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Ammonia May Be The Direct Cause Of Ulcers In The Stomach

haidut

Member
Joined
Mar 18, 2013
Messages
18,824
Location
USA / Europe
The official cause of stomach ulcers is of course still H. pylori infection but up until now the exact mechanism through which the bacteria damages the mucosa was not known. It seems that the bacteria is really good at breaking down urea into ammonia and CO2 and it is the ammonia which does the damage. So, maybe a possible treatment of ulcers (other than antibiotics to kill the bacteria) would be a hefty dose of urea or another chemical that would lower the pH in the stomach.
I wonder if lowering/chelating ammonia with things like ceylon cinnamon would also have a protective effect...

Helicobacter pylori moves through mucus by reducing mucin viscoelasticity
Physicists Uncover Swimming Secrets of H. pylori Bacteria | Research
"...Not so in stomach mucus. There, H. pylorisecretes an enzyme called urease, which breaks down urea in the stomach into carbon dioxide and ammonia, giving the smell of ammonia to the breath of infected people. Ammonia, a base, reacts with the stomach mucus, raising its pH and liquefying it. “It de-gelled the gel, and this reversible gelation was the key to letting this bacterium get across,” says Bansil, who published this research in Proceedings of the National Academies of Sciences in 2009."
 

Lewistx

Member
Joined
Aug 15, 2019
Messages
56
Hey I just completed yet another 2 weeks course of antibiotics they took biopsy and my digest is still sickly how can I go about resolving this with other chemicals
The official cause of stomach ulcers is of course still H. pylori infection but up until now the exact mechanism through which the bacteria damages the mucosa was not known. It seems that the bacteria is really good at breaking down urea into ammonia and CO2 and it is the ammonia which does the damage. So, maybe a possible treatment of ulcers (other than antibiotics to kill the bacteria) would be a hefty dose of urea or another chemical that would lower the pH in the stomach.
I wonder if lowering/chelating ammonia with things like ceylon cinnamon would also have a protective effect...

Helicobacter pylori moves through mucus by reducing mucin viscoelasticity
Physicists Uncover Swimming Secrets of H. pylori Bacteria | Research
"...Not so in stomach mucus. There, H. pylorisecretes an enzyme called urease, which breaks down urea in the stomach into carbon dioxide and ammonia, giving the smell of ammonia to the breath of infected people. Ammonia, a base, reacts with the stomach mucus, raising its pH and liquefying it. “It de-gelled the gel, and this reversible gelation was the key to letting this bacterium get across,” says Bansil, who published this research in Proceedings of the National Academies of Sciences in 2009."
 

Don Quixote

Member
Joined
Apr 26, 2020
Messages
196
Why could urea be useful? Wouldn't that be more substrate for ammonia formation?
I have the same question. Urea is neutral ph so would not lower the ph . I have a supplement called renamide that has urea in it and I got a bad ulcer after it, but don't know if it is related .
 

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