Candeias
Member
- Joined
- Apr 29, 2018
- Messages
- 220
Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
"Two months of pterostilbene diet but not resveratrol significantly improved radial arm water maze function in SAMP8 compared with control-fed animals. Neither resveratrol nor pterostilbene increased sirtuin 1 (SIRT1) expression or downstream markers of sirtuin 1 activation. Importantly, markers of cellular stress, inflammation, and AD pathology were positively modulated by pterostilbene but not resveratrol and were associated with upregulation of peroxisome proliferator-activated receptor (PPAR) alpha expression. (...)"
It hasn't been talked about much on the forum yet but it seems to have multifaceted protective properties even at doses that don't increase SIRT1. Its high absorption rate also caught my attention.
Thoughts?
"Two months of pterostilbene diet but not resveratrol significantly improved radial arm water maze function in SAMP8 compared with control-fed animals. Neither resveratrol nor pterostilbene increased sirtuin 1 (SIRT1) expression or downstream markers of sirtuin 1 activation. Importantly, markers of cellular stress, inflammation, and AD pathology were positively modulated by pterostilbene but not resveratrol and were associated with upregulation of peroxisome proliferator-activated receptor (PPAR) alpha expression. (...)"
It hasn't been talked about much on the forum yet but it seems to have multifaceted protective properties even at doses that don't increase SIRT1. Its high absorption rate also caught my attention.
Thoughts?