Had a early 20's female patient two days ago, on the verge of a breakdown due to almost constant hiccups. Also PCOS symptoms, not sleeping, vomiting up food. I recommended topical progesterone and a combo gut supplement that includes phages (also zinc and mushroom complex) She called today after sleeping well two nights and longest relief of hiccups in over a year. She still has a way to go with lifestyle but she is bouncing back after just two nights of progesterone!