Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

[Hugh Johnson]

Abstract​

Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation can lead to immune exhaustion and non-responsiveness, we sought to determine the effects of pre-exposure to the mRNA-LNP on adaptive immune responses and innate immune fitness. We found that pre-exposure to mRNA-LNPs or LNP alone led to long-term inhibition of the adaptive immune response, which could be overcome using standard adjuvants. On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while resistance to Candida albicans decreased. The diminished resistance to Candida albicans correlated with a general decrease in blood neutrophil percentages. Interestingly, mice pre-exposed to the mRNA-LNP platform can pass down the acquired immune traits to their offspring, providing better protection against influenza. In summary, the mRNA-LNP vaccine platform induces long-term unexpected immunological changes affecting both adaptive immune responses and heterologous protection against infections. Thus, our studies highlight the need for more research to determine this platform's true impact on human health.

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion - PubMed

Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component...

pubmed.ncbi.nlm.nih.gov

Fun.

 

[Fred]

Another fun thing to think about ...
Seeing as how there are a few sextillion molecules in each injection... that would mean that if an injection was "contaminated" with 1 ppm of the appropriate material, you could still assemble roughly a million nano-machines each having a million parts inside of every injected person, using a "contamination-level" amount of material. Fauci mentioned "self-assembling nanoparticle vaccines" back in 2019.

 

[babz]

What is meant by pre-exposure? In language it seems to mean before exposure. But I don’t know why they used that language.

 

[Hugh Johnson]

What is meant by pre-exposure? In language it seems to mean before exposure. But I don’t know why they used that language.

Basically this. It means not at the same time, but first mRNA, then later the infectious agent. The langue saves them time and words since it is understood by the intented audience. And it makes it less accessible to lay public.