You should clarify. Are you saying that often the repair job doesn't finish or leaves scars (which I would subscribe to) , or that there is stress/destruction inherent in the regeneration process? The former is prescriptive of higher metabolism to complete the job.
EDIT: You answered this already. It sounds like we're on the same page.
Here's a timely Haidut post that speaks against the "wear and tear" theory:
Low, not high, metabolism creates oxidative stress
From the study: "Some electrons are directly transferred to O2 to generate reactive oxygen species (ROS) in the ETC. The second part of this review discusses the sites of ROS generation in each ETC complex, including sites IF and IQ in complex I, site IIF in complex II and site IIIQo in complex III, and the physiological and pathological regulation of ROS. As signaling molecules, ROS play an important role in cell proliferation, hypoxia adaptation and cell fate determination, but excessive ROS can cause irreversible cell damage and even cell death. The occurrence and development of a number of diseases are closely related to ROS overproduction"
Haidut's comments: "it is low oxidative metabolism (OXPHOS), not high, that causes ROS generation. In other words, it is low OXPHOS that causes aging, not high."
These are interesting correlations worth expanding upon. But the ROS angle is elegant because it explains a lot with a single vector.
Without nitpicking or sowing doubt on this point, can both positions be right, that low stress leads to longevity but also low ROS/high metabolism does as well?
agreed with your points about unfinished and scars.
I think that in a vacuum, there is no stress in regeneration. With all the stressors present, there might be.
regeneration of your dna through methylation increases cancer risk for example. Every attempt for that matter, to rejuvenate it, increases it
if this would also be the case without any carcinogenic stressors I don’t know. Are hunter and gatherers far from civilization getting cancer? Serious question
As soon as you are holding meat over fire, or smoking some leaves, you have carcinogenics present
Carcinogenics present = anabolism (necessary for regeneration) comes with increased cancer risk.
i even went as far as theorizing every „stressor“ this forum talks about as a direct or indirect carcinogenic
carcinogenics make catabolism through low metabolism necessary for survival
hypothyroidism is literally a naturally induced chemo therapy on your body. The low temps keep pufa in your tissue more stable, too
the cancer paradox is really weird, because people who look young for their age (before the chemo they are put on by their doc) seem to have higher risk. They are anabolic despite the carcinogenics. For them, there is certainly destruction in regeneration
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