cognition

It is rare to find a study like the one below that combines so many crucial topics into a unified message. Namely, the role of energy in aging and disease, the role of oxidative glucose metabolism in aging and health, the pathological role of PUFA as a negative (glucose) metabolic regulator and...

This is one of the studies that Big Pharma will probably spend a lot of money on trying to get retracted. It directly demonstrates that elevated serotonin (5-HT) in the brain drives brain atrophy and depression. Both the rates and severity of these conditions increase with aging and the study...

It seems that consuming pure egg white will indeed make you stupid enough to consume pure egg white. Key Points - Calorie restriction improves mental test performance in mice. - Adding tryptophan into calorie-restricted diet abolished memory benefits. - Giving C.R. mice the serotonergic drug...

A short video I felt like making. Often times I hear rather stubborn arguments about the blight of technologies that, I believe, can be of great help rather than a blight if used properly.

Wanted to share another snippet of Ray's that I've listened to many times over: I feel like most people I've met fall into this authoritarian mindset where they accept the conventional wisdom / advice from 'experts' and don't question things enough. I've been in that state for most of my life...

...whether you are 18 or 80. Yes, I know it is hard to believe this statement but that is the conclusion of the study after examining the link between lifestyle (and environment) and cognitive function in a group of people with ages spanning the 18-89 years interval. The conclusion of the study...

One of the few direct studies with P5 in-vivo, though that may be changing as I noticed the rate of articles on P5 has been rising over the last 5-6 years. This study used four (4) administrations of P5, at a HED of just 0.3mg/kg, 1, 6, 12, and 18 hours after the (ischemic) stroke was caused...

Yet another study demonstrating that many of the "mysterious" benefits of exercise most likely have nothing to do with the (insignificant) amount of extra calories burned, but are due to peripheral effects related to metabolism and redox balance. Namely, the study below investigates the...

I’d love to know peoples’ thoughts on how Lion’s mane mushroom & methylene blue compare. From what I understand, both are useful for improved mental clarity, memory, and they have potential in cases of Alzheimer’s. I just ordered some methylene blue, and am curious/excited to experiment with...

Just a quick announcement that we have replaced the 5α-DHP in our store with allopregnanolone. The main reason for switching over to allopregnanolone is that we always wanted to provide that steroid right from the start, however we could not find a lab willing to synthesize it. Thus, 5α-DHP...

A new study demonstrating that even short-term (less than a month) exposure to polluted air impaired cognition in humans, and that the mechanism of action was by triggering an inflammatory response. Ergo, anti-inflammatory drugs (NSAID) and especially aspirin, were found to be protective. Since...

What inspired me to write this article is overall reductionism when it comes to mental function. Far too many people want to focus on specific neurotransmitters and blame certain ones for certain conditions (e.g. low dopamine in anhedonia), but health as a whole started to deteriorate first, and...

Intermittent fasting is still somewhat of a hot topic as it does give some people benefits (temporary and some long term). I think one of the most reasons why it works is often overlooked because a lot of people are unaware of it. I want to bring awareness to this reason and also to the fact...

Over the last 2 decades a large number of studies have come out demonstrating that the withdrawal symptoms in "addicts" are due largely due to elevated serotonin and adrenaline. As such, drugs such as cyproheptadine, clonidine, propranolol, etc have been successfully used off-label for treating...

I made a few posts in the past about the altruism of plants, as well as their apparent consciousness (affected by anesthesia) despite the fact that they do not have a nervous system. The article below describes additional experiments demonstrating that plants are apparently capable of a number...

A nice article showing that the one of the most uniquely human aspect of our existence - language - is actually a capacity that much "lower" animals possess as well, and may be even more adept than us at using. Apparently, prairie dogs are not only capable of verbalizing sentences with just...

The condition known as “chemobrain” is notorious among cancer survivors and many other patients undergoing toxic interventions with chemotherapy and may affect up to 85% of cancer patients. It amounts to severe cognitive dysfunction, memory problems, and even personality changes that result in...

I know the findings of this study probably won't come as surprise to many forum users but they are nonetheless worth pointing out given their potential for dramatically shifting how medicine views the brain. While Peat has written many times about long range communication between cells that...

Some people on the forum like @Wagner83 myself and a few others have tried the infamous herb TT with the hope of raising androgens and improving body composition. Despite Wikipedia bashing TT and raising doubts about its effectiveness, there is plenty of evidence from human trials shows the herb...

A human study, and as such very relevant. The dose (4g daily for 12 weeks) was a bit on the high end but that was probably because the scientists designing the trial were unaware of the studies showing benefits of taurine plateau after 2g daily. In any event, good news for those with mood/mental...