Glycine - Prototombin Time?

[yomama]

Hello, I know Glycine has antiplatelet (aggregation) properties, for example here:
http://link.springer.com/article/10.100 ... 012-1422-8
which is supposed to increase clotting time.

Now on a Milk thistle thread on this forum:
http://raypeatforum.com/forum/viewtopic.php?t=5942
there is a reference to a study:
http://www.ncbi.nlm.nih.gov/pubmed/20233000
where they see that Glycine reduces the prothrombin time.

I looked on Google but I only found a few references, like this:
http://www.cabdirect.org/abstracts/19501405260.html
and this:
http://www.nature.com/icb/journal/v43/n ... 9654a.html
so my question is do you know more about that (Glycine, platelet agregation and prothrombin time) ?

Thanks

 

[OrangeJuice]

Interesting...

I had two consecutive days where I woke up in bed a little earlier than normal because I felt the feeling of blood drops running down my nostril onto my top lip, which turned out to be a bloody noise and i had to rush to the sink and get some kleenex to stop it.

I was trying to figure out what changed in my diet or if there was anything different in the environment (dry air) that may have caused this all of a sudden.

Looking back the only thing i really added to my diet (COINCIDENTALLY) was I had a little Glycine in my coffee the past few days during the day to counter the big muscle meat lunches I was having. I haven't used my Glycine supplement before this for a few weeks, so I am wondering if that's the cause.

Not sure if that's the cause...i've had issues with bloody noses in the past during the night and always the same nostril, usually during the winter months/dry air. They are random and havnen't really had the problem recently, but when i used to have them i was supplementing Zinc occasionally for acne.

 

[haidut]

post 100316 Hello, I know Glycine has antiplatelet (aggregation) properties, for example here:
http://link.springer.com/article/10.100 ... 012-1422-8
which is supposed to increase clotting time.

Now on a Milk thistle thread on this forum:
http://raypeatforum.com/forum/viewtopic.php?t=5942
there is a reference to a study:
http://www.ncbi.nlm.nih.gov/pubmed/20233000
where they see that Glycine reduces the prothrombin time.

I looked on Google but I only found a few references, like this:
http://www.cabdirect.org/abstracts/19501405260.html
and this:
http://www.nature.com/icb/journal/v43/n ... 9654a.html
so my question is do you know more about that (Glycine, platelet agregation and prothrombin time) ?

Thanks

Anything that opposes estrogen and/or serotonin will thin the blood. Caffeine, aspirin, progesterone, magnesium, etc all do that and glycine is also in the list of such substances.

 

[yomama]

post 100328 Anything that opposes estrogen and/or serotonin will thin the blood. Caffeine, aspirin, progesterone, magnesium, etc all do that and glycine is also in the list of such substances.

that is my question, a blood thinner is supposed to increase prothrombin time but these studies show it reduces it as if it were a pro-coagulants

 

[Parsifal]

Does bleading occur because of the blood thinning or because of blood vessels leakage (too much NO)?

Gelatin is high in arginine so might explain that?

 

[haidut]

post 100330

post 100328 Anything that opposes estrogen and/or serotonin will thin the blood. Caffeine, aspirin, progesterone, magnesium, etc all do that and glycine is also in the list of such substances.

that is my question, a blood thinner is supposed to increase prothrombin time but these studies show it reduces it as if it were a pro-coagulants

Well, I don't know what to tell you. I found studies saying the exact opposite - glycine thins the blood. But since glycine and gelatin are given to stop intestinal bleeding your findings may be valid. Without seeing the full studies I can't tell if glycine was pro-coagulatory or the increase in pro=thrombin time was a secondary effect.

 

[yomama]

post 100321Looking back the only thing i really added to my diet (COINCIDENTALLY) was I had a little Glycine in my coffee the past few days during the day to counter the big muscle meat lunches I was having. I haven't used my Glycine supplement before this for a few weeks, so I am wondering if that's the cause.

How much was the platelet count in your last blood test?

 

[yomama]

post 100339 Does bleading occur because of the blood thinning or because of blood vessels leakage (too much NO)?

"thinned" blood is not a cause of bleeding per-se, it could make it an issue once you start (bleeding), I mean coagulation factors are different from factors which make you bleeding as mechanical/pressure issues, vessels leakage etc., collagen metabolism is involved in the vessels health

 

[OrangeJuice]

post 100417

post 100321Looking back the only thing i really added to my diet (COINCIDENTALLY) was I had a little Glycine in my coffee the past few days during the day to counter the big muscle meat lunches I was having. I haven't used my Glycine supplement before this for a few weeks, so I am wondering if that's the cause.

How much was the platelet count in your last blood test?

I don't know....i haven't had a blood test in YEARS.