Lipoic Acid Inhibits NO Synthesis As Powerfully As Methylarginine

[meatbag]

The inhibitory action of α-lipoic acid on hepatocyte NO synthesis was as potent as that of NG-monomethyl-l-arginine without obvious cytotoxicity. Deletion by diethylmaleate or inhibition by buthionine sulfoximine of intracellular glutathione caused a significant decrease in hepatocyte NO synthesis, implying that increased intracellular reduced glutathione levels could not be the reason for α-lipoic acid inhibited NO synthesis. α-Lipoic acid inhibition of NO synthesis seems to be from α-lipoic acid improved carbohydrate metabolism in hepatocytes.
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Inhibition of Nitric Oxide Synthesis in Primary Cultured Mouse Hepatocytes by a-Lipoic Acid
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a-Lipoic acid is derived from caprylic acid, which is found naturally in milk and coconut oil too;Lipoic acid - Wikipedia

 

[meatbag]

Also here's a very informative page on a-Lipoic Acid if anyone is interested:Lipoic Acid

 

[milkboi]

Interesting. I used to taking it while on Keto. It has an insulin-mimicking effect if I‘m not mistaken and it often sent me into dizzy spells because of low blood sugar. Must have had not enough Bulletproof coffee.

 

[ddjd]

The inhibitory action of α-lipoic acid on hepatocyte NO synthesis was as potent as that of NG-monomethyl-l-arginine without obvious cytotoxicity. Deletion by diethylmaleate or inhibition by buthionine sulfoximine of intracellular glutathione caused a significant decrease in hepatocyte NO synthesis, implying that increased intracellular reduced glutathione levels could not be the reason for α-lipoic acid inhibited NO synthesis. α-Lipoic acid inhibition of NO synthesis seems to be from α-lipoic acid improved carbohydrate metabolism in hepatocytes.
-
Inhibition of Nitric Oxide Synthesis in Primary Cultured Mouse Hepatocytes by a-Lipoic Acid
-
a-Lipoic acid is derived from caprylic acid, which is found naturally in milk and coconut oil too;Lipoic acid - Wikipedia

thanks for this.

any ideas whether R-Lipoic form is better than regular ?