Aspirin Increases Plasma Levels Of Short Chain Fatty Acids (SCFA)

[haidut]

For people that cannot eat carrot or are willing to experiment with the reported beneficial effects of SCFA like butyrate and acetate, this study gives another option. A human dose of 2,500mg - 3,000mg aspirin daily dramatically increased levels of SCFA in rat blood. This should have the effect of mitigating some of the negative effects of free floating PUFA as well as provide systemic benefits for all tissues reachable by the circulation. Please note that the 800mg/L dose was the most effective. That is the dose that translates to the human dose listed above.

http://www.ncbi.nlm.nih.gov/pubmed/9669495

"...Analysis of variance and a post-hoc Fisher's protected least significant differences test revealed significantly increased levels (P < 0.05) of monocarboxylic acids, n-hexanoate, n-octanoate, n-decanoate, n-dodecanoate, and dicarboxylic acids, adipate (C6,) and suberate (C8): 78.7 +/- 36.2, 61.1 +/- 30.6, 215 +/- 151, 47.5 +/- 24.0, 3.64 +/- 2.09 and 1.71 +/- 1.45 micromol/l in the 800 mg/l aspirin group compared to 23.8 +/- 12.3, 20.1 +/- 9.0, 24.3 +/- 12.1, 6.3 +/- 5.6, 0.56 +/- 0.50 and 0.44 +/- 0.25 micromol/l in the control group, respectively. These levels were also increased in the 400 or 1200 mg/l aspirin groups but less so. These findings may help us to understand the aspirin toxicity in Reye's syndrome."

 

[RPDiciple]

around 700mg x4 a day. Thats np, will do or 1 gram at breakfast, 500,500 and 1gram before bed maybe even better :p

 

[Dean]

A thread I was following seemed to have the consensus view that aspirin and niacinamide are counterproductive if you are trying to improve liver function. So, which would be the higher priority--improving compromised/fatty liver or mitigating FFAs?

 

[RPDiciple]

small amount of niacinamide helps liver. 150mg a day

 

[haidut]

small amount of niacinamide helps liver. 150mg a day

I did some research myself and it seems that Peat is right again. Lower doses of aspirin and niacinamide inhibit lipolysis but do not affect the ability of the liver to get rid of excess fat through glucuronidation or beta oxidation. The dose of niacinamide is probably 50mg - 100mg taken 3 times a day. Aspirin dosage would be about the same.
Higher doses of these may indeed fatten the liver and in fact taking more than 3,000mg niacinamide a day is known to raise liver enzymes, especially ALT, which is common in liver fattening. Aspirin is more nebulous, since it is known to protect the liver from acetaminophen. But it may overburden the liver with all the unmetabolized fat heading back to the liver considering aspirin inhibits fatty acid synthase, lipid storage, and lipolisys.
The HIV study using aspirin was (conveniently) stopped using as a reason the small and transient increase in liver enzymes that 4g of aspirin daily induced in the patients. Btw, many/most HIV patients have liver damage as is and the issue could have been unrelated to aspirin at all. It's just something to keep in mind if taking large doses of the 2 substances and liver tests come back elevated.

 

[nullredvector]

I did some research myself and it seems that Peat is right again. Lower doses of aspirin and niacinamide inhibit lipolysis but do not affect the ability of the liver to get rid of excess fat through glucuronidation or beta oxidation. The dose of niacinamide is probably 50mg - 100mg taken 3 times a day. Aspirin dosage would be about the same.
Higher doses of these may indeed fatten the liver and in fact taking more than 3,000mg niacinamide a day is known to raise liver enzymes, especially ALT, which is common in liver fattening. Aspirin is more nebulous, since it is known to protect the liver from acetaminophen. But it may overburden the liver with all the unmetabolized fat heading back to the liver considering aspirin inhibits fatty acid synthase, lipid storage, and lipolisys.
The HIV study using aspirin was (conveniently) stopped using as a reason the small and transient increase in liver enzymes that 4g of aspirin daily induced in the patients. Btw, many/most HIV patients have liver damage as is and the issue could have been unrelated to aspirin at all. It's just something to keep in mind if taking large doses of the 2 substances and liver tests come back elevated.

Any updates to any of this @haidut ?
Are there any substances to speed up glucuronidation?

 

[ecstatichamster]

How do you translate animal study dosages to humans? This is intriguing.

 

[haidut]

Any updates to any of this @haidut ?
Are there any substances to speed up glucuronidation?

Taurine and glycine both speed up glucuronidation. This is one of the reasons for RedBull to contain taurine.

 

[bluewren]

Great info.
Thanks haidut.

 

[Momado965]

I did some research myself and it seems that Peat is right again. Lower doses of aspirin and niacinamide inhibit lipolysis but do not affect the ability of the liver to get rid of excess fat through glucuronidation or beta oxidation. The dose of niacinamide is probably 50mg - 100mg taken 3 times a day. Aspirin dosage would be about the same.
Higher doses of these may indeed fatten the liver and in fact taking more than 3,000mg niacinamide a day is known to raise liver enzymes, especially ALT, which is common in liver fattening. Aspirin is more nebulous, since it is known to protect the liver from acetaminophen. But it may overburden the liver with all the unmetabolized fat heading back to the liver considering aspirin inhibits fatty acid synthase, lipid storage, and lipolisys.
The HIV study using aspirin was (conveniently) stopped using as a reason the small and transient increase in liver enzymes that 4g of aspirin daily induced in the patients. Btw, many/most HIV patients have liver damage as is and the issue could have been unrelated to aspirin at all. It's just something to keep in mind if taking large doses of the 2 substances and liver tests come back elevated.

Do you think people who gained fat using b3 or aspirin was because lypolysis inhibition or glucuronidation or beta oxidation inhibition?

 

[haidut]

Do you think people who gained fat using b3 or aspirin was because lypolysis inhibition or glucuronidation or beta oxidation inhibition?

This comment is from more than 3 years ago. Aspirin and niacinamide inhibit excessive lipolysis but not baseline. If somebody gains weight on aspirin it is probably due to low thyroid function and/or eating too much fat. Aspirin and niacinamide are not known to cause obesity.

 

[Momado965]

This comment is from more than 3 years ago. Aspirin and niacinamide inhibit excessive lipolysis but not baseline. If somebody gains weight on aspirin it is probably due to low thyroid function and/or eating too much fat. Aspirin and niacinamide are not known to cause obesity.

Sweet!