LeeLemonoil
Member
- Joined
- Sep 24, 2016
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The GPER is defined as an "estrogen receptor" Unlike ERa and ERß, it is not a nuclear receptor. It is theorized that GPER is involved in or the reason of rapid cellular effects of estrogens.
This publication http://www.sciencedirect.com/science/article/pii/S0039128X16000544
gives some insight into its actions and states some known agonists and antagonists.
Curiously, Niacinamide is an agonist. Other agonists are Xenoestrogens and poisons like BPA, Green Tea Cathechins and other Flavanoids. Tamoxifen, a known anti-estrogenic pharmacon, is also an agonist.
The understanding of the actions of GPER is crucial to Ray Peat's theses.
As far as I'm aware, he always said tha Estrogens act rapidly and independently from estrogen receptor activation. This GPER (a protein structure in cells for all intents and purposes, no need to all it receptor really) does confirm this idea.
This publication http://www.sciencedirect.com/science/article/pii/S0039128X16000544
gives some insight into its actions and states some known agonists and antagonists.
Curiously, Niacinamide is an agonist. Other agonists are Xenoestrogens and poisons like BPA, Green Tea Cathechins and other Flavanoids. Tamoxifen, a known anti-estrogenic pharmacon, is also an agonist.
The understanding of the actions of GPER is crucial to Ray Peat's theses.
As far as I'm aware, he always said tha Estrogens act rapidly and independently from estrogen receptor activation. This GPER (a protein structure in cells for all intents and purposes, no need to all it receptor really) does confirm this idea.