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Insulin Resistance In Brain Alters Dopamine Turnover, Causes Behavioral Disorders,anxiety,Depression

Discussion in 'Articles & Scientific Studies' started by paymanz, Feb 8, 2017.

  1. paymanz

    paymanz Member

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    Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. - PubMed - NCBI


    Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a brain-specific knockout of the insulin receptor (NIRKO mice) exhibit brain mitochondrial dysfunction with reduced mitochondrial oxidative activity, increased levels of reactive oxygen species, and increased levels of lipid and protein oxidation in the striatum and nucleus accumbens. NIRKO mice also exhibit increased levels of monoamine oxidase A and B (MAO A and B) leading to increased dopamine turnover in these areas. Studies in cultured neurons and glia cells indicate that these changes in MAO A and B are a direct consequence of loss of insulin signaling. As a result, NIRKO mice develop age-related anxiety and depressive-like behaviors that can be reversed by treatment with MAO inhibitors, as well as the tricyclic antidepressant imipramine, which inhibits MAO activity and reduces oxidative stress. Thus, insulin resistance in brain induces mitochondrial and dopaminergic dysfunction leading to anxiety and depressive-like behaviors, demonstrating a potential molecular link between central insulin resistance and behavioral disorders.

    https://www.sciencedaily.com/releases/2015/03/150302121504.htm

     
  2. Regina

    Regina Member

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    Does it mean diabetes can be cured by MAO inhibitors?
     
  3. GAF

    GAF Member

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    What does dopamine turnover mean?

    Too much d? Too little d? Or d is inactivated before it can do its thing? Anybody know?
     
  4. OP
    paymanz

    paymanz Member

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    I'm not sure about that,MAOIs may also increase serotonin levels,isn't that?!

    What made these studies interesting for me was the coonection between insulin and brain function, maybe what we need to do is to improve insulin level/sensitivity in body.

    Its impaired insulin function that caused these abnormal MAO/dopamine levels,in this study!
     
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