Incredible Story Of Closed Mindedness - Man Figures Out His Diagnosis And Treatment Despite Doctors

Discussion in 'Articles & Scientific Studies' started by ecstatichamster, Jul 27, 2019.

  1. ecstatichamster

    ecstatichamster Member

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    This college dropout was bedridden for 11 years. Then he invented a surgery and cured himself — CNN

    This college dropout was bedridden for 11 years. Then he invented a surgery and cured himself

    Updated 11:40 AM EDT July 27, 2019

    Doug Lindsay was 21 and starting his senior year at Rockhurst University, a Jesuit college in Kansas City, Missouri, when his world imploded.

    After his first day of classes, the biology major collapsed at home on the dining room table, the room spinning around him.

    It was 1999. The symptoms soon became intense and untreatable. His heart would race, he felt weak and he frequently got dizzy. Lindsay could walk only about 50 feet at a time and couldn't stand for more than a few minutes.

    "Even lying on the floor didn't feel like it was low enough," he said.

    The former high school track athlete had dreamed of becoming a biochemistry professor or maybe a writer for "The Simpsons."

    Instead, he would spend the next 11 years mostly confined to a hospital bed in his living room in St. Louis, hamstrung by a mysterious ailment.

    Doctors were baffled. Treatments didn't help. And Lindsay eventually realized that if he wanted his life back, he would have to do it himself.

    His journey since has amazed medical professionals.

    "He did something extraordinary," said John Novack, spokesman for Inspire, a healthcare social network for rare and chronic-disease patients. When people hear Lindsay's story, Novack said, they often say, "I can do something similar for my kid."

    His mother was a living prophecy

    Whatever was wrong with him ran in the family.

    By the time Lindsay was 18 months old, his mother was so weak she could no longer pick him up.

    By the time he was 4 she could no longer walk. She did manage to pick him up one more time that year, when he was choking on a jawbreaker. She saved his life.

    Otherwise, she was too frail. She lived for decades, mostly bedridden with the same condition that stole her son's twenties. After years of tests, she determined her condition was related to her thyroid, but she was too sick to travel to the Mayo Clinic to get more specialized care, Lindsay said.

    Lindsay's aunt also developed the same ailment, growing so feeble she couldn't tie her own shoes.

    As a teenager, watching his family members sidelined from life, Lindsay wondered whether his body was a ticking time bomb, too.

    Finally, that day in 1999, the alarm went off.

    "When I called my mom that night to tell her I needed to drop out (of college), we both knew," he said. The family curse had struck.

    He found answers in discarded medical textbooks

    From the fall of 1999 onward, Lindsay was bedridden about 22 hours a day.

    "If I was up, it was because I was eating or going to the bathroom," he said.

    Lindsay immersed himself in medical research, determined to find a way out. He saw specialists from endocrinology, neurology, internal medicine and other specialties. When one doctor was out of ideas, he referred Lindsay to a psychiatrist.

    That's when Lindsay he realized he'd have to figure his predicament out on his own.

    While in college he had picked up a 2,200-page endocrinology textbook near a garbage can, hoping to use it to figure out what condition his mom had. In it, he found an important passage discussing how adrenal disorders could mirror thyroid disorders.

    He zeroed in on his adrenal glands, which sit atop the kidneys on either side of the lower abdomen.

    Using a stash of aging medical textbooks, Lindsay hypothesized that a whole class of autonomic nervous-system disorders could exist beyond the established categories of what most endocrinologists or neurologists knew about.

    He cobbled together cash for a computer, had an old college roommate bring it over, and got to work.

    Lindsay soon stumbled on the website for the National Dysautonomic Research Foundation, delighted that an entire organization was dedicated to researching the type of disorder plaguing him and his family. He asked the foundation to send him literature about emerging research in the field.

    None of the diseases the foundation was examining fit Lindsay's pattern of symptoms. But he was getting closer.

    He convinced a researcher who believed in him

    Lindsay soon decided he needed a partner -- not just a physician but a scientist curious enough to take on a rare case and spend long hours with him parsing it out.

    The best place to find that person, he reasoned, was at the American Autonomic Society's annual conference, attended by scientists from around the world who focused on nervous system disorders.

    In 2002, he give a presentation about his disease at the group's meeting in Hilton Head, South Carolina. To get there, Lindsay bought a row of airline tickets so that, with the help of friends, he could lay across several seats during the flight.

    Lindsay arrived at the conference in a wheelchair, wearing a suit and tie, and presented himself as a Jesuit-trained scientist. He tried to comport himself like a grad student or a junior colleague to the scholars in the audience, not like a patient.

    He was just a scientist living an experiment in his own body. During his talk, Lindsay argued that a certain drug might help him.

    Several of the scientists disagreed with Lindsay's hypotheses about his ailment. But that wasn't unexpected. He didn't even have a bachelor's degree and he was telling doctors from Harvard University, the National Institutes of Health and the Cleveland Clinic something their medical training told them was impossible.

    "They didn't patronize me. They treated me like a scientist," Lindsay said. "I was entering into a world of science I couldn't participate in because I was at home and couldn't be a grad student."

    Dr. H. Cecil Coghlan, a medical professor at the University of Alabama-Birmingham, approached Lindsay after his presentation. Coghlan said he thought Lindsay was on to something.

    At last, Lindsay had a medical ally.

    His first innovation was repurposing a drug

    In early 2004, one of Lindsay's friends rented an SUV, loaded a mattress in the back and drove him, lying flat, 500 miles to Birmingham.

    Lindsay suspected his body was producing too much adrenaline. He knew of a drug called Levophed, which is approved by the US Food and Drug Administration to raise blood pressure in some critically ill patients. Levophed is basically an injection of noradrenaline, which counters the symptoms created by excess adrenaline.

    It hadn't been done before, but Lindsay convinced Coghlan to repurpose the drug so he could live on a 24/7 noradrenaline drip for the next six years.

    Lindsay spent "every second of every day" hooked up to an IV. It stabilized his condition and allowed him to be active for short periods of time around the house.

    "I was no longer at risk of losing everything," Lindsay said.

    Still, other than doctors' visits, a high school reunion and a few weddings, Lindsay's autonomic dysfunction kept him mostly confined to the house he grew up in well beyond his twenties.

    Why was he so sick, he wondered? Something was dumping way too much adrenaline into his blood.

    Coghlan told him he might have an adrenal tumor. But three scans of his adrenal glands all came back negative.

    Discouraged but not deterred, Lindsay did the only thing he could do: He dove back into the medical literature.

    And he came up with a treasure.

    Later he diagnosed a disorder doctors didn't believe could exist

    Lindsay suspected there might be something in his adrenal gland that acted like a tumor, but wasn't one.

    A fourth scan in 2006 showed his adrenals "glowing brightly," Lindsay said, an abnormality consistent with his new theory.

    Coghlan called Lindsay and said, "We found it!" The diagnosis: bilateral adrenal medullary hyperplasia.

    In layman's terms, it means the medullas, or inner regions, of his adrenal glands were enlarged and acting like tumors. His adrenal glands were producing way too much adrenaline.

    Experts in the field doubted the diagnosis. But Coghlan put his professional reputation on the line to back it.

    As Lindsay delved into more medical literature, he found only 32 recorded cases of bilateral adrenal medullary hyperplasia.

    And he fixed on what seemed like a simple solution: If he could cut out the medullas of his adrenal glands -- sort of like slicing into a hard-boiled egg and removing the yolk -- his health would improve.

    Dr. Chris Bauer, Lindsay's personal physician, calls his ailment an "atypical presentation of a rare disease."

    "They don't really write textbooks based on that," Bauer said. "We were were all learning with Doug as we went along."

    Then he pioneered a new surgery

    Lindsay finally came to a bold conclusion. "If there isn't a surgery," he decided, "I'm going to make one."

    His first big lead came in 2008. He found a 1980 study from a scientist at Georgia State University, which he summed up as: "You slice the rat's adrenal gland with a razor blade and squeeze it so the medulla pops out like a pimple."

    Then he found that another version of the adrenal medulla extraction had been done at Harvard. Renowned professor Walter Bradford Cannon had performed the surgery on cats in 1926. Lindsay found records of the surgery being done on dogs as well.

    He built a 363-page PDF which proposed a first-ever human adrenal medullectomy.

    Then he spent the next 18 months working to find a surgeon who would oversee the unorthodox procedure.

    Pioneering a new surgery is a high-wire act for ethical and financial reasons as well. Surgeons could risk losing their license by performing an unproven operation, especially if complications arose. And insurance companies tend to not reimburse patients for non-standard procedures.

    Because many of the doctors in that specialized field knew each other, Lindsay was careful where he pitched the idea that might save his life.

    Eventually he recruited a surgeon from the University of Alabama-Birmingham. In September 2010 Lindsday went to the university hospital, where the doctor successfully extracted one of his adrenal medullas.

    Three weeks after the procedure, Lindsay could sit upright for three hours. By Christmas Eve, he had the strength to walk a mile to church.

    As he stood in the back of the church during midnight Mass, it finally felt like hope was winning.

    But progress was slow. In 2012, he underwent a second surgery at Washington University in St. Louis to remove the medulla from his remaining adrenal gland.

    A year later, he was well enough to fly with friends to the Bahamas. It was the first time in his life the Midwesterner had seen the ocean.

    By early 2014, he was coming off some of his meds.

    Coghlan, his champion, lived just long enough to see Lindsay's remarkable recovery. He died in 2015.

    Now he's helping other rare-disease patients

    Against the odds, Lindsay had found a way to save himself.

    But his mother was too delicate to be moved to another facility, let alone endure the surgery her son pioneered. She died in 2016.

    She didn't get to see him walk across the stage to graduate that year from Rockhurst University with a bachelor's degree in biology, 16 years after he originally expected to begin his career.

    Lindsay is now 41 years old. Many of the friends with whom he planned to graduate are now married, with kids in grade school.

    "You can't recapture the past," Lindsay said.

    Today he still lives in his childhood home in St. Louis. He needs to take nine medications per day, and his health is far from perfect, but he has his life back.

    He's not exactly the biology professor he dreamed of being at 21, but he's not far off the mark. He's leveraging his experience into a new career as a medical consultant.

    "I couldn't be an assistant manager at Trader Joe's. I don't have the physical ability for that," Lindsay said. "But I can travel and give speeches and go for walks. And I can try to change the world."

    Doctors are turning to him to help them identify and treat rare diseases like his own.

    "I'm a full professor at Stanford, and I don't know these answers," said Dr. Lawrence Chu, who found himself leaning on Lindsay when a rare disease patient came to him. "Doug was the expert consultant."

    Lindsay has spoken at medical schools, including Stanford and Harvard, and at a growing list of medical conferences. And he's working on a case study to be published in the British Medical Journal.

    With his gift for solving intractable problems, he hopes to help steer other patients with hard-to-treat diseases on a path toward wholeness.

    "I got help from people," he said, "and now I have to help people."

    © 2019 Cable News Network, Inc. A WarnerMedia Company. All Rights Reserved.
     
  2. Elderflower j58

    Elderflower j58 Member

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  3. OP
    ecstatichamster

    ecstatichamster Member

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    What strikes me is how scientists were open minded but doctors were not.

    So typical. Doctors are taught to be close minded.
     
  4. charlie

    charlie The Law & Order Admin

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    Incredible. Thank you for sharing. :hattip
     
  5. indeterminacy

    indeterminacy Member

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    :jawdrop: Really interesting, thanks!!:clap

     
  6. tankasnowgod

    tankasnowgod Member

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    Nice. This seems to me the most important part-

    Anyone who goes to see any medical professional should take the same sort of approach. Especially anyone on this forum. If you ever talk to a doctor, remember, you are talking to an equal.
     
  7. Hugh Johnson

    Hugh Johnson Member

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    If you have to talk to a doctor, you should have a goal in mind and plan your communication around that goal. What you are doing only works if he already sees you as an equal, and that is unlikely. Have a plan, get in, get out and tell them nothing you don't have to.
     
  8. christina

    christina Member

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    Good for him and hopefully he gets fully cured.

    The doctors weren't close minded though, they just ran out of ideas. Not all rare diseases are fully understood or known. The doctors are going to him now to help them with patients who might have rare diseases.
     
  9. raysputin

    raysputin Member

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    I think this story is more about medicine under capitalism then about the close mindedness of individuals. If you spent 1/3 if your life studying for a professional licensure I doubt you would be willing to put your license on the line no matter how altruistic you may or not be. the scientists could act in an innovative way because they had less to lose. It’s unfortunate doctors don’t get that kind of ability under their practice standards.
     
  10. OP
    ecstatichamster

    ecstatichamster Member

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    Strangely enough surgeons have more freedom than other doctors. Surgeries aren’t “evidence based” quite often and perhaps this is why so many unnecessary ones are done every year. In this case, Doug Lindsay was able to convince a surgeon to operate. Notice how careful he had to be lest word get out amongst the doctors and they close ranks and refuse to do the surgery.
     
  11. yerrag

    yerrag Member

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    Doug was determined and found a way to lift himself out of a hopeless situation. And he has good friends. He beat the odds. Very happy for him.

    I wonder what meds he now takes. What does not having an adrenal medulla make one deficient on? Adrenaline, DHEA, Progesterone?
     
  12. Kartoffel

    Kartoffel Member

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    That sort of attitude is not going to work, in my experience. Doctors don't see patients as equals, and I know from my conversations with medical students and young doctors that they feel nothing but contempt and annoyance when the have to deal with a patient that is "self diagnosing". Remember, they are the experts, they have studied long and hard to become a doctor, an authority, and so they won't respect you when you shoot facts and suggestions at them. They will either perceive you as a threat, a nuisance, or as an insult to their ego.
    If you want anything from them, like a certain test or drug, you have to choose your words carefully so that they can make it seem like it was their idea. A long time ago, I made the mistake of bringing a few study abstracts to my doctor at the time to convince him of the benefits of a certain drug. The look on his face was quite extraordinary as he could barely hide his contempt and ridicule. He asked me, if I had studied medicine, and when I said no, he told me that I was in no position to understand what those studies say. Needless to say, I didn't get the drug.
     
  13. opson123

    opson123 Member

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    Let me guess, instead of the drug you asked, he wanted you to try SSRIs?
     
  14. tankasnowgod

    tankasnowgod Member

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    When you say "not going to work," what do you mean? I said, basically, that doctors should be treated as an equal. And they are. They are just another human, they aren't God, and the words out of their mouth shouldn't be treated as gospel. I didn't make any reference to "self diagnosing," nor did I say to pretend to be superior, or be insulting.

    Clearly, in your second example, you didn't set yourself up to be an equal. Especially if you said "no" when he asked if you studied medicine. Why did you say no? Isn't studying medicine what we do on this forum? Why didn't you say something like "I've been an independent researcher of medicine (or metabolism) for X years now?"

    Of course, this isn't to say that there aren't doctors out there with an authority complex, because there are a lot. And you might have to go through a few different ones. But that is true of almost any industry. People are willing to shop around at multiple car dealerships before making a purchase, for example, and most people will own several cars in their lifetime, making cars easily replaceable. But, you only get one mind and body in this life, and they are irreplaceable, making them much more valuable than material things. Should we be putting less effort into people who deal with our health than looking for someone to sell us a car?
     
  15. Kartoffel

    Kartoffel Member

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    Well, you better not tell them that.

     
  16. Jem Oz

    Jem Oz Member

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    I admire this guy's persistence in not giving up on himself, but it's a shame he still had to go down the slice and dice path. I doubt just removing the medullas is the real fix to his problem, despite the improvements.
     
  17. Tenacity

    Tenacity Member

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    I suffer from similar issues to Doug and thought the same.

    Thanks @ecstatichamster for posting.
     
  18. burtlancast

    burtlancast Member

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    What this man did is what millions diagnosed with cancer attempt but are time-bound from their disease.

    He succeeded because he had the brains, the time and the friends.

    Which gives us the solution to the world's health problems: get the best scientists, afflict them with cancer, and you'll be amazed how fast they come with a cancer cure.
     
  19. Terma

    Terma Member

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    ^ Hahahahah

    This thread is beautiful.
     
  20. intotheether

    intotheether Member

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    Remarkable individual.
     
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