Fighting Prostate Cancer for 12 years - Drugs Waning - CT Scan Shows Spread to Ribs/Pelvis - What to do next?

[S.Seneff]

View: https://youtu.be/Gs7LUWlkCno?t=803

 

[tom94]

Very much yes. You describe a common dilemma with people that are suffering from both a serious illness and are on therapy that is not helpful or harmful at the same time. If these people are then additionally unknownleadgeable in physiology or extremely trusting in their malpracticing doctors it’s nearly impossible to change their approach.

And yes, then one has tp decide if it does more harm than good to sow doubts about their therapy regime - even if it is harmful.

I still think getting the prolactin-antagonism into the mix is promising. On various levels.

First: it might be able to offset some of the harmful effects of the anti-androgen regimen even if continued. Deranged prolactin signaling and effects are in fact downstream from distorted androgen homoeostasis and signals reciprocally.
It could in the very least alleviate the burden of thf harmful anti-androgen therapy while at the same time effect independent pathonechanisms positively.

Second: it has actual publications to substantiate it. Both individual case reports and broader publications. This is helpful to get an actual doctor to prescribe the anti-prolactin medication. This is not thr case with say chlorine-stuff that was also recommended in this thread.

Note also that the PC cured by prolactin antagonism is named „androgen independent pc“ - which is exactly the stuff you deal with. Just named wrongly by stupid researchers. They mean: if anti-androgen Therapy isn’t working the PC is androgen Independent. That’s wrong on many levels but in practice at least this concept is helpful: if the therapist is convinced that he is dealing with an androgen indipendent stage of Prostate cancer then the therapist can both end anti-androgen therapy or / and at least seek other means, which in this case, backed by literature is anti-prolactin thearapy. Also the medication for it is cheap and widely available - at least cabergolin and the like

Thanks @LeeLemonoil

Appreciate all your insights. Really have been helpful.

My challenge now is how best to articulate them to the person in question which is going to be incredibly tough.

If you or anyone else reading this know of any holistic orientated practitioners who would be willing to chat to him and explain the logic and rationale behind why androgren suppressants are flawed and why these alternative methods have a more robust, credibly basis then please message me privately.

The only way this will pack a punch is if it's delivered from someone with a medical/scientific background.

 

[tom94]

For reference

Testosterone Therapy May Be The Answer To Prostate Cancer

Dr. Peat has speculated about this, and Haidut has also. This is a review study on "supra physiological" dosages of testosterone to treat prostate cancer. Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions Abstract : "Since Huggins...

raypeatforum.com

Awesome - cheers boss. This looks extremely insightful!

 

[tom94]

"COMBAT, a small, phase 2 study supported by PCF, co-led by Hopkins investigators Mark Markowski, M.D., Ph.D., and Emmanuel Antonarakis, M.D., (now Director of Genitourinary Oncology at the University of Minnesota) tested the combination of BAT and immunotherapy in 45 men with metastatic castration-resistant prostate cancer (mCRPC). The men were treated with BAT in combination with nivolumab (an immunotherapy agent). “We saw an impressive clinical response rate of 40 percent,” says Markowski. “We also observed a durable benefit, lasting over a year, in a few patients who had received extensive prior therapies.” The results suggested that BAT alone has significant efficacy, while nivolumab improves responses in some patients. The combination of BAT with nivolumab was safe and well tolerated by the participants. Markowski and Antonarakis are designing a randomized Phase 3 study to compare combined BAT plus nivolumab versus standard treatments for patients with mCRPC."

Bipolar Androgen Therapy and the Immune System

Some men are exceptional responders to Bipolar Androgen Therapy (BAT). Its pioneer, medical oncologist Samuel Denmeade, M.D., Co-Director of the Johns Hopkins Prostate Cancer Program, has a few patients who have remained on BAT alone for several years. But for many men, the response is...

www.pcf.org

Fascinating - thanks for sharing @S.Seneff