ecstatichamster
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D2 is stimulated by digestive bile salts
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation : Abstract : Nature
In both rodents and humans, the most thermogenically important tissues are specifically targeted by this mechanism because they coexpress D2 and TGR5. The BA–TGR5–cAMP–D2 signalling pathway is therefore a crucial mechanism for fine-tuning energy homeostasis that can be targeted to improve metabolic control.
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation : Abstract : Nature
In both rodents and humans, the most thermogenically important tissues are specifically targeted by this mechanism because they coexpress D2 and TGR5. The BA–TGR5–cAMP–D2 signalling pathway is therefore a crucial mechanism for fine-tuning energy homeostasis that can be targeted to improve metabolic control.