OP
Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
Another reason to excrete bile quickly is its metabolism by bacteria in the gut. The microbiome reduces bile acids and Im not sure what the consequences of that are (maybe reductive stress?), but Vitamin K avoided that reaction. So another reason to take Vitamin K.
" Unsaturated 4-ene-3-oxo and 1,4-diene-3-oxo bile acids were reduced in Ring A. 5 beta-3-Oxo bile acids were reduced to 5 beta-3-hydroxy bile acids. 4-Ene, 1,4-diene and 4,6-diene-3,17-dioxo-androstanes were reduced in Ring A with concomitant reduction of oxo groups to hydroxyl groups. The Gram-negative facultative anaerobic faecal bacteria are implicated in the reductive process, whilst the genus Clostridium does not appear to be important. Inclusion of menadione, a synthetic form of vitamin K, retards the reductive process."
- Metabolism of unsaturated bile acids and androstanes by human faecal bacteria - PubMed
" Unsaturated 4-ene-3-oxo and 1,4-diene-3-oxo bile acids were reduced in Ring A. 5 beta-3-Oxo bile acids were reduced to 5 beta-3-hydroxy bile acids. 4-Ene, 1,4-diene and 4,6-diene-3,17-dioxo-androstanes were reduced in Ring A with concomitant reduction of oxo groups to hydroxyl groups. The Gram-negative facultative anaerobic faecal bacteria are implicated in the reductive process, whilst the genus Clostridium does not appear to be important. Inclusion of menadione, a synthetic form of vitamin K, retards the reductive process."
- Metabolism of unsaturated bile acids and androstanes by human faecal bacteria - PubMed
