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While searching for the ideal calcium supplement I came across calcium alpha-ketoglutarate which I think has not been discussed on this forum yet and looks highly interesting. There is a study showing that calcium alpha-ketoglutarate extends lifespan and compresses morbidity in aging mice...
Peat mentioned this in a few of his articles and the process of formation of basic amino acids from simpler chemicals is well-known. But up until now the "trigger" or "spark" of this process was not known. The study below shows that low-energy electrons from cosmic radiation can serve as that...
I posted a number of studies on Ceylon cinnamon and its metabolite sodium benzoate, showing their benefit in Parkinson disease, depression and anxiety. While all of those studies were on animal models, the toxicity of ammonia in the brain is undisputed and its role in all of these disease has...
The official cause of stomach ulcers is of course still H. pylori infection but up until now the exact mechanism through which the bacteria damages the mucosa was not known. It seems that the bacteria is really good at breaking down urea into ammonia and CO2 and it is the ammonia which does the...
Hyperammonemia can provoke irreversible damage to the developing brain, with the formation of cortical atrophy, ventricular enlargement, demyelination or gray and white matter hypodensities. Among the various pathogenic mechanisms involved, alterations in cerebral energy have been demonstrated...
Medium-chain triglyceride supplementation under a low-carbohydrate formula is a promising therapy for adult-onset type II citrullinemia
Results
One of the patients displaying hyperammonemic encephalopathy completely recovered with all normal laboratory findings. Others notably improved in...
Metabolism of galactose in the brain and liver of rats and its conversion into glutamate and other amino acids. - PubMed - NCBI
Abstract
Time- and dose-dependent measurements of metabolites of galactose (with glucose as control) in various organs of rats are discussed. Not only the liver but...
Rat study, but should be applicable to humans as well. Human equivalent dosage is about 20mg of biotin per day, which may seem very high to some. However, it has been shown to be safe in humans for up to a year administration and incidentally this is the dose used in humans to lower cholesterol...
Several human studies and some animals ones. Keep in mind that most of the human patients had severe liver disease and as such their ammonia levels were quite high (some people were in coma). As such, the high doses of zinc used in those studies (150mg-200mg elemental zinc per day) are probably...
The study was with humans and also included exercise, which makes thiamine even more interesting to athletes. The type of thiamine used was TTFD, which is the scientific name for allithiamine, and the dose was 10mg/kg. That would mean a total daily dose in the range of 600mg-900mg for most...