• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

PUFA metabolites may drive bacterial infections and their resistance to antibiotics

haidut

Member
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
The study below demonstrates yet again that there is hardly an aspect of human health that PUFA does not influence in a detrimental manner, even seemingly non-metabolic aspects such as bacterial infections. As it turns out, most bacteria express the enzyme family known as lipoxygenases (LOX) and uses those enzymes to evade the endogenous immune response. Namely, once inside the host the bacteria use their LOX enzymes to synthesize various PUFA metabolites known as lipoxins, which dampen the immune response and allow the bacteria to survive. In addition, apparently the activation of LOX is also involved in the bacteria exchanging genes associated with antibiotic resistance. As such, the authors suggest that targeting the LOX pathway with various inhibitors may be beneficial for both helping the host handle bacterial infections on its own (without antibiotics) and/or preventing antibiotic resistance in severe infections that mandate usage of antibiotics. LOX inhibitors or leukotriene (LOX metabolites) antagonists are already in clinical use and have recently been proposed as curative treatments for virtually every chronic disease driven by low-grade inflammation (i.e. all of them). Of course, the more systemic and beneficial approach would be to deplete PUFA in the organism altogether. The success of the latter approach has already been corroborated by multiple studies demonstrating that PUFA (EFA) deficient animals are remarkably resistant to both developing bacterial infections and dying from them, even when the bacterial/endotoxin injections administered doses hundreds of times higher than what is sufficient to kill animals not deficient in PUFA/EFA.

Bacterial and Protozoan Lipoxygenases Could be Involved in Cell-to-Cell Signaling and Immune Response Suppression
Microbial lipoxygenases: a next target against antibiotic resistance? | Laboratory News
"...One group of the identified bacterial clades does not fit the picture described above but shows quite different associations. It is as though these ‘evil-doers’ have learnt to use lipoxygenases not for constructive, but for destructive purposes — as virulence factors. This mechanism has been experimentally demonstrated for a nosocomial pathogen, Pseudomonas aeruginosa — its lipoxygenase initiates synthesis of lipoxins, which, as was mentioned above, dampen inflammation and thus facilitate invasion of the host tissues. Our study showed that numerous other opportunistic and nosocomial pathogens — i.e. Acinetobacter baumannii, Burkholderia cepacia, Enterobacter cloacae, Cedecea lapagei — could use lipoxygenase this way. Notably, lipoxygenases are transferred very rapidly in the particular subclades of pathogens — like antibiotic resistance genes. Pseudomonas aeruginosa, mentioned above, appeared to be one of such ‘superspreaders’. This provides a final link between our bioinformatic results and experimental works on this bacterium. Such ‘superspreading’ of possible virulence factors between dangerous antibiotic-resistant bacteria is an important warning sign. As yet, we do not know whether the presence of lipoxygenase is crucial for virulence in these pathogens, but we hope to attract the attention of our scientific and medical colleagues to this enzyme: maybe, it is the next target in fighting antibiotic resistance."
 
Similar threads
Thread starter Title Forum Replies Date
haidut PUFA (metabolites) Drive Heart Failure And Possibly Diabetes Scientific Studies 4
pedigree Are supplements that use PUFA oils as a carrier oil harmful? Health 1
Michael Mohn Billionaire$ hate this simple trick! What is the best low pufa olive oil? Fats 44
I Is vaseline or mineral oil pufa safe?? Ask For Help or Advice 4
C Pufa free kibble for dogs? Animals 9
A Homestead group seeking new members—focused on dairy, ruminant animals, tropical fruit, & no-seed/no-PUFA diet Society 7
sevenzy What happens to PUFA in Nixtamalized corn? Diet 1
haidut PUFA are remarkably estrogenic, toxic to the ovaries Scientific Studies 13
UG Krishnamurti More lipofuscin after being LOW PUFA for 2 years Skin 43
PeatandPotatoes What is the best way to deplete PUFA? Polyunsaturated Fats, Seed Oils 4
IROM Stock Watch: Unity Biotechnology, $UBX, due for clinical data release. Senescence and diabetic macular edema + PUFA-link Pharmaceutical Drugs 10
G Craving High PUFA Food Ask For Help or Advice 14
J High brix level, stays around 4.9. Could it be PUFA related? Blood Sugar 0
A.R Is PUFA more harmful or is Mercury/Heavy metals Metabolism 15
J The only pufa rich food I eat are eggs now Diet 19
haidut PUFA required for periodontal disease, aspirin may help Scientific Studies 12
haidut Protein and saturated fats beneficial, PUFA detrimental for thyroid Scientific Studies 5
Hans How to deplete yourself of PUFA quickly and safely Articles & Scientific Studies 11
P Farm-raised, soy-free pastured eggs have more PUFA and less SFA? Diet, Recipes 25
U Masa Harina and Pufa Diet, Recipes 15
J NW-1 eats pufa and keto diet Hair & Nails 33
A So you've just eaten out an unhealthy meal with PUFA - what supplements to help counteract? Ask For Help or Advice 24
Mauritio Serotonin, PUFA and histamine increase leaky brain Articles & Scientific Studies 6
pauljacob Which has more PUFA: Yolk or White? Diet 15
G Am I interpreting this correctly? PUFA Content in Food Ask For Help or Advice 3
M Chicken Neck — Thyroid and PUFA Thyroid and Hormones 17
haidut Maternal high-PUFA diet causes alcoholism, aggressiveness, early puberty, and hyper-estrogenism in offspring Scientific Studies 0
haidut Inflammation (from PUFA), not telomeres, determines lifespan / healthspan Scientific Studies 0
G How many grams of PUFA's does ur average gel have? D 2
D Aspirin can prevent the depletion of PUFA Aspirin 35
J Does anyone know a good quality Olive oil brand that is not laced with PUFA-UK accessible? Fats 8
Mauritio Why PUFA is bad: how high membrane polyunsaturation decreases longevity Scientific Studies 42
ecstatichamster Longevity v PUFA cell content Dr Peat is right Scientific Studies 2
GorillaHead Can Skin PUFA be displaced with topical saturated application? Skin 6
M Weston price pufa article Polyunsaturated Fats, Seed Oils 0
TypicalJock Hello, I used to suffer from thickness in blood, does consuming PUFA effect the thickness of blood Ask For Help or Advice 7
johnwester130 Mercola is now anti-PUFA Miscellaneous Health Discussions 14
N Uncoupling to deplete PUFA... Polyunsaturated Fats, Seed Oils 60
md_a PUFA thrombotic complications covid-19 Scientific Studies 0
Braveheart Masterjohn...Are PUFA'S Toxic? Polyunsaturated Fats, Seed Oils 24
Marine Sweet chesrnut and pufa? Good or bad? Diet, Recipes 19
D Link between depression/obesity and PUFA in this study? Polyunsaturated Fats, Seed Oils 0
haidut DHT / Progesterone / aspirin treat, cortisol ineffective, PUFA promotes prostate cancer Scientific Studies 3
H PUFA experiences Polyunsaturated Fats, Seed Oils 2
M Is Google pro-PUFA? Polyunsaturated Fats, Seed Oils 8
haidut PUFA promote torpor / hibernation, decrease lifespan Scientific Studies 10
haidut PUFA are potent immunosuppresive agents Scientific Studies 0
haidut Blocking PUFA/prostaglandins restores metabolism and reverses brain aging Scientific Studies 5
V Comparing PUFA in beans. Not so bad? Diet 9
Brandin vitamin e to balance eggs pufa. Polyunsaturated Fats, Seed Oils 15

Similar threads

Top