allblues
Member
- Joined
- Oct 30, 2015
- Messages
- 225
I thought this was cool: https://www.sciencedirect.com/science/article/abs/pii/S0006899313004642?via=ihub
For the other half though, no such luck.
Decreases in 5-HTT expression were associated with the stress-induced anhedonic state, whereas increases were associated with the stress-induced non-anhedonic state. Following FLX treatment, the changes in 5-HTT expression were reversed in a subpopulation of anhedonic mice, i.e., the treatment-responsive anhedonic mice.
Fluoxetine (SSRI) actually managed to increase SERT expression in about half of the anhedonic mice, attenuating their anhedonic symptoms.The data indicate that down-regulation of hippocampal 5-HTT protein expression is a signature change associated with anhedonia, a key endophenotype of clinical depression. Differential changes in 5-HTT expression may contribute to variations in the susceptibility to anhedonia.
For the other half though, no such luck.