Any of you seen remission yourself or are aware of remission using unconventional means?
The reason I ask is because a loved one is facing cancer resurgence and we’re beginning to get a little desperate.
Context:
As the prevailing narrative within the conventional medicine realm seems to state androgens are "rocket fuel" for cancer (literally something I overhead said by a well-renowned Harley Street doctor).
However, based on the other prostate cancer threads on here, it seem that this hypothesis is extremely flawed.
For example, having read this:
Cancer "paradox": Testosterone Treats Prostate Cancer
And this:
Another Confirmation That Testosterone Can Treat Prostate Cancer
Both (ironically) seem to suggest androgens could in fact be PREVENTATIVE.
So, unless you tell me otherwise, I imagine they are pushing this androgen suppressing narrative because the drugs are extremely lucrative?
But with that said, in light of this new information, I would really appreciate it if you could please help me understand what or where may be a wise for us to look next in helping him overcome it?
If it's not androgen suppressants, then what?
Thank you.
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Vitamin D and Androgen.
1,25 D in the presence of endogenous testosterone inhibits prostatic growth, whereas 1,25 D in the absence of endogenous testosterone does not affect prostatic growth. The growth inhibitory activity of 1,25 D in the presence of testosterone may be mediated through the ligand activated AR and VDR pathways
Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
Median tissue levels of dihydrotestosterone were 91% lower in recurrent prostate cancer (1.25 pmol/g tissue) than AS-BP (13.70 pmol/g tissue; Wilcoxon two-sided, P < 0.0001). Six patients had undetectable levels of dihydrotestosterone and one of those patients also had an undetectable level of testosterone. Recurrent prostate cancer patient 14 suggests that prostate cancer can recur completely independent of testicular androgens. Both methods showed that median dihydrotestosterone levels decreased by ∼90% in recurrent prostate cancer
The reason I ask is because a loved one is facing cancer resurgence and we’re beginning to get a little desperate.
Context:
- Older man (in his early 70’s)
- Prostate removed 12 years ago
- Originally put on a course of Enzolutamide (Xtandi)
- Then, a course of zoladex (Goserelin)
- Now, he’s being suggested a new drug called Apalutamide (Erleada)
As the prevailing narrative within the conventional medicine realm seems to state androgens are "rocket fuel" for cancer (literally something I overhead said by a well-renowned Harley Street doctor).
However, based on the other prostate cancer threads on here, it seem that this hypothesis is extremely flawed.
For example, having read this:
Cancer "paradox": Testosterone Treats Prostate Cancer
And this:
Another Confirmation That Testosterone Can Treat Prostate Cancer
Both (ironically) seem to suggest androgens could in fact be PREVENTATIVE.
So, unless you tell me otherwise, I imagine they are pushing this androgen suppressing narrative because the drugs are extremely lucrative?
But with that said, in light of this new information, I would really appreciate it if you could please help me understand what or where may be a wise for us to look next in helping him overcome it?
If it's not androgen suppressants, then what?
Thank you.
-------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------------------------------------
Vitamin D and Androgen.
1,25 D in the presence of endogenous testosterone inhibits prostatic growth, whereas 1,25 D in the absence of endogenous testosterone does not affect prostatic growth. The growth inhibitory activity of 1,25 D in the presence of testosterone may be mediated through the ligand activated AR and VDR pathways
Androgen enhances the antiproliferative activity of vitamin D3 by suppressing 24-hydroxylase expression in LNCaP cells.
In this paper, we demonstrate that 25-hydroxyvitamin D3 at 500 nM significantly increases the expression of 24-hydroxylase mRNA and the increase is significantly decreased by 5alpha-dihydrotestosterone (DHT) at concentrations of 1-100 nM in androgen-sensitive prostate cancer cells LNCaP. 25-Hydroxyvitamin D3 at 500 nM and 1alpha,25-dihydroxyvitamin D3 at 10 nM inhibit LNCaP cell growth, and the growth inhibition is enhanced by 1 nM DHT. Neither 25-hydroxyvitamin D3 nor 1alpha,25-dihydroxyvitamin D3 at physiological concentrations has growth effect. However, in the presence of 1 nM DHT, both 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3 at physiological concentrations are clearly antiproliferative.Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
Median tissue levels of dihydrotestosterone were 91% lower in recurrent prostate cancer (1.25 pmol/g tissue) than AS-BP (13.70 pmol/g tissue; Wilcoxon two-sided, P < 0.0001). Six patients had undetectable levels of dihydrotestosterone and one of those patients also had an undetectable level of testosterone. Recurrent prostate cancer patient 14 suggests that prostate cancer can recur completely independent of testicular androgens. Both methods showed that median dihydrotestosterone levels decreased by ∼90% in recurrent prostate cancer