cognition

Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...

A new study demonstrating that even short-term (less than a month) exposure to polluted air impaired cognition in humans, and that the mechanism of action was by triggering an inflammatory response. Ergo, anti-inflammatory drugs (NSAID) and especially aspirin, were found to be protective. Since...

What inspired me to write this article is overall reductionism when it comes to mental function. Far too many people want to focus on specific neurotransmitters and blame certain ones for certain conditions (e.g. low dopamine in anhedonia), but health as a whole started to deteriorate first, and...

Intermittent fasting is still somewhat of a hot topic as it does give some people benefits (temporary and some long term). I think one of the most reasons why it works is often overlooked because a lot of people are unaware of it. I want to bring awareness to this reason and also to the fact...

Over the last 2 decades a large number of studies have come out demonstrating that the withdrawal symptoms in "addicts" are due largely due to elevated serotonin and adrenaline. As such, drugs such as cyproheptadine, clonidine, propranolol, etc have been successfully used off-label for treating...

I made a few posts in the past about the altruism of plants, as well as their apparent consciousness (affected by anesthesia) despite the fact that they do not have a nervous system. The article below describes additional experiments demonstrating that plants are apparently capable of a number...

A nice article showing that the one of the most uniquely human aspect of our existence - language - is actually a capacity that much "lower" animals possess as well, and may be even more adept than us at using. Apparently, prairie dogs are not only capable of verbalizing sentences with just...

The condition known as “chemobrain” is notorious among cancer survivors and many other patients undergoing toxic interventions with chemotherapy and may affect up to 85% of cancer patients. It amounts to severe cognitive dysfunction, memory problems, and even personality changes that result in...

I know the findings of this study probably won't come as surprise to many forum users but they are nonetheless worth pointing out given their potential for dramatically shifting how medicine views the brain. While Peat has written many times about long range communication between cells that...

Some people on the forum like @Wagner83 myself and a few others have tried the infamous herb TT with the hope of raising androgens and improving body composition. Despite Wikipedia bashing TT and raising doubts about its effectiveness, there is plenty of evidence from human trials shows the herb...

A human study, and as such very relevant. The dose (4g daily for 12 weeks) was a bit on the high end but that was probably because the scientists designing the trial were unaware of the studies showing benefits of taurine plateau after 2g daily. In any event, good news for those with mood/mental...

This mechanism of pregnenolone is one of the proposed methods through which it enhances neurogenesis, memory, mood and even motor function. Low doses pregnenolon improve sleep quality and are even mildly sedating, which may also be due to the activation of the glycine receptor. Subunit-specific...

I suppose the results of this study are to be expected but I wanted to post it anyways since it was one of the few human studies using methylene blue. The doses used was pretty high (4mg/kg for human) but for some reason the authors claim that this is actually a pretty low dose. Be that as it...

The study was actually on how stress damages cognition, and based on another study I posted and the drug used in the study to block the effects of stress I inferred that pregnenolone would work just as well. The study discovered that the release of CRF / CRH as part of the stress response is...

I already posted several studies showing that stress elevates estrogen in males. So much for estrogen being a beneficial female hormone. Acute stress persistently enhances estrogen levels in the female rat. - PubMed - NCBI "...Here we tested whether exposure to either tailshock or swim stress...

Influence of anxiety symptoms on improvement of neurocognitive functions in patients with major depressive disorder: A 12-week, multicenter, random... - PubMed - NCBI http://tinyurl.com/hyuogod

The Magical Thing Eating Chocolate Does to Your Brain :crazy: lolol The magical thing eating chocolate does to your brain

I receive many emails challenging Peat's assertion that estrogen is a stress hormones and that it rises under conditions of both acute and chronic stress. Cortisol is the stress hormones they say, leave estrogen alone. Well, not according to this study. Also, estrogen damages the negative...

Transcribed by moss 11 December 2014 Verified by Sheila 14 December 2014 (special thanks) Memory, Cognition & Nutrition KMUD - Ask Your Herb Doctor – (2014) HD – Andrew Murray RP – Ray Peat Ph.D HD: Hi - Dr Peat - you with us? RP: Hi. HD: OK, I just want to begin tonight’s show, as always...