
    • Thread
    • diabetes dietary fats inflammation insulin resistance linoleic linoleic acid metabolic syndrome obesity omega-6 pufa unsaturation
    • Replies: 41
    • Forum: Scientific Studies
  2. haidut

    Fats Cause Cause Cognitive Impairment And Insulin Resistance In The Brain

    The topic of whether fats cross the BBB is very controversial, especially in light of recent evidence that dementias like Alzheimer are simply so-called "diabetes of the brain". It is well-known in clinical circles that fats do cause insulin resistance, but the PUFA lobby is powerful enough to...
    • haidut
    • Thread
    • bbb cause cognitive impairment cross fat ffa insulin resistance pass triglycerides
    • Replies: 20
    • Forum: Scientific Studies
  3. haidut

    Serotonin Causes Obesity And Diabetes In Humans

    This study is presented as groundbreaking and unexpected but in fact big pharma has been quietly working on anti-serotonin therapy for obesity/diabetes for more than a decade. I think the importance of this study is the admission that serotonin causes obesity/diabetes in humans, as one of the...
    • haidut
    • Thread
    • causative diabetes endotoxin gut humans insulin resistance metabolism obesity serotonin
    • Replies: 63
    • Forum: Scientific Studies
  4. haidut

    Estrogen+PUFA Esters May Drive Obesity; Most Doctors Have Not Even Heard Of Them

    An unassailable dogma in endocrinology is that menopause is characterized by low estrogen levels. The fact that plasma levels are only indicative of ovarian activity is conveniently overlooked, as is the fact that fat tissue grows after menopause and fat is the primary source of estrone (estrone...
    • haidut
    • Thread
    • ester esters estradiol estrogen estrone insulin resistance obesity pufa
    • Replies: 9
    • Forum: Scientific Studies
  5. P

    Low Dose Doxycycline Decreases Systemic Inflammation And Improves Glycemic Control, Lipid Profiles,

    Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in <i>db/db</i> mice Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in...
    • paymanz
    • Thread
    • a1c adiponectin advanced glycation end products antiinflammatory apoptosis beta cells diabetes doxycycline endotoxin glycogen inflammation insulin insulin resistance insulin sensitivity lps minocycline mmp inhibitor obesity tetracycline tnf
    • Replies: 5
    • Forum: Articles & Scientific Studies
  6. haidut

    Biomarkers Of Muscle And Liver Insulin Resistance

    I am posting this study mostly as a heads-up for @Dan Wich and his website for lab test comparison. I know quite a few people here struggle with insulin resistance but the doctors do not know how to test for it beyond the simple fasting blood glucose (which is unreliable and easily skewed by...
    • haidut
    • Thread
    • biomarker fetuin glucocorticoid insulin resistance liver muscle myostatin
    • Replies: 24
    • Forum: Scientific Studies
  7. haidut

    Androgen Deficiency As The Main Cause Of Chronic Disease In Males

    This is one of the most comprehensive reviews that I have ever come across on the topic of androgens and their role in male health. It is authored by one of the most renowned experts in urology - the former director of the Department of Urology at Boston University (BU) School of Medicine. Given...
    • haidut
    • Thread
    • aging androgen deficiency androgen deprivation cvd dht diabetes dutasteride finasteride heart attack heart disease hepatocellular carcinoma insulin resistance liver cancer liver disease males mitochondrial dysfunction nafld sexual dysfunction stroke testosterone
    • Replies: 108
    • Forum: Scientific Studies
  8. P

    Betaine Lowers FFA And Improve Insulin Sensitivity And Adiponectine Level In High Fat Fed Animal

    Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease Endoplasmic reticulum (ER) stress plays a critical role in adipose tissue dysfunction and insulin resistance in a variety of experimental...
    • paymanz
    • Thread
    • adiponectin betaine choline diabetes fibrosis free fatty acids insulin resistance insulin sensitivity jnk leptin liver disease liver steatosis resistin
    • Replies: 7
    • Forum: Articles & Scientific Studies
  9. haidut

    Endotoxin (LPS) Theory Of Atherosclerosis (CVD)

    I posted a study more than year ago, which examined the role of NO in aging and disease. The Nitric Oxide (NO) Theory Of Aging One of the main endogenous stimulators of NO synthesis is endotoxin (LPS). It turns out that the connection between LPS and CVD has been studied for a long time in...
    • haidut
    • Thread
    • atherosclerosis causative cvd diabetes endotoxin inflammation insulin resistance lps obesity stress stroke tlr4
    • Replies: 24
    • Forum: Scientific Studies
  10. haidut

    Exercise + Fasting Is Stress, Causes Obesity And IR, And Requires Cortisol Blockade To Reverse

    I think this thread will ring true for all people who at some in their lives exercised in order to lose weight. Just like fasting, it works great in younger age (<30) but it really masks a bigger metabolic problem and of course badly backfired in the long run. Exercise is a forced/stressed...
    • haidut
    • Thread
    • antagonist caloric restriction corticol dhea exercise fasting glucocorticoid insulin resistance mifepristone obesity progesterone receptor ru486 stress
    • Replies: 148
    • Forum: Scientific Studies
  11. haidut

    More Than One Third Of Americans Have Diabetes Or Pre-diabetes

    So much for the "indisputably improving" health of the nation as every HHS secretary since the Vietnam War has officially claimed. Up until recently the claim was that while the nation was getting quite visibly obese by the day that was not translating into adverse health outcomes. Well, so much...
    • haidut
    • Thread
    • america diabetes insulin resistance obesity pre-diabetes rates rising usa
    • Replies: 8
    • Forum: Scientific Studies
  12. Mito

    Relation Of Total Sugars, Fructose And Sucrose With Incident Type 2 Diabetes

    BACKGROUND: Sugar-sweetened beverages are associated with type 2 diabetes. To assess whether this association holds for the fructose-containing sugars they contain, we conducted a systematic review and meta-analysis of prospective cohort studies. INTERPRETATION: Current evidence does not allow...
  13. haidut

    Alzheimer Disease (AD) May Be Simply Diabetes Of The Brain

    I touched upon this topic in one of the Danny Roddy shows we did last year but the evidence since then has continues to accumulate that AD is entirely a metabolic disorders, basically identical to diabetes but focusing on the brain. A recent study found that delirium, an acute form of...
    • haidut
    • Thread
    • ad alzheimer's brain dementia dhea diabetes glucose inhibitor insulin resistance memantine potassium channel
    • Replies: 13
    • Forum: Scientific Studies
  14. haidut

    Insulin Resistance As An Endocrine Disorder

    This argument has flared up so many times on this forum and I doubt we have reached any agreement. I am on the side that insulin resistance and obesity are endocrine disorders. There is a group here that maintains that it is the obesity that really triggers it all. This study discusses some of...
    • haidut
    • Thread
    • adrenaline cortisol diabetes disorder endocrine hpa hypothyroidism insulin resistance obesity stress
    • Replies: 22
    • Forum: Scientific Studies
  15. P

    Diabetogenic Impact Of Long-chain Omega-3 Fatty Acids On Pancreatic Beta-cell Function And The Regul

    Diabetogenic impact of long-chain omega-3 fatty acids on pancreatic beta-cell function and the regulation of endogenous glucose production. - PubMed - NCBI Abstract In healthy individuals, peripheral insulin resistance evoked by dietary saturated lipid can be accompanied by increased insulin...
  16. P

    Insulin Resistance In Brain Alters Dopamine Turnover, Causes Behavioral Disorders,anxiety,Depression

    Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. - PubMed - NCBI Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a...
  17. P

    Brain Insulin Resistance Identified As Possible New Link Between Alzheimer's Disease, Diabetes

    It says brains inability to burn glucose is responsible for Alzheimer's disease.caused by insulin's resistance in brain, and that probably mediated by inflammation. Brain Insulin Resistance Contributes to Cognitive Decline in Alzheimer's Disease – PR News...
  18. P

    A Central Role For JNK(inflammation) In Obesity And Insulin Resistance

    A central role for JNK in obesity and insulin resistance. - PubMed - NCBI Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of this association are poorly understood. The c-Jun amino-terminal...
  19. P

    Inflammation Mediates Free Fatty Acid-induced Insulin Resistance

    JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. - PubMed - NCBI Lipid infusion and high fat feeding are established causes of systemic and adipose tissue insulin resistance. In this study, we treated 3T3-L1 adipocytes with a mixture...
  20. P

    DHT Levels Inversely Associated With Insulin Resistance Among Older Men

    Testosterone, Dihydrotestosterone, Sex Hormone Binding Globulin and Incident Diabetes among Older Men: the Cardiovascular Health Study. - PubMed - NCBI Abstract CONTEXT: Although sex hormone binding globulin (SHBG) and testosterone (T) have been inversely associated with risk of diabetes...
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