Effects Of Vitamin D Supplementation In Older Adults With Alzheimer's Disease: A Randomised, Double-

Discussion in 'D' started by Mito, Oct 25, 2019.

  1. Mito

    Mito Member

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    Abstract
    OBJECTIVE:
    Our study aimed to assess the effect of a 12-month vitamin D supplementation on cognitive function and amyloid beta (Aβ)-related biomarkers in subjects with Alzheimer's disease (AD).

    METHODS : This was a randomised, double-blind, placebo-controlled trial. 210 AD patients were randomly divided into intervention and control groups. Participants received 12-month 800 IU/day of vitamin D or starch granules as placebo. Tests of cognitive performance and Aβ-related biomarkers were measured at baseline, 6 months and 12 months.

    RESULTS : Repeated-measures analysis of variance showed significant improvements in plasma Aβ42, APP, BACE1, APPmRNA, BACE1mRNA (p<0.001) levels and information, arithmetic, digit span, vocabulary, block design and picture arrange scores (p<0.05) in the intervention group over the control group. According to mixed-model analysis, vitamin D group had significant increase in full scale IQ during follow-up period (p<0.001).

    CONCLUSIONS:
    Daily oral vitamin D supplementation (800 IU/day) for 12 months may improve cognitive function and decrease Aβ-related biomarkers in elderly patients with AD. Larger scale longer term randomised trials of vitamin D are needed.

    Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomised, ... - PubMed - NCBI
     
  2. burtlancast

    burtlancast Member

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  3. Mauritio

    Mauritio Member

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    Very low dose huh ... interesting. Thank you.
     
  4. sunraiser

    sunraiser Member

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    Interesting stuff! I'd be interested in the trends in morbidity in a longer term study, too.

    I actually don't think 800iu truly is a low dose - I just think supplement companies use studies in very arbitrary short time frames to make it seem like a higher dose is needed for physiological change.
     
  5. Tristan Loscha

    Tristan Loscha Member

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    3000-6000 IU without additional Sunexposure and no overweight for a moderately active male is realistic.
     
  6. Tristan Loscha

    Tristan Loscha Member

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    The low-Dose is the phony official Dose,there was an actual crisis when the authors discovered they made an
    comma-error,and they doubled-down on it.
     
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