Stress-induced Anhedonia Correlated With Lower Serotonin Transporter Expression

allblues

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I thought this was cool: https://www.sciencedirect.com/science/article/abs/pii/S0006899313004642?via=ihub
Decreases in 5-HTT expression were associated with the stress-induced anhedonic state, whereas increases were associated with the stress-induced non-anhedonic state. Following FLX treatment, the changes in 5-HTT expression were reversed in a subpopulation of anhedonic mice, i.e., the treatment-responsive anhedonic mice.
The data indicate that down-regulation of hippocampal 5-HTT protein expression is a signature change associated with anhedonia, a key endophenotype of clinical depression. Differential changes in 5-HTT expression may contribute to variations in the susceptibility to anhedonia.
Fluoxetine (SSRI) actually managed to increase SERT expression in about half of the anhedonic mice, attenuating their anhedonic symptoms.
For the other half though, no such luck.
 

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