Low Toxin Lifestyle "Short List of What the Toxin Known as “vitamin” A Can do to You"

[charlie]

View: https://twitter.com/NutriDetect/status/1755693547024752812

 

[Peatress]

Vitamin A is not a toxin but it can harm you if you over do it.

 

[charlie]

Vitamin A is not a toxin but it can harm you if you over do it.

I disagree. "vitamin A" is a toxin.

 

[Peatress]

I disagree. "vitamin A" is a toxin.

I know you do, that's fine. I think it's an important nutrient.

 

[charlie]

I know you do, that's fine. I think it's an important nutrient.

That is what the Rockefellers would have you think. Their science is bunk.

 

[Peatress]

That is what the Rockefellers would have you think. Their science is bunk.

Dr. Peat didn't think so. I don't care about Rockefellers.

 

[Mr Joe]

So in that picture there is 99% diseases of the world. All caused by vit A. Are you not seeing how manipulatives are these tweets ?

 

[charlie]

Dr. Peat didn't think so. I don't care about Rockefellers.

He was using their science. Doesn't make Peat a bad person, he was just on the bad science. Are you not overweight on a Peat inspired diet?

So in that picture there is 99% diseases of the world. All caused by vit A. Are you not seeing how manipulatives are these tweets ?

But what if it is all caused by "vitamin A"? Would you not feel very silly if you were fighting against the world healing?

 

[InChristAlone]

I found something that backs up Grant Genereux's research: this paper on sorbents talks about heavy metals, the chart says when there is a deficiency of zinc it causes an apparent need for vitamin A !!!!!!

https://www.sciencedirect.com/science/article/pii/S2215038221001850#bb0170

 

[tenkaypm]

supplementing vit A doesn't have the side effects of accutane though. maybe a comparatively very small amount transforms into it? post doesn't seem relevant in itself

 

[md_a]

I disagree. "vitamin A" is a toxin.

I am 45 years old, I have been eating foods rich in vitamin A since childhood, I am muscular and healthy. To understand my case, vitamin A is not a toxin? I know about Ray Peat since 2009. I think it makes sense if you go from vitamin A toxicity to aldehyde toxicity, and thus it makes sense and covers a whole palette of toxins that harm through this system, when the metabolism no longer has enough energy to eliminate them properly.

`Retinol is considered to be "vitamin A alcohol," and causes similar problems as alcohol, including birth defects known as fetal retinoid syndrome.
It's metabolized by the same dehydrogenase enzymes as alcohol and methanol, which creates aldehydes.
Much better would be to support the dehydrogenase system and eliminate the build up of toxic aldehydes.`



Most aldehydes are highly reactive chemicals that can cause harm to living organisms. However, some aldehydes are produced naturally within the body as a result of normal metabolic processes. For example, acetaldehyde is a byproduct of alcohol metabolism, and formaldehyde is produced during the breakdown of certain amino acids.

Lipid peroxidation is a process that occurs when free radicals attack lipids, leading to the formation of various reactive aldehydes, such as malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and acrolein. These aldehydes can accumulate in the body and cause toxicity.



Malondialdehyde (MDA) is one of the most commonly studied aldehydes produced during lipid peroxidation. It is a mutagenic compound that can modify DNA bases, leading to mutations and chromosomal aberrations. MDA has been linked to various diseases, including atherosclerosis, cancer, and neurodegenerative disorders.



4-Hydroxynonenal (4-HNE) is another aldehyde produced during lipid peroxidation. It is highly reactive and can form adducts with proteins, nucleic acids, and lipids, leading to cellular damage. 4-HNE has been implicated in the pathogenesis of various diseases, including atherosclerosis, diabetes, and neurodegenerative disorders.



Acrolein is a highly reactive aldehyde that can be produced during lipid peroxidation and is also found in tobacco smoke. It is a potent irritant and can cause damage to the respiratory and nervous systems.



The toxicity of aldehydes produced during lipid peroxidation can be attributed to their ability to modify proteins, lipids, and nucleic acids, leading to cellular damage and dysfunction. Strategies aimed at reducing lipid peroxidation and aldehyde toxicity include consuming a diet rich in antioxidants, avoiding tobacco smoke, and reducing exposure to environmental pollutants.

Excessive intake of vitamin A can lead to a condition called hypervitaminosis A, which can cause symptoms of aldehyde toxicity. This is because vitamin A is metabolized into retinaldehyde and then into retinoic acid in the body, and retinoic acid can accumulate and cause toxicity at high levels.



Symptoms of aldehyde toxicity from vitamin A toxicity can include headache, dizziness, nausea, vomiting, double vision, skin irritation, hair loss, and joint pain. In severe cases, it can lead to liver damage, bone fragility, and even death.



Under normal circumstances, the body has mechanisms in place to detoxify and eliminate these aldehydes. However, in certain situations, such as heavy alcohol consumption or exposure to high levels of environmental aldehydes, these mechanisms can become overwhelmed, leading to toxicity.



Symptoms of aldehyde toxicity from inside the body can vary depending on the specific aldehyde involved and the severity of the exposure. However, common symptoms may include headache, nausea, vomiting, dizziness, and difficulty breathing. More severe cases can lead to neurological damage, liver and kidney damage, and even death.



Environmental exposure to aldehydes can come from various sources, and different types of aldehydes can cause different health effects. Here are some examples of aldehydes commonly found in the environment and their potential health impacts:



Formaldehyde: Found in building materials, pressed wood products, carpeting, furniture, household cleaners, and tobacco smoke. Can cause irritation of the eyes, nose, throat, and skin, and may be linked to cancer.

Acetaldehyde: Present in tobacco smoke, vehicle exhaust, and industrial emissions. May cause irritation of the eyes, nose, and throat, and has been linked to an increased risk of cancer.

Benzaldehyde: Used in perfumes, flavors, and fragrances, and found in some foods and beverages. Can cause irritation of the eyes, nose, throat, and skin, and may be toxic to the nervous system.

Crotonaldehyde: Produced during combustion of fuels, cigarettes, and biomass, and found in indoor air pollution. Can cause irritation of the eyes, nose, throat, and skin, and may be linked to an increased risk of cancer.

Glutaraldehyde: Used as a disinfectant and sterilant in hospitals, laboratories, and industrial settings. Can cause irritation of the eyes, nose, throat, and skin, and may be toxic to the respiratory system.

Propionaldehyde: Used in the manufacture of plastics, rubber, and resins, and found in tobacco smoke. Can cause irritation of the eyes, nose, throat, and skin, and may be toxic to the nervous system.



Aldehydes can also be present in food and can cause toxicity if consumed in high amounts. Aldehydic compounds can be produced during food preparation, storage, or cooking, particularly at high temperatures.



Some of the aldehydes found in food include:



Acetaldehyde: Found in fermented beverages, bread, and pickled foods. It is also produced during the metabolism of alcohol in the body.

Furfural: Found in roasted coffee, beer, and certain cereals. It is produced during the heating and roasting of grains and sugars.

Trans, trans-2,4-decadienal: Formed during the deep-frying of vegetable oils and is also found in some snack foods.

Acrolein: Formed during the thermal decomposition of glycerol, a component of fats and oils. It is also found in tobacco smoke.

Exposure to high levels of aldehydes in food can cause toxicity and lead to symptoms such as nausea, vomiting, diarrhea, and abdominal pain. In severe cases, it can lead to liver and kidney damage, respiratory problems, and even death.



Aldehydes can accumulate in human fat. Aldehydes are reactive chemicals that can be produced by the body or ingested through food, water, or air. They can react with other molecules in the body and form stable adducts, which can then accumulate in fat tissues.



One example is acrolein, a potent aldehyde that is produced during the combustion of fossil fuels and is also found in tobacco smoke. Acrolein has been shown to accumulate in human adipose tissue, where it can persist for long periods of time. Similarly, other aldehydes such as formaldehyde and acetaldehyde can also accumulate in human fat.



High levels of aldehydes in the body can be toxic and have been linked to various health problems, including respiratory and neurological disorders, cancer, and cardiovascular disease. Accumulation of aldehydes in human fat may therefore contribute to the development of these conditions.



Reducing exposure to aldehydes through diet, air quality, and other lifestyle factors can help reduce the burden of these chemicals in the body and potentially lower the risk of associated health problems.

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Aldehyde toxicity is characterized by cell-localized, micronutrient deficiencies in sulfur-containing antioxidants, thiamine (B1), pyridoxine (B6), folate, Zn2+, possibly Mg2+, and retinoic acid, causing oxidative stress and a cascade of metabolic disturbances. Aldehydes also react with selective cytosolic and membrane proteins in the cell of origin; then some types migrate to damage neighboring cells. Reactive aldehydes also form adducts with DNA, selectively mutating bases and inducing strand breakage. This article reviews the relevant genomic, biochemical, and nutritional literature, which supports the central hypothesis that most ASD symptoms are consistent with symptoms of aldehyde toxicity. The hypothesis represents a paradigm shift in thinking and has profound implications for clinical detection, treatment, and even prevention of ASD. Insight is offered as to which neurologically afflicted children might successfully be treated with micronutrients and which children are unlikely to be helped. The aldehyde toxicity hypothesis likely applies to other neurological disorders.



...

Abstract

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated. Although the human genome has 19 ALDH genes, one ALDH emerges as a particularly important enzyme in a variety of human pathologies. This ALDH, ALDH2, is located in the mitochondrial matrix with much known about its role in ethanol metabolism. Less known is a new body of research to be discussed in this review, suggesting that ALDH2 dysfunction may contribute to a variety of human diseases including cardiovascular diseases, diabetes, neurodegenerative diseases, stroke, and cancer. Recent studies suggest that ALDH2 dysfunction is also associated with Fanconi anemia, pain, osteoporosis, and the process of aging. Furthermore, an ALDH2 inactivating mutation (termed ALDH2*2) is the most common single point mutation in humans, and epidemiological studies suggest a correlation between this inactivating mutation and increased propensity for common human pathologies. These data together with studies in animal models and the use of new pharmacological tools that activate ALDH2 depict a new picture related to ALDH2 as a critical health-promoting enzyme.

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities - PubMed

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that accumulate through metabolism and to which we are exposed from the environment has been elucidated. Although the human genome has 19 ALDH genes...

pubmed.ncbi.nlm.nih.gov

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In addition to the direct reactions between aldehydes and micronutrients, the alcoholism literature suggests that alternative mechanisms may induce a deficiency in the retinoic acid form of vitamin A particularly in those individuals with heritable forms of alcoholism. Ethanol is known to compete directly for the retinol-binding site on the ADHs involved in the rate-limiting step of retinol oxidation, thereby decreasing the amount of retinal and retinoic acid that is ultimately produced. Because retinoic acid controls the regulation of fetal development, neuronal growth, differentiation, and limb morphogenesis, ethanol-induced deficiencies of retinoic acid are believed to play a major role in fetal alcohol syndrome disorder (FASD).50,51 Retinoic acid also plays a major role in epigenetic changes in the cell.49 In many ways, the symptoms of FASD mimic those of the complex form of ASD, suggestive of a problem during embryonic development.52 Moreover, many ASD children suffer from hypovitaminosis A,53,54 which is commonly attributed to highly restrictive diets or to intestinal malabsorption. However, some reports indicate that the same children do not have night blindness,53 and some reports suggest that ASD symptoms are reduced by retinol treatment.54 The lack of night blindness in ASD cases of vitamin A deficiencies suggests that retinal is present, but conversion to retinoic acid is blocked. An accumulation of retinal would have the same toxicity consequences as other endogenous aldehydes but with the added problem that a deficiency in retinoic acid would disrupt the retinoic acid response element (RARE)-dependent transcription of many key proteins in embryonic and neuronal development...



Summary



The many symptoms and divergent theories of ASD are consistent with aldehyde toxicity in which reactive aldehydes accumulate as a consequence of errors associated with genes intended to oxidize, reduce, or otherwise neutralize aldehydes. No matter the source(s) of the accumulated aldehydes, all share a reactive chemical group, which inflicts similar types of intracellular damage, but also suggests that a common treatment plan will be beneficial to many with ASD. Aldehydes induce localized micronutrient deficiencies initiating a cascade of metabolic disturbances in hundreds of metabolic pathways, cause oxidative stress, inactivate proteins by adduct formation, and bind to DNA, ultimately causing mutations and strand breakage. These effects of aldehyde toxicity explain all of the current genetic and biochemical theories of ASD in the medical literature. In addition to damage done by lipid peroxidation-generated aldehydes, already recognized by some experts in ASD,84–87 the central hypothesis expands to other types of endogenous and exogenous aldehydes. The aldehyde toxicity hypothesis has profound implications for early clinical detection and treatment of ASD as well as its prevention. Due to the high risk of permanent, irreversible cellular damage, time is of the essence for treating aldehyde toxicity. Treatment for aldehyde toxicity is similar to nutritional plans already advocated in the orthomolecular community76 but with a few additional features: (1) one or more sulfur-containing antioxidants are essential to neutralize reactive aldehydes and (2) a broad spectrum of micronutrients, with a special emphasis on B6, Zn2+, B1, Mg2+, folate, and retinol, should be included, irrespective of results from currently available, but inadequate, clinical testing. Such a treatment plan appears to be the best option for treating ASD now, until the genetics of ASD is better understood, and targeted therapies can be implemented. The hypothesis likely applies to many other neurological disorders, such as schizophrenia, with the major differences among disorders being the source, concentration, and reactivity of the accumulated aldehydes.



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910734/

 

[Rinse & rePeat]

Vitamin A is not a toxin but it can harm you if you over do it.

It has to be what you are saying here Peatress, otherwise why do I not have any of these issues listed above eating like Ray Peat suggested. I have only gotten better as the years go by avoiding grains and PUFA’s and upping my dairy and sugar sources.

 

[charlie]

It has to be what you are saying here Peatress, otherwise why do I not have any of these issues listed above eating like Ray Peat suggested. I have only gotten better as the years go by avoiding grains and PUFA’s and upping my dairy and sugar sources.

Just because you have not experienced the "vitamin A" cascade does not mean it's not true.

 

[Rinse & rePeat]

Just because you have not experienced the "vitamin A" cascade does not mean it's not true.

But it also doesn’t mean Ray Peat was wrong either does it? I am a strong believer in the Blood-type diet and because of these major differences in each of us, like our different blood types, may explain why some do well with Ray Peat’s recommendations and some seemingly to heal on a low vitamin A protocol. Just like diabetics have to limit meat consumption because of their impaired kidneys, it doesn’t mean we healthy people are going to be having kidney trouble if we eat meat. Maybe your vitamin A diet is working for people with worn out livers for lifelong cumulative reasons, not because of Ray Peat. Just the very fact that elevated cultures prized the liver of the animal, as well as the longest living people, proves vitamin A does not harm health people. I would say looking at all the supplements and pills people consume should be the rock to look under.