lvysaur
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In B cells, the effects of P4 treatment are less well characterized. In vitro studies with B cells and endometrial cell co-cultures from mice show that in the presence of P4, B cells have reduced expression of CD80 and CD86 and a limited ability to present antigen.55 B-cell hybridomas treated with P4 show lower cellular proliferation and antibody production.56 In murine splenic B cells, P4 treatment decreases activation-induced deaminase mRNA and the ability of these cells to undergo somatic hypermutation and class-switch recombination.57 Acute administration of P4 in combination with low dose estradiol to female mice significantly reduces B lymphopoiesis, suggesting that these hormones are negative regulators of B-cell development in bone marrow.58 During pulmonary infection, females treated with time-release capsules of either P4 and LNG exhibit lower antibody production systemically in serum and locally in brochoalveolar lavage fluid, than do non-hormone treated female mice.59 Taken together, these data illustrate that P4 and related compounds alter the functioning of immune cells, which could have profound effects on the pathogenesis of diseases at mucosal sites.
Multiple anti-B cell and reduced antibody effects of progesterone.
Progesterone-based compounds affect immune responses and susceptibility to infections at diverse mucosal sites | Mucosal Immunology