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Seems like i have to start eating ginger again... i always drop it after few days for some reason. Also this study implies it increases atleast one serotonin receptor Identification of serotonin 5-HT1A receptor partial agonists in ginger - PubMedI like ginger I think it's effects are very broad tackles so many things: histamine, serotonin, AT1 receptor blocker, anti-glycation, it's my go to for many things:
Ginger--an herbal medicinal product with broad anti-inflammatory actions - PubMed
The anti-inflammatory properties of ginger have been known and valued for centuries. During the past 25 years, many laboratories have provided scientific support for the long-held belief that ginger contains constituents with antiinflammatory properties. The original discovery of ginger's...pubmed.ncbi.nlm.nih.gov
How would agonizing a serotonin receptor be a good thing, if serotonin is what we want to lower?Seems like i have to start eating ginger again... i always drop it after few days for some reason. Also this study implies it increases atleast one serotonin receptor Identification of serotonin 5-HT1A receptor partial agonists in ginger - PubMed
Don't know. I view things in their total benefits package. Ginger has too much going for it in terms of positives.How would agonizing a serotonin receptor be a good thing, if serotonin is what we want to lower?
I meant it as the only negative effect i have been able to found in studiesHow would agonizing a serotonin receptor be a good thing, if serotonin is what we want to lower?
Got ya. I am a ginger fan. Works beautiful for my digestion, and when I test out all these natural things that are supposed to be anti-inflammatory, like curcumin, boswellia, etc., ginger CO2 extract works better {for me} than any of them. In Peat world, estrogen, serotonin, PUFA, etc., etc. aren't desirable, but since nothing is perfect, sometimes you have to take a little bad with the good if you want therapeutic effects. Ginger has a good track record for being health promoting, and recent studies show it has strong anti-cancer properties.I meant it as the only negative effect i have been able to found in studies
That's pretty important.In addition to the comment above me, I would also add eugenol. It also inhibits COX, and is one of the few substances known to be such dual inhibitor and without much toxicity.
Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells - PubMed
Polymorphonuclear leukocytes (PMNL) play an important role in the modulation of inflammatory conditions in humans. PMNL cells recruited at the site of inflammation, release inflammatory mediators such as leukotrienes, proteolytic enzymes and reactive oxygen species. Among these, leukotrienes are...pubmed.ncbi.nlm.nih.govComputational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways - Scientific Reports
Chronic inflammation is triggered by numerous diseases such as osteoarthritis, Crohn's disease and cancer. The control of the pro-inflammatory process can prevent, mitigate and/or inhibit the evolution of these diseases. Therefore, anti-inflammatory drugs have been studied as possible compounds...www.nature.com
Since inhibition of lipoxygenase increases prostaglandins and the inhibition of cyclooxygenase increases leukotrienes, the only two options are to inhibit both simultaneously or to eliminate ω−6 fatty acids entirely; I would strongly suggest doing the latter, and that more I read about them the more I tend to avoid them.
This isnt necessarily a bad thing. 5ht1a is the autireceptor for serotonin and thus decreases serotonin output . I think it also increase dopamine.Seems like i have to start eating ginger again... i always drop it after few days for some reason. Also this study implies it increases atleast one serotonin receptor Identification of serotonin 5-HT1A receptor partial agonists in ginger - PubMed
?How would agonizing a serotonin receptor be a good thing, if serotonin is what we want to lower?